Gene Page: IRX1

Summary ?
GeneID79192
SymbolIRX1
SynonymsIRX-5|IRXA1
Descriptioniroquois homeobox 1
ReferenceMIM:606197|HGNC:HGNC:14358|Ensembl:ENSG00000170549|HPRD:16203|Vega:OTTHUMG00000161632
Gene typeprotein-coding
Map location5p15.3
Pascal p-value0.014
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:McCarthy_2014Whole Exome Sequencing analysisWhole exome sequencing of 57 trios with sporadic or familial schizophrenia.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
IRX1chr53601122CGNM_024337p.P471Amissense SNVCPSchizophreniaDNM:McCarthy_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16827839chr2150987417IRX1791920.12trans
rs16829545chr2151977407IRX1791920.02trans
rs7584986chr2184111432IRX1791920.01trans
rs1981925chr434348578IRX1791920.01trans
rs10491487chr580323367IRX1791920.02trans
rs7713523chr597248325IRX1791920.15trans
rs2268637chr639050917IRX1791920.16trans
rs17160028chr731292738IRX1791920.16trans
rs1976192chr9117074359IRX1791920.01trans
rs17410931chr1098912175IRX1791920.05trans
rs10500981chr1124543474IRX1791920.19trans
rs17129612chr1196658135IRX1791920.18trans
rs11044062chr128371319IRX1791920.18trans
rs11106191chr1278060911IRX1791920.11trans
rs2145444chr1452005406IRX1791920.16trans
rs16955618chr1529937543IRX1791921.214E-5trans
rs12599961chr168443409IRX1791920.19trans
rs16944856chr1711394566IRX1791920.08trans
rs1541352chr1713265560IRX1791920.09trans
rs17070739chr1860819382IRX1791920.14trans
rs7268640chr2047150267IRX1791920.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL DN 9153All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271175All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 11078All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185111All SZGR 2.0 genes in this pathway
NOUZOVA METHYLATED IN APL 6839All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 9772All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
GYORFFY MITOXANTRONE RESISTANCE 5735All SZGR 2.0 genes in this pathway
KORKOLA EMBRYONIC CARCINOMA VS SEMINOMA DN 2514All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275155All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN 9974All SZGR 2.0 genes in this pathway