Summary ?
GeneID7554
SymbolZNF8
SynonymsHF.18|Zfp128
Descriptionzinc finger protein 8
ReferenceMIM:194532|HGNC:HGNC:13154|HPRD:01919|
Gene typeprotein-coding
Map location19q13.43
Pascal p-value0.098
Fetal beta1.175
DMG2 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg276496531958789751ZNF8-0.0360.36DMG:Nishioka_2013
cg150323931958789915ZNF83.63E-9-0.0132.34E-6DMG:Jaffe_2016
cg235484871958790298ZNF84.91E-8-0.0081.31E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZNF2640.900.88
CRKRS0.900.90
ZNF2240.890.90
AP1GBP10.890.91
MSL20.890.89
NSD10.890.88
CUGBP10.890.89
DDX60.890.90
PWWP2A0.890.90
CNOT10.880.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.72-0.81
MT-CO2-0.71-0.80
AF347015.27-0.69-0.78
IFI27-0.68-0.78
AF347015.8-0.68-0.79
MT-CYB-0.68-0.77
HIGD1B-0.68-0.77
AF347015.21-0.67-0.83
AF347015.33-0.66-0.74
AF347015.15-0.65-0.75

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160101All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162122All SZGR 2.0 genes in this pathway