Summary ?
GeneID79037
SymbolPVRIG
SynonymsC7orf15
Descriptionpoliovirus receptor related immunoglobulin domain containing
ReferenceHGNC:HGNC:32190|Ensembl:ENSG00000213413|Vega:OTTHUMG00000156798
Gene typeprotein-coding
Map location7q22.1
Pascal p-value0.129
Fetal beta0.059
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg13650156799970502PVRIG5.23E-65.117DMG:vanEijk_2014
cg106810657100239172PVRIG1.264E-44.919DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TP53I110.950.93
EML10.940.94
TMEM1080.940.92
GPR120.930.95
BCL90.930.94
BCORL10.930.95
FOXG1B0.930.91
DAB10.930.90
AFF30.920.94
MFHAS10.920.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SERPINB6-0.68-0.77
C5orf53-0.66-0.80
AIFM3-0.65-0.79
HEPN1-0.65-0.78
S100B-0.64-0.87
TSC22D4-0.63-0.79
AF347015.31-0.63-0.90
ALDOC-0.63-0.71
HLA-F-0.63-0.75
HSD17B14-0.63-0.79

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293193All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR DN 11469All SZGR 2.0 genes in this pathway
ZWANG DOWN BY 2ND EGF PULSE 293119All SZGR 2.0 genes in this pathway