Gene Page: CA5A
Summary ?
GeneID | 763 |
Symbol | CA5A |
Synonyms | CA5|CA5AD|CAV|CAVA|GS1-21A4.1 |
Description | carbonic anhydrase VA, mitochondrial |
Reference | MIM:114761|HGNC:HGNC:1377|HPRD:00262| |
Gene type | protein-coding |
Map location | 16q24.3 |
Pascal p-value | 0.095 |
Fetal beta | -0.276 |
DMG | 1 (# studies) |
eGene | Caudate basal ganglia Putamen basal ganglia |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg02472906 | 16 | 87938341 | CA5A | 4.66E-4 | 0.198 | 0.046 | DMG:Wockner_2014 |
cg07544223 | 16 | 87965360 | CA5A | 5.88E-4 | -0.592 | 0.05 | DMG:Wockner_2014 |
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs13380772 | 16 | 87906337 | CA5A | ENSG00000174990.3 | 6.364E-7 | 0.01 | 63798 | gtex_brain_putamen_basal |
rs35367472 | 16 | 87913607 | CA5A | ENSG00000174990.3 | 2.535E-7 | 0.01 | 56528 | gtex_brain_putamen_basal |
rs59361827 | 16 | 87916688 | CA5A | ENSG00000174990.3 | 2.619E-7 | 0.01 | 53447 | gtex_brain_putamen_basal |
rs7498257 | 16 | 87919461 | CA5A | ENSG00000174990.3 | 2.819E-7 | 0.01 | 50674 | gtex_brain_putamen_basal |
rs4843275 | 16 | 87920548 | CA5A | ENSG00000174990.3 | 1.812E-7 | 0.01 | 49587 | gtex_brain_putamen_basal |
rs4843728 | 16 | 87921399 | CA5A | ENSG00000174990.3 | 2.792E-7 | 0.01 | 48736 | gtex_brain_putamen_basal |
rs61607056 | 16 | 87921607 | CA5A | ENSG00000174990.3 | 2.789E-7 | 0.01 | 48528 | gtex_brain_putamen_basal |
rs7203884 | 16 | 87923358 | CA5A | ENSG00000174990.3 | 4.676E-7 | 0.01 | 46777 | gtex_brain_putamen_basal |
rs11859896 | 16 | 87925260 | CA5A | ENSG00000174990.3 | 8.264E-7 | 0.01 | 44875 | gtex_brain_putamen_basal |
rs56768079 | 16 | 87930258 | CA5A | ENSG00000174990.3 | 3.375E-7 | 0.01 | 39877 | gtex_brain_putamen_basal |
rs55883615 | 16 | 87931142 | CA5A | ENSG00000174990.3 | 2.923E-7 | 0.01 | 38993 | gtex_brain_putamen_basal |
rs8058389 | 16 | 87931281 | CA5A | ENSG00000174990.3 | 5.841E-7 | 0.01 | 38854 | gtex_brain_putamen_basal |
rs397737528 | 16 | 87936356 | CA5A | ENSG00000174990.3 | 4.181E-7 | 0.01 | 33779 | gtex_brain_putamen_basal |
rs4843732 | 16 | 87939470 | CA5A | ENSG00000174990.3 | 2.967E-8 | 0.01 | 30665 | gtex_brain_putamen_basal |
rs8048719 | 16 | 87942424 | CA5A | ENSG00000174990.3 | 7.858E-8 | 0.01 | 27711 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
INPP4B | 0.67 | 0.68 |
DDAH1 | 0.66 | 0.67 |
MAOA | 0.66 | 0.65 |
BCKDHB | 0.65 | 0.69 |
PRCP | 0.65 | 0.65 |
TMEM22 | 0.64 | 0.62 |
VWA5A | 0.64 | 0.65 |
TSPAN33 | 0.64 | 0.70 |
ATPAF1 | 0.64 | 0.68 |
B3GALTL | 0.63 | 0.64 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
DOK5 | -0.40 | -0.16 |
PCSK9 | -0.37 | -0.31 |
LPL | -0.36 | -0.17 |
EDARADD | -0.36 | -0.32 |
TSPO | -0.36 | -0.34 |
AC005921.3 | -0.36 | -0.46 |
LHX2 | -0.35 | -0.26 |
FABP7 | -0.35 | -0.36 |
RBMX2 | -0.35 | -0.40 |
UPF3A | -0.34 | -0.36 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG NITROGEN METABOLISM | 23 | 16 | All SZGR 2.0 genes in this pathway |
REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | 12 | 6 | All SZGR 2.0 genes in this pathway |
WANG RESPONSE TO BEXAROTENE UP | 34 | 17 | All SZGR 2.0 genes in this pathway |
NIKOLSKY BREAST CANCER 16Q24 AMPLICON | 53 | 38 | All SZGR 2.0 genes in this pathway |
LEE LIVER CANCER CIPROFIBRATE DN | 66 | 43 | All SZGR 2.0 genes in this pathway |
LEE LIVER CANCER MYC TGFA DN | 65 | 44 | All SZGR 2.0 genes in this pathway |
LEE LIVER CANCER DENA DN | 74 | 45 | All SZGR 2.0 genes in this pathway |
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
GRADE COLON CANCER DN | 33 | 22 | All SZGR 2.0 genes in this pathway |
GRADE COLON AND RECTAL CANCER DN | 101 | 65 | All SZGR 2.0 genes in this pathway |
MOOTHA HUMAN MITODB 6 2002 | 429 | 260 | All SZGR 2.0 genes in this pathway |
MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
BOYAULT LIVER CANCER SUBCLASS G3 DN | 51 | 32 | All SZGR 2.0 genes in this pathway |
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN | 179 | 97 | All SZGR 2.0 genes in this pathway |
WOO LIVER CANCER RECURRENCE DN | 80 | 54 | All SZGR 2.0 genes in this pathway |
CAIRO LIVER DEVELOPMENT DN | 222 | 141 | All SZGR 2.0 genes in this pathway |
GREGORY SYNTHETIC LETHAL WITH IMATINIB | 145 | 83 | All SZGR 2.0 genes in this pathway |
OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
SERVITJA LIVER HNF1A TARGETS DN | 157 | 105 | All SZGR 2.0 genes in this pathway |