Gene Page: ZNF343
Summary ?
| GeneID | 79175 |
| Symbol | ZNF343 |
| Synonyms | dJ734P14.5 |
| Description | zinc finger protein 343 |
| Reference | HGNC:HGNC:16017|Ensembl:ENSG00000088876|HPRD:18327|Vega:OTTHUMG00000031701 |
| Gene type | protein-coding |
| Map location | 20p13 |
| Pascal p-value | 0.038 |
| Fetal beta | 0.903 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg13236659 | 20 | 2490040 | ZNF343 | 8.56E-9 | -0.013 | 3.98E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | ZNF343 | 79175 | 0.04 | trans | ||
| rs16955618 | chr15 | 29937543 | ZNF343 | 79175 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CCDC108 | 0.98 | 0.55 |
| CCDC19 | 0.98 | 0.47 |
| VWA3B | 0.98 | 0.47 |
| ARMC3 | 0.98 | 0.54 |
| RP11-282K6.1 | 0.98 | 0.52 |
| TCTEX1D1 | 0.97 | 0.59 |
| WDR16 | 0.97 | 0.64 |
| C3orf25 | 0.97 | 0.52 |
| YSK4 | 0.97 | 0.47 |
| DNAH9 | 0.97 | 0.60 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| IER5L | -0.17 | -0.41 |
| NDRG1 | -0.16 | -0.22 |
| CIDEA | -0.15 | -0.27 |
| SLC26A4 | -0.15 | -0.30 |
| MEF2C | -0.14 | -0.32 |
| EMX1 | -0.14 | -0.36 |
| EPHB6 | -0.14 | -0.10 |
| ARHGEF2 | -0.13 | -0.18 |
| GPR21 | -0.13 | -0.28 |
| LNX1 | -0.13 | -0.16 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 6 UP | 140 | 81 | All SZGR 2.0 genes in this pathway |
| PEDRIOLI MIR31 TARGETS DN | 418 | 245 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |