Gene Page: FZD5

Summary ?
GeneID7855
SymbolFZD5
SynonymsC2orf31|HFZ5
Descriptionfrizzled class receptor 5
ReferenceMIM:601723|HGNC:HGNC:4043|Ensembl:ENSG00000163251|HPRD:03427|Vega:OTTHUMG00000154790
Gene typeprotein-coding
Map location2q33.3
Pascal p-value0.083
Fetal beta-1.168
DMG1 (# studies)
eGeneCerebellar Hemisphere
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00916 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg012017972208635605FZD51.928E-40.4160.035DMG:Wockner_2014
cg053657352208635637FZD53.122E-40.4490.04DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10994209chr1061877705FZD578550.05trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS9054360 
GO:0004930G-protein coupled receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0004926non-G-protein coupled 7TM receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0016055Wnt receptor signaling pathwayIEA-
GO:0007164establishment of tissue polarityTAS8626800 
GO:0048469cell maturationIEA-
GO:0007275multicellular organismal developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneIEA-
GO:0005794Golgi apparatusIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS9054360 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 10280All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG BASAL CELL CARCINOMA 5544All SZGR 2.0 genes in this pathway
WNT SIGNALING 8971All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY 3226All SZGR 2.0 genes in this pathway
PID BETA CATENIN DEG PATHWAY 1817All SZGR 2.0 genes in this pathway
PID WNT SIGNALING PATHWAY 2823All SZGR 2.0 genes in this pathway
PID WNT CANONICAL PATHWAY 2018All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 8858All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL DN 11879All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP 13784All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186107All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR 6233All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185111All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156101All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215132All SZGR 2.0 genes in this pathway
KUNINGER IGF1 VS PDGFB TARGETS UP 8251All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 8858All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 14896All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482296All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217138All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
GU PDEF TARGETS DN 3920All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL UP 4738All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR UP 10165All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221120All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.129983004m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506299730041A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-140115011571A,m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-149126812741Ahsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-155435543611Ahsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-1917783m8hsa-miR-191brainCAACGGAAUCCCAAAAGCAGCU
miR-194373837441Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-219401540221A,m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-22438203826m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-234264331A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-24385938661A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-3234264321Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-32632763282m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-330338733931Ahsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-34234553461m8hsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-369-3p422642331A,m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-37442274233m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-375120912151Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-378*351435211A,m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-381329633021Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-384328332901A,m8hsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-421386838751A,m8hsa-miR-421GGCCUCAUUAAAUGUUUGUUG
miR-455387238791A,m8hsa-miR-455UAUGUGCCUUUGGACUACAUCG
miR-99/10038313837m8hsa-miR-99abrainAACCCGUAGAUCCGAUCUUGUG
hsa-miR-100brainAACCCGUAGAUCCGAACUUGUG
hsa-miR-99bbrainCACCCGUAGAACCGACCUUGCG