Gene Page: ZAP70

Summary
GeneID  7535
Symbol  ZAP70
Synonyms  FLJ17670|FLJ17679|SRK|STD|TZK|ZAP-70
Description  zeta-chain (TCR) associated protein kinase 70kDa
See related  HGNC:12858|MIM:176947|Ensembl:ENSG00000115085|HPRD:01495|
Locus tag  -
Gene type  protein-coding
Map location  2q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0004 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0001784phosphotyrosine bindingIEA-
GO:0005515protein bindingIPI7528772 |11891219 |12359715 
|12646565 
GO:0005524ATP bindingNAS1423621 
GO:0004715non-membrane spanning protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007243protein kinase cascadeNAS1423621 
GO:0006955immune responseIDA1423621 
GO:0018108peptidyl-tyrosine phosphorylationIEA-
GO:0050852T cell receptor signaling pathwayIEA-
GO:0043366beta selectionIEA-
GO:0050850positive regulation of calcium-mediated signalingIEA-
GO:0045060negative thymic T cell selectionIEA-
GO:0045059positive thymic T cell selectionIDA7630421 
GO:0046638positive regulation of alpha-beta T cell differentiationIEA-
GO:0046641positive regulation of alpha-beta T cell proliferationIEA-
GO:0046777protein amino acid autophosphorylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexIDASynap (GO term level: 8)8176201 
GO:0005829cytosolEXP11048639 |17652306 
GO:0005829cytosolIEA-
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmTAS12359715 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID7760813 
ACP1HAAP | MGC111030 | MGC3499acid phosphatase 1, soluble-HPRD,BioGRID11976341 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequenceAffinity Capture-Western
Co-crystal Structure		BioGRID8798643 |10078535 
CBLBDKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56Cas-Br-M (murine) ecotropic retroviral transforming sequence b-HPRD,BioGRID10074432 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD8366117 
CD3EFLJ18683 | T3E | TCRECD3e molecule, epsilon (CD3-TCR complex)Reconstituted ComplexBioGRID7761456 
-HPRD11855827 
CD5LEU1 | T1CD5 molecule-HPRD,BioGRID9378960 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)-HPRD,BioGRID10419455 
ZAP-70 interacts with Crk-I.BIND10419455 
ZAP-70 interacts with Crk-II.BIND10419455 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-likeZAP-70 interacts with CrkL. This interaction was modeled on a demonstrated interaction between human ZAP-70 and CrkL from an unspecified species.BIND10419455 
DBNLABP1 | HIP-55 | SH3P7drebrin-like-HPRD,BioGRID14557276 
FCGR3ACD16 | CD16A | FCG3 | FCGR3 | FCGRIII | FCR-10 | FCRIII | FCRIIIA | IGFR3Fc fragment of IgG, low affinity IIIa, receptor (CD16a)-HPRD7819147 
FCRL3FCRH3 | IFGP3 | IRTA3 | SPAP2Fc receptor-like 3Reconstituted ComplexBioGRID12051764 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID7760813 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD,BioGRID11572860 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-WesternBioGRID7629168 
LATLAT1 | pp36linker for activation of T cellsBiochemical ActivityBioGRID11368773 |12186560 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID10318843 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)Biochemical ActivityBioGRID9047237 
NFAM1CNAIP | FLJ40652 | bK126B4.4NFAT activating protein with ITAM motif 1-HPRD15143214 
PAG1CBP | FLJ37858 | MGC138364 | PAGphosphoprotein associated with glycosphingolipid microdomains 1-HPRD,BioGRID10790433 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID7629168 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD10867021 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID8638162 |10458769 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD,BioGRID7737297 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD,BioGRID7760813 
SH3BP23BP2 | CRBM | CRPM | FLJ42079 | RES4-23SH3-domain binding protein 2-HPRD11390470 
Affinity Capture-Western
Reconstituted Complex		BioGRID9846481 
SHBRP11-3J10.8 | bA3J10.2Src homology 2 domain containing adaptor protein B-HPRD,BioGRID12084069 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID8761298 |9685404 
SIT1MGC125908 | MGC125909 | MGC125910 | RP11-331F9.5 | SITsignaling threshold regulating transmembrane adaptor 1-HPRD,BioGRID10209036 
SLASLA1 | SLAPSrc-like-adaptor-HPRD,BioGRID10449770 
SLA2C20orf156 | FLJ21992 | MGC49845 | SLAP-2 | SLAP2Src-like-adaptor 2-HPRD,BioGRID11891219 
SLAMF6KALI | KALIb | Ly108 | MGC104953 | NTB-A | NTBA | SF2000SLAM family member 6-HPRD8756661 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD7629168 
TUBA4AFLJ30169 | H2-ALPHA | TUBA1tubulin, alpha 4a-HPRD8530437 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID7798261 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDaZAP70 autophosphorylates.BIND15735648 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_PRIMARY_IMMUNODEFICIENCY 3528All SZGR genes in this pathway
BIOCARTA_CSK_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_TCRA_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
PID_PI3KCI_PATHWAY 4940All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE 1414All SZGR genes in this pathway
REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 2725All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_DN 12984All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_1 4527All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_4 6134All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70 6733All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
RAMALHO_STEMNESS_DN 7455All SZGR genes in this pathway
VARELA_ZMPSTE24_TARGETS_DN 3818All SZGR genes in this pathway
MCCLUNG_COCAIN_REWARD_4WK 7547All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_STIMULATED_UP 2919All SZGR genes in this pathway
MARSON_FOXP3_CORE_DIRECT_TARGETS 1914All SZGR genes in this pathway
FINETTI_BREAST_CANCER_KINOME_GREEN 1614All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
CUI_GLUCOSE_DEPRIVATION 6044All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_DN 5438All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway


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