Gene Page: ZNF229
Summary ?
| GeneID | 7772 |
| Symbol | ZNF229 |
| Synonyms | - |
| Description | zinc finger protein 229 |
| Reference | HGNC:HGNC:13022|Ensembl:ENSG00000278318|HPRD:18324|Vega:OTTHUMG00000182377 |
| Gene type | protein-coding |
| Map location | 19q13.31 |
| Pascal p-value | 0.082 |
| Fetal beta | 0.683 |
| eGene | Cerebellar Hemisphere Cerebellum |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Xu_2012 | Whole Exome Sequencing analysis | De novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ZNF229 | chr19 | 44933974 | G | A | NM_014518 | p.328R>W | missense | Schizophrenia | DNM:Xu_2012 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MRPL45 | 0.95 | 0.93 |
| EIF2A | 0.93 | 0.92 |
| IGBP1 | 0.93 | 0.94 |
| GTF2B | 0.93 | 0.91 |
| CCT7 | 0.93 | 0.92 |
| CCT4 | 0.92 | 0.90 |
| PSMD14 | 0.92 | 0.88 |
| CCT8 | 0.92 | 0.92 |
| HNRNPC | 0.92 | 0.92 |
| KARS | 0.92 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.75 | -0.81 |
| AF347015.8 | -0.74 | -0.81 |
| AF347015.27 | -0.74 | -0.81 |
| MT-CYB | -0.74 | -0.81 |
| AF347015.33 | -0.73 | -0.81 |
| AF347015.31 | -0.73 | -0.80 |
| AF347015.2 | -0.73 | -0.82 |
| AF347015.15 | -0.72 | -0.80 |
| AF347015.26 | -0.70 | -0.80 |
| AF347015.21 | -0.70 | -0.79 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| ZHANG BREAST CANCER PROGENITORS UP | 425 | 253 | All SZGR 2.0 genes in this pathway |
| PASINI SUZ12 TARGETS UP | 112 | 65 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |