Summary ?
GeneID763
SymbolCA5A
SynonymsCA5|CA5AD|CAV|CAVA|GS1-21A4.1
Descriptioncarbonic anhydrase VA, mitochondrial
ReferenceMIM:114761|HGNC:HGNC:1377|HPRD:00262|
Gene typeprotein-coding
Map location16q24.3
Pascal p-value0.095
Fetal beta-0.276
DMG1 (# studies)
eGeneCaudate basal ganglia
Putamen basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg024729061687938341CA5A4.66E-40.1980.046DMG:Wockner_2014
cg075442231687965360CA5A5.88E-4-0.5920.05DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs133807721687906337CA5AENSG00000174990.36.364E-70.0163798gtex_brain_putamen_basal
rs353674721687913607CA5AENSG00000174990.32.535E-70.0156528gtex_brain_putamen_basal
rs593618271687916688CA5AENSG00000174990.32.619E-70.0153447gtex_brain_putamen_basal
rs74982571687919461CA5AENSG00000174990.32.819E-70.0150674gtex_brain_putamen_basal
rs48432751687920548CA5AENSG00000174990.31.812E-70.0149587gtex_brain_putamen_basal
rs48437281687921399CA5AENSG00000174990.32.792E-70.0148736gtex_brain_putamen_basal
rs616070561687921607CA5AENSG00000174990.32.789E-70.0148528gtex_brain_putamen_basal
rs72038841687923358CA5AENSG00000174990.34.676E-70.0146777gtex_brain_putamen_basal
rs118598961687925260CA5AENSG00000174990.38.264E-70.0144875gtex_brain_putamen_basal
rs567680791687930258CA5AENSG00000174990.33.375E-70.0139877gtex_brain_putamen_basal
rs558836151687931142CA5AENSG00000174990.32.923E-70.0138993gtex_brain_putamen_basal
rs80583891687931281CA5AENSG00000174990.35.841E-70.0138854gtex_brain_putamen_basal
rs3977375281687936356CA5AENSG00000174990.34.181E-70.0133779gtex_brain_putamen_basal
rs48437321687939470CA5AENSG00000174990.32.967E-80.0130665gtex_brain_putamen_basal
rs80487191687942424CA5AENSG00000174990.37.858E-80.0127711gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
INPP4B0.670.68
DDAH10.660.67
MAOA0.660.65
BCKDHB0.650.69
PRCP0.650.65
TMEM220.640.62
VWA5A0.640.65
TSPAN330.640.70
ATPAF10.640.68
B3GALTL0.630.64
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DOK5-0.40-0.16
PCSK9-0.37-0.31
LPL-0.36-0.17
EDARADD-0.36-0.32
TSPO-0.36-0.34
AC005921.3-0.36-0.46
LHX2-0.35-0.26
FABP7-0.35-0.36
RBMX2-0.35-0.40
UPF3A-0.34-0.36

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NITROGEN METABOLISM 2316All SZGR 2.0 genes in this pathway
REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE 126All SZGR 2.0 genes in this pathway
WANG RESPONSE TO BEXAROTENE UP 3417All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 16Q24 AMPLICON 5338All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN 6643All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 6544All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 7445All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
GRADE COLON CANCER DN 3322All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER DN 10165All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 DN 5132All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN 17997All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN 8054All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 14985All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway