Summary ?
GeneID79570
SymbolNKAIN1
SynonymsFAM77C
DescriptionNa+/K+ transporting ATPase interacting 1
ReferenceMIM:612871|HGNC:HGNC:25743|Ensembl:ENSG00000084628|HPRD:07786|Vega:OTTHUMG00000003788
Gene typeprotein-coding
Map location1p35.2
Pascal p-value2.366E-4
Sherlock p-value0.881
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4949356chr131653987NKAIN1795700.02cis
snp_a-19167800NKAIN1795700.16trans
rs16829545chr2151977407NKAIN1795700trans
rs3845734chr2171125572NKAIN1795700.13trans
rs2183142chr4159232695NKAIN1795700.02trans
rs16955618chr1529937543NKAIN1795702.096E-6trans
rs6425714131653733NKAIN1ENSG00000084628.52.836E-60.0158668gtex_brain_ba24
rs6425715131658678NKAIN1ENSG00000084628.53.599E-60.0153723gtex_brain_ba24
rs6693735131659496NKAIN1ENSG00000084628.53.322E-60.0152905gtex_brain_ba24
rs61778275131663833NKAIN1ENSG00000084628.52.525E-60.0148568gtex_brain_ba24
rs11580143131668115NKAIN1ENSG00000084628.51.93E-60.0144286gtex_brain_ba24
rs6688565131674399NKAIN1ENSG00000084628.52.807E-60.0138002gtex_brain_ba24
rs6672056131688111NKAIN1ENSG00000084628.51.333E-60.0124290gtex_brain_ba24
rs10798831131688385NKAIN1ENSG00000084628.51.076E-60.0124016gtex_brain_ba24
rs10914328131688406NKAIN1ENSG00000084628.51.076E-60.0123995gtex_brain_ba24
rs10914329131688441NKAIN1ENSG00000084628.51.076E-60.0123960gtex_brain_ba24
rs10798832131688630NKAIN1ENSG00000084628.51.076E-60.0123771gtex_brain_ba24
rs7520439131688721NKAIN1ENSG00000084628.51.076E-60.0123680gtex_brain_ba24
rs7520468131688812NKAIN1ENSG00000084628.51.076E-60.0123589gtex_brain_ba24
rs7544003131689088NKAIN1ENSG00000084628.51.087E-60.0123313gtex_brain_ba24
rs6703593131689284NKAIN1ENSG00000084628.51.161E-60.0123117gtex_brain_ba24
rs6660276131689543NKAIN1ENSG00000084628.51.075E-60.0122858gtex_brain_ba24
rs60073066131689589NKAIN1ENSG00000084628.51.077E-60.0122812gtex_brain_ba24
rs12136121131689743NKAIN1ENSG00000084628.51.087E-60.0122658gtex_brain_ba24
rs2185421131689808NKAIN1ENSG00000084628.51.093E-60.0122593gtex_brain_ba24
rs2153453131689859NKAIN1ENSG00000084628.51.517E-60.0122542gtex_brain_ba24
rs2153452131689965NKAIN1ENSG00000084628.52.602E-60.0122436gtex_brain_ba24
rs10914333131701491NKAIN1ENSG00000084628.55.738E-70.0110910gtex_brain_ba24
rs12136293131703650NKAIN1ENSG00000084628.51.066E-60.018751gtex_brain_ba24
rs12139732131703824NKAIN1ENSG00000084628.51.118E-60.018577gtex_brain_ba24
rs10798825131639834NKAIN1ENSG00000084628.59.641E-10072567gtex_brain_putamen_basal
rs12021862131640274NKAIN1ENSG00000084628.54.522E-12072127gtex_brain_putamen_basal
rs11588285131641614NKAIN1ENSG00000084628.51.959E-12070787gtex_brain_putamen_basal
rs61778267131644238NKAIN1ENSG00000084628.52.115E-13068163gtex_brain_putamen_basal
rs11577241131647583NKAIN1ENSG00000084628.52.431E-13064818gtex_brain_putamen_basal
rs9726313131648645NKAIN1ENSG00000084628.53.821E-13063756gtex_brain_putamen_basal
rs2066163131650749NKAIN1ENSG00000084628.51.437E-13061652gtex_brain_putamen_basal
rs2153451131650819NKAIN1ENSG00000084628.51.437E-13061582gtex_brain_putamen_basal
rs12034764131651097NKAIN1ENSG00000084628.51.437E-13061304gtex_brain_putamen_basal
rs6425714131653733NKAIN1ENSG00000084628.59.058E-10058668gtex_brain_putamen_basal
rs4949356131653988NKAIN1ENSG00000084628.51.437E-13058413gtex_brain_putamen_basal
rs4949357131654305NKAIN1ENSG00000084628.55.468E-13058096gtex_brain_putamen_basal
rs2297959131654940NKAIN1ENSG00000084628.56.75E-14057461gtex_brain_putamen_basal
