Gene Page: RAB7A

Summary ?
GeneID7879
SymbolRAB7A
SynonymsPRO2706|RAB7
DescriptionRAB7A, member RAS oncogene family
ReferenceMIM:602298|HGNC:HGNC:9788|Ensembl:ENSG00000075785|HPRD:03805|Vega:OTTHUMG00000159812
Gene typeprotein-coding
Map location3q21.3
Pascal p-value0.802
Sherlock p-value0.414
Fetal beta-0.421
DMG1 (# studies)
eGeneCerebellum
Meta
SupportINTRACELLULAR TRAFFICKING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg132840703128483832RAB7A1.525E-40.4750.032DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CHMDXS540 | FLJ38564 | GGTA | HSD-32 | MGC102710 | REP-1 | TCDchoroideremia (Rab escort protein 1)-HPRD,BioGRID9563513 |12576024 
EIF1BGC20eukaryotic translation initiation factor 1BAffinity Capture-MSBioGRID17353931 
RAB17FLJ12538RAB17, member RAS oncogene familyTwo-hybridBioGRID10329441 
RAB22AMGC16770RAB22A, member RAS oncogene familyTwo-hybridBioGRID10329441 
RAB4AHRES-1/RAB4 | RAB4RAB4A, member RAS oncogene familyTwo-hybridBioGRID10329441 
RAB4BFLJ78649 | MGC52123RAB4B, member RAS oncogene familyTwo-hybridBioGRID10329441 
RAB5ARAB5RAB5A, member RAS oncogene familyTwo-hybridBioGRID10329441 
RAB5B-RAB5B, member RAS oncogene familyTwo-hybridBioGRID10329441 
RAB6ARAB6 | RAB6A' | RAB6BRAB6A, member RAS oncogene familyTwo-hybridBioGRID10329441 
RABAC1PRA1 | PRAF1 | YIP3Rab acceptor 1 (prenylated)-HPRD10329441 
RHEBMGC111559 | RHEB2Ras homolog enriched in brainCo-localizationBioGRID15809346 
RILPFLJ31193 | PP10141Rab interacting lysosomal protein-HPRD,BioGRID11179213 
RNF115BCA2 | ZNF364ring finger protein 115-HPRD12972561 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA RAB PATHWAY 128All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 6354All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 4838All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY 3426All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION 9161All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214134All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 UP 5839All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 7751All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION CCNE1 4026All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 4 6134All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8 8657All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY UV 6243All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV 6344All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN UP 181112All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7 7646All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway