Gene Page: MPPED1
Summary ?
| GeneID | 758 |
| Symbol | MPPED1 |
| Synonyms | 239AB|C22orf1|FAM1A |
| Description | metallophosphoesterase domain containing 1 |
| Reference | MIM:602112|HGNC:HGNC:1306|Ensembl:ENSG00000186732|HPRD:03663|Vega:OTTHUMG00000150566 |
| Gene type | protein-coding |
| Map location | 22q13.31 |
| Pascal p-value | 0.038 |
| Sherlock p-value | 0.95 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17426042 | chr1 | 48407274 | MPPED1 | 758 | 0.19 | trans | ||
| rs6813178 | chr4 | 71575238 | MPPED1 | 758 | 0.02 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CA11 | 0.83 | 0.85 |
| TNFRSF14 | 0.82 | 0.85 |
| EGFL7 | 0.81 | 0.76 |
| RHBDL1 | 0.81 | 0.79 |
| PRSS3 | 0.80 | 0.84 |
| SHISA4 | 0.78 | 0.79 |
| CCK | 0.76 | 0.74 |
| LTK | 0.76 | 0.75 |
| ASPDH | 0.76 | 0.76 |
| PNKD | 0.76 | 0.75 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KIAA1949 | -0.73 | -0.78 |
| NKIRAS2 | -0.72 | -0.73 |
| TUBB2B | -0.72 | -0.80 |
| ZNF45 | -0.72 | -0.74 |
| TTC27 | -0.72 | -0.75 |
| SETDB1 | -0.72 | -0.74 |
| CCDC123 | -0.71 | -0.75 |
| PKN1 | -0.71 | -0.77 |
| PPM1G | -0.71 | -0.74 |
| DOCK7 | -0.71 | -0.77 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PENG LEUCINE DEPRIVATION UP | 142 | 93 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| MASSARWEH TAMOXIFEN RESISTANCE UP | 578 | 341 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS POLYSOMY7 UP | 79 | 50 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS WITH HCP H3K27ME3 | 102 | 76 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES HCP WITH H3K27ME3 | 41 | 30 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K27ME3 | 341 | 243 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |