Gene Page: DDX50
Summary ?
| GeneID | 79009 |
| Symbol | DDX50 |
| Synonyms | GU2|GUB|RH-II/GuB|mcdrh |
| Description | DEAD-box helicase 50 |
| Reference | MIM:610373|HGNC:HGNC:17906|Ensembl:ENSG00000107625|HPRD:09910|Vega:OTTHUMG00000018362 |
| Gene type | protein-coding |
| Map location | 10q22.1 |
| Pascal p-value | 0.001 |
| Sherlock p-value | 0.171 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC004410.1 | 0.81 | 0.83 |
| TYK2 | 0.80 | 0.81 |
| ITFG3 | 0.80 | 0.80 |
| ATG2A | 0.78 | 0.79 |
| TMEM104 | 0.78 | 0.78 |
| ARAP1 | 0.78 | 0.78 |
| SLC12A9 | 0.78 | 0.80 |
| TRIM8 | 0.77 | 0.77 |
| TAOK2 | 0.77 | 0.78 |
| D2HGDH | 0.77 | 0.79 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.53 | -0.50 |
| SYCP3 | -0.53 | -0.48 |
| CLEC2B | -0.52 | -0.48 |
| C1orf54 | -0.52 | -0.44 |
| LY96 | -0.50 | -0.42 |
| AF347015.31 | -0.48 | -0.43 |
| AL050337.1 | -0.48 | -0.40 |
| MT1G | -0.46 | -0.37 |
| GNG11 | -0.46 | -0.41 |
| AF347015.27 | -0.45 | -0.41 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP | 206 | 111 | All SZGR 2.0 genes in this pathway |
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN | 275 | 168 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| PROVENZANI METASTASIS UP | 194 | 112 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
| YAO HOXA10 TARGETS VIA PROGESTERONE UP | 79 | 58 | All SZGR 2.0 genes in this pathway |
| IWANAGA CARCINOGENESIS BY KRAS PTEN DN | 353 | 226 | All SZGR 2.0 genes in this pathway |
| CHENG IMPRINTED BY ESTRADIOL | 110 | 68 | All SZGR 2.0 genes in this pathway |
| MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | All SZGR 2.0 genes in this pathway |
| GRADE COLON VS RECTAL CANCER UP | 38 | 21 | All SZGR 2.0 genes in this pathway |