Summary ?
GeneID79053
SymbolALG8
SynonymsCDG1H
DescriptionALG8, alpha-1,3-glucosyltransferase
ReferenceMIM:608103|HGNC:HGNC:23161|Ensembl:ENSG00000159063|HPRD:10480|Vega:OTTHUMG00000166594
Gene typeprotein-coding
Map location11q14.1
Pascal p-value0.009
Sherlock p-value0.728
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Nucleus accumbens basal ganglia
Putamen basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs96517411177746185ALG8ENSG00000159063.81.655E-60104521gtex_brain_putamen_basal
rs122732201177753705ALG8ENSG00000159063.81.617E-6097001gtex_brain_putamen_basal
rs122753991177755559ALG8ENSG00000159063.84.254E-6095147gtex_brain_putamen_basal
rs107932791177764871ALG8ENSG00000159063.82.186E-6085835gtex_brain_putamen_basal
rs355329941177767930ALG8ENSG00000159063.85.992E-7082776gtex_brain_putamen_basal
rs356699281177767948ALG8ENSG00000159063.86.065E-7082758gtex_brain_putamen_basal
rs65927621177768117ALG8ENSG00000159063.83.474E-6082589gtex_brain_putamen_basal
rs71222051177770232ALG8ENSG00000159063.86.929E-7080474gtex_brain_putamen_basal
rs112373721177771253ALG8ENSG00000159063.81.231E-6079453gtex_brain_putamen_basal
rs112373741177773926ALG8ENSG00000159063.81.237E-6076780gtex_brain_putamen_basal
rs178255721177774017ALG8ENSG00000159063.81.237E-6076689gtex_brain_putamen_basal
rs22826391177774599ALG8ENSG00000159063.81.237E-6076107gtex_brain_putamen_basal
rs108994351177777019ALG8ENSG00000159063.81.246E-6073687gtex_brain_putamen_basal
rs96517431177777188ALG8ENSG00000159063.81.246E-6073518gtex_brain_putamen_basal
rs96517441177777402ALG8ENSG00000159063.84.135E-7073304gtex_brain_putamen_basal
rs107932811177777821ALG8ENSG00000159063.84.432E-7072885gtex_brain_putamen_basal
rs107512801177784380ALG8ENSG00000159063.81.345E-6066326gtex_brain_putamen_basal
rs112373781177785453ALG8ENSG00000159063.85.03E-7065253gtex_brain_putamen_basal
rs611413941177785536ALG8ENSG00000159063.81.237E-6065170gtex_brain_putamen_basal
rs122768871177785626ALG8ENSG00000159063.84.615E-7065080gtex_brain_putamen_basal
rs122768911177785645ALG8ENSG00000159063.81.334E-6065061gtex_brain_putamen_basal
rs112373791177785957ALG8ENSG00000159063.81.237E-6064749gtex_brain_putamen_basal
rs21549631177796139ALG8ENSG00000159063.81.194E-6054567gtex_brain_putamen_basal
rs107932841177810806ALG8ENSG00000159063.83.725E-7039900gtex_brain_putamen_basal
rs107932851177811196ALG8ENSG00000159063.83.725E-7039510gtex_brain_putamen_basal
rs10752021177813207ALG8ENSG00000159063.81.293E-7037499gtex_brain_putamen_basal
rs710469551177816764ALG8ENSG00000159063.85.399E-7033942gtex_brain_putamen_basal
rs107512811177820168ALG8ENSG00000159063.83.725E-7030538gtex_brain_putamen_basal
rs108994401177825275ALG8ENSG00000159063.83.727E-7025431gtex_brain_putamen_basal
rs729465311177826985ALG8ENSG00000159063.83.907E-7023721gtex_brain_putamen_basal
rs121464881177830048ALG8ENSG00000159063.84.97E-7020658gtex_brain_putamen_basal
rs1443070721177834060ALG8ENSG00000159063.82.725E-6016646gtex_brain_putamen_basal
rs1400132891177834078ALG8ENSG00000159063.83.082E-6016628gtex_brain_putamen_basal
rs614542791177838011ALG8ENSG00000159063.84.984E-7012695gtex_brain_putamen_basal
rs122732351177842614ALG8ENSG00000159063.81.777E-708092gtex_brain_putamen_basal
rs107932871177846706ALG8ENSG00000159063.82.008E-704000gtex_brain_putamen_basal
rs107932891177850517ALG8ENSG00000159063.85.97E-70189gtex_brain_putamen_basal
rs21567851177850824ALG8ENSG00000159063.82.186E-60-118gtex_brain_putamen_basal
rs112374101177851606ALG8ENSG00000159063.85.882E-70-900gtex_brain_putamen_basal
rs584636481177852147ALG8ENSG00000159063.81.004E-60-1441gtex_brain_putamen_basal
rs71016941177853896ALG8ENSG00000159063.82.431E-70-3190gtex_brain_putamen_basal
rs12637321177858421ALG8ENSG00000159063.81.364E-60-7715gtex_brain_putamen_basal
rs12637271177862719ALG8ENSG00000159063.81.46E-60-12013gtex_brain_putamen_basal
rs12637261177864023ALG8ENSG00000159063.81.268E-60-13317gtex_brain_putamen_basal
rs9779781177865936ALG8ENSG00000159063.81.533E-60-15230gtex_brain_putamen_basal
rs40159651177866882ALG8ENSG00000159063.83.595E-60-16176gtex_brain_putamen_basal
rs12635781177867049ALG8ENSG00000159063.81.428E-60-16343gtex_brain_putamen_basal
rs12635771177869742ALG8ENSG00000159063.81.614E-60-19036gtex_brain_putamen_basal
rs11511831177870638ALG8ENSG00000159063.81.623E-60-19932gtex_brain_putamen_basal
rs285471177872876ALG8ENSG00000159063.81.623E-60-22170gtex_brain_putamen_basal
rs2306671177877369ALG8ENSG00000159063.81.658E-60-26663gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MOG0.680.47
FAM3A0.670.62
MAL0.660.45
NINJ20.660.48
ELOVL10.650.53
C12orf620.650.56
CAPN30.650.50
SNX220.650.58
INPP10.650.65
ARL20.650.64
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PBX1-0.32-0.12
EPHB1-0.32-0.17
SOX4-0.32-0.23
XPR1-0.32-0.16
ROBO1-0.31-0.10
BCL11B-0.31-0.06
ROBO2-0.30-0.09
GADL1-0.30-0.11
IGSF3-0.30-0.08
BRWD3-0.29-0.14

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG N GLYCAN BIOSYNTHESIS 4631All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 188116All SZGR 2.0 genes in this pathway
REACTOME ASPARAGINE N LINKED GLYCOSYLATION 8154All SZGR 2.0 genes in this pathway
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 2917All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 15993All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON 15893All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN 187122All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK DN 2418All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP 172109All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277172All SZGR 2.0 genes in this pathway
GUTIERREZ MULTIPLE MYELOMA UP 3524All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway