Gene Page: ZBTB17

Summary ?
GeneID7709
SymbolZBTB17
SynonymsMIZ-1|ZNF151|ZNF60|pHZ-67
Descriptionzinc finger and BTB domain containing 17
ReferenceMIM:604084|HGNC:HGNC:12936|Ensembl:ENSG00000116809|HPRD:04968|Vega:OTTHUMG00000009377
Gene typeprotein-coding
Map location1p36.13
Pascal p-value0.465
Sherlock p-value0.813
Fetal beta0.397
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg07437033116302232ZBTB175.97E-8-0.0081.51E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZCCHC80.950.93
RAF10.950.95
MARK30.950.94
ZNF5890.940.94
REV10.940.94
TTC170.940.94
ASXL10.940.95
ZNF2110.940.93
SETDB10.930.93
ZNF5090.930.92
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.79-0.92
AF347015.27-0.78-0.90
MT-CO2-0.78-0.92
AIFM3-0.77-0.79
TSC22D4-0.76-0.82
HLA-F-0.76-0.77
AF347015.33-0.76-0.88
S100B-0.76-0.84
FXYD1-0.76-0.88
C5orf53-0.76-0.76

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)Miz1 interacts with p21WAF1 promoter.BIND15856024 
CDKN2BCDK4I | INK4B | MTS2 | P15 | TP15 | p15INK4bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)-HPRD11283613 
DDB2DDBB | FLJ34321 | UV-DDB2damage-specific DNA binding protein 2, 48kDaMiz1 interacts with DDB2 promoter.BIND15856024 
DIS3DKFZp667L1817 | EXOSC11 | FLJ10484 | KIAA1008 | MGC33035 | RP11-342J4.3 | RRP44 | bA555G22.1 | dis3pDIS3 mitotic control homolog (S. cerevisiae)-HPRD,BioGRID15231747 
DNMT3ADNMT3A2 | M.HsaIIIADNA (cytosine-5-)-methyltransferase 3 alphaAffinity Capture-WesternBioGRID15616584 
DNMT3ADNMT3A2 | M.HsaIIIADNA (cytosine-5-)-methyltransferase 3 alphaMiz-1 interacts with Dmnt3a.BIND15616584 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-WesternBioGRID11283613 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, i-HPRD12193603 
HCFC1CFF | HCF-1 | HCF1 | HFC1 | MGC70925 | VCAFhost cell factor C1 (VP16-accessory protein)-HPRD,BioGRID12244100 
HK2DKFZp686M1669 | HKII | HXK2hexokinase 2HKII interacts with Miz-1. This interaction was modeled on a demonstrated interaction between rat HKII and human Miz-1.BIND11068878 
HK3HKIII | HXK3hexokinase 3 (white cell)-HPRD,BioGRID11068878 
HK3HKIII | HXK3hexokinase 3 (white cell)HKIII amino-terminal half interacts with Miz-1. This interaction was modeled on a demonstrated interaction between rat HKIII and human Miz-1.BIND11068878 
ITGB5FLJ26658integrin, beta 5-HPRD,BioGRID12356872 
MAXMGC10775 | MGC11225 | MGC18164 | MGC34679 | MGC36767 | bHLHd4 | orf1MYC associated factor XReconstituted ComplexBioGRID11283613 
MSX2CRS2 | FPP | HOX8 | MSH | PFM | PFM1msh homeobox 2-HPRD9256341 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID9312026 
PMAIP1APR | NOXAphorbol-12-myristate-13-acetate-induced protein 1Miz1 interacts with NOXA promoter.BIND15856024 
RRM2BDKFZp686M05248 | MGC102856 | MGC42116 | p53R2ribonucleotide reductase M2 B (TP53 inducible)Miz1 interacts with p53R2 promoter.BIND15856024 
TOPBP1TOP2BP1topoisomerase (DNA) II binding protein 1-HPRD,BioGRID12408820 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL CYCLE 12884All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 8263All SZGR 2.0 genes in this pathway
PID MYC PATHWAY 2522All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 6352All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S 4634All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE 8051All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN 16193All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 7751All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION CCNE1 4026All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
LI LUNG CANCER 4130All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION DN 4430All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
SCHLINGEMANN SKIN CARCINOGENESIS TPA DN 2915All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN 209137All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN 11376All SZGR 2.0 genes in this pathway
SENGUPTA EBNA1 ANTICORRELATED 17385All SZGR 2.0 genes in this pathway