Summary ?
GeneID7786
SymbolMAP3K12
SynonymsDLK|MEKK12|MUK|ZPK|ZPKP1
Descriptionmitogen-activated protein kinase kinase kinase 12
ReferenceMIM:600447|HGNC:HGNC:6851|Ensembl:ENSG00000139625|HPRD:02709|Vega:OTTHUMG00000169854
Gene typeprotein-coding
Map location12q13
Pascal p-value0.014
Sherlock p-value0.443
eGeneMyers' cis & trans
SupportCompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407MAP3K1277860trans
rs3845734chr2171125572MAP3K1277860.01trans
rs7584986chr2184111432MAP3K1277860.07trans
rs17762315chr576807576MAP3K1277860.08trans
rs16955618chr1529937543MAP3K1277861.478E-7trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
JUNB0.830.63
FOXF10.800.73
APOLD10.770.72
ZFP360.760.78
DUSP10.750.62
FOS0.730.67
FOSB0.730.50
ICAM10.720.77
GADD45B0.720.61
NPAS40.720.23
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C12orf45-0.34-0.49
UCHL3-0.33-0.45
TCTEX1D2-0.33-0.48
FRG1-0.32-0.44
GTF2H5-0.32-0.41
PFDN2-0.32-0.44
MED19-0.32-0.45
PDCD5-0.32-0.47
STMN1-0.32-0.45
ZCCHC17-0.32-0.37

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY 4030All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 3125All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP 11272All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456228All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCERS KINOME BLUE 2116All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258160All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A UP 8452All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR 15288All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214124All SZGR 2.0 genes in this pathway