Summary ?
Descriptionproline rich coiled-coil 2A
Gene typeprotein-coding
Map location6p21.3
Pascal p-value1E-12
Sherlock p-value0.319
TADA p-value0.006
Fetal beta0.061

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI14667819 |16713569 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C1QBPGC1QBP | HABP1 | SF2p32 | gC1Q-R | gC1qR | p32complement component 1, q subcomponent binding protein-HPRD,BioGRID14667819 
CCR10GPR2chemokine (C-C motif) receptor 10-HPRD,BioGRID14667819 
CPSF1CPSF160 | HSU37012 | P/cl.18cleavage and polyadenylation specific factor 1, 160kDa-HPRD,BioGRID14667819 
DDX20DKFZp434H052 | DP103 | GEMIN3DEAD (Asp-Glu-Ala-Asp) box polypeptide 20-HPRD,BioGRID14667819 
EIF3EEIF3-P48 | EIF3S6 | INT6 | eIF3-p46eukaryotic translation initiation factor 3, subunit E-HPRD,BioGRID14667819 
FGAFib2 | MGC119422 | MGC119423 | MGC119425fibrinogen alpha chain-HPRD,BioGRID14667819 
GANABG2AN | GluII | KIAA0088glucosidase, alpha; neutral AB-HPRD,BioGRID14667819 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID14667819 
HNRNPA1HNRPA1 | MGC102835heterogeneous nuclear ribonucleoprotein A1-HPRD,BioGRID14667819 
HNRNPMDKFZp547H118 | HNRNPM4 | HNRPM | HNRPM4 | HTGR1 | NAGR1heterogeneous nuclear ribonucleoprotein M-HPRD,BioGRID14667819 
IFT88D13S1056E | DAF19 | MGC26259 | RP11-172H24.2 | TG737 | TTC10 | hTg737intraflagellar transport 88 homolog (Chlamydomonas)-HPRD,BioGRID14667819 
IMMTDKFZp779P1653 | HMP | MGC111146 | P87 | P87/89 | P89 | PIG4 | PIG52inner membrane protein, mitochondrial (mitofilin)-HPRD,BioGRID14667819 
MAD2L2MAD2B | REV7MAD2 mitotic arrest deficient-like 2 (yeast)-HPRD,BioGRID14667819 
MAN2C1DKFZp686E23167 | MAN6A8 | MANA | MANA1 | MGC87979mannosidase, alpha, class 2C, member 1-HPRD,BioGRID14667819 
P4HA2-procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II-HPRD,BioGRID14667819 
PRMT2HRMT1L1 | MGC111373protein arginine methyltransferase 2-HPRD,BioGRID14667819 
PSMA3HC8 | MGC12306 | MGC32631 | PSC3proteasome (prosome, macropain) subunit, alpha type, 3-HPRD,BioGRID14667819 
QARSGLNRS | PRO2195glutaminyl-tRNA synthetase-HPRD,BioGRID14667819 
SSR3TRAPGsignal sequence receptor, gamma (translocon-associated protein gamma)-HPRD,BioGRID14667819 
UBAP2LFLJ42300 | KIAA0144 | NICE-4ubiquitin associated protein 2-like-HPRD,BioGRID14667819 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
WILCOX RESPONSE TO PROGESTERONE DN 6644All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED DN 8647All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335193All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180101All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 14591All SZGR 2.0 genes in this pathway
LIN APC TARGETS 7755All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 12890All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 UP 4430All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 14192All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method