rs6425715131658678NKAIN1ENSG00000084628.54.529E-14053723gtex_brain_putamen_basal
rs6703564131659124NKAIN1ENSG00000084628.53.22E-7053277gtex_brain_putamen_basal
rs6693735131659496NKAIN1ENSG00000084628.55.506E-14052905gtex_brain_putamen_basal
rs35077499131661921NKAIN1ENSG00000084628.54.619E-7050480gtex_brain_putamen_basal
rs4375319131662225NKAIN1ENSG00000084628.51.495E-9050176gtex_brain_putamen_basal
rs61778275131663833NKAIN1ENSG00000084628.52.331E-15048568gtex_brain_putamen_basal
rs201791316131665906NKAIN1ENSG00000084628.52.897E-11046495gtex_brain_putamen_basal
rs200247345131665908NKAIN1ENSG00000084628.51.79E-14046493gtex_brain_putamen_basal
rs79918429131665909NKAIN1ENSG00000084628.51.045E-14046492gtex_brain_putamen_basal
rs60881573131667202NKAIN1ENSG00000084628.51.099E-6045199gtex_brain_putamen_basal
rs35056890131667679NKAIN1ENSG00000084628.55.673E-10044722gtex_brain_putamen_basal
rs11580143131668115NKAIN1ENSG00000084628.51.067E-14044286gtex_brain_putamen_basal
rs12122727131669135NKAIN1ENSG00000084628.58.271E-10043266gtex_brain_putamen_basal
rs10798826131669803NKAIN1ENSG00000084628.52.275E-9042598gtex_brain_putamen_basal
rs6665296131670997NKAIN1ENSG00000084628.51.141E-8041404gtex_brain_putamen_basal
rs6677966131671059NKAIN1ENSG00000084628.51.207E-8041342gtex_brain_putamen_basal
rs1316588131671375NKAIN1ENSG00000084628.51.167E-8041026gtex_brain_putamen_basal
rs1316587131671435NKAIN1ENSG00000084628.57.153E-9040966gtex_brain_putamen_basal
rs1316589131671446NKAIN1ENSG00000084628.59.582E-9040955gtex_brain_putamen_basal
rs12119504131671911NKAIN1ENSG00000084628.56.382E-10040490gtex_brain_putamen_basal
rs7545480131672166NKAIN1ENSG00000084628.55.756E-9040235gtex_brain_putamen_basal
rs946887131672331NKAIN1ENSG00000084628.51.699E-9040070gtex_brain_putamen_basal
rs946886131672443NKAIN1ENSG00000084628.51.219E-9039958gtex_brain_putamen_basal
rs946885131672466NKAIN1ENSG00000084628.51.082E-9039935gtex_brain_putamen_basal
rs946884131672701NKAIN1ENSG00000084628.56.027E-10039700gtex_brain_putamen_basal
rs946883131672761NKAIN1ENSG00000084628.55.6E-10039640gtex_brain_putamen_basal
rs2377721131672909NKAIN1ENSG00000084628.51.446E-8039492gtex_brain_putamen_basal
rs2377720131673003NKAIN1ENSG00000084628.53.674E-10039398gtex_brain_putamen_basal
rs2377719131673046NKAIN1ENSG00000084628.53.288E-10039355gtex_brain_putamen_basal
rs2377718131673116NKAIN1ENSG00000084628.53.18E-10039285gtex_brain_putamen_basal
rs2377717131673263NKAIN1ENSG00000084628.52.77E-10039138gtex_brain_putamen_basal
rs2377715131673401NKAIN1ENSG00000084628.52.624E-10039000gtex_brain_putamen_basal
rs2050819131673603NKAIN1ENSG00000084628.52.629E-10038798gtex_brain_putamen_basal
rs2050818131673876NKAIN1ENSG00000084628.52.641E-10038525gtex_brain_putamen_basal
rs6688565131674399NKAIN1ENSG00000084628.52.714E-10038002gtex_brain_putamen_basal
rs2050817131674979NKAIN1ENSG00000084628.52.675E-10037422gtex_brain_putamen_basal
rs10914316131675240NKAIN1ENSG00000084628.52.675E-10037161gtex_brain_putamen_basal
rs10914317131675270NKAIN1ENSG00000084628.52.675E-10037131gtex_brain_putamen_basal
rs10914318131675417NKAIN1ENSG00000084628.51.168E-9036984gtex_brain_putamen_basal
rs10914319131675432NKAIN1ENSG00000084628.52.949E-9036969gtex_brain_putamen_basal
rs12030828131675499NKAIN1ENSG00000084628.53.604E-10036902gtex_brain_putamen_basal
rs12031630131675681NKAIN1ENSG00000084628.52.2E-14036720gtex_brain_putamen_basal
rs10914320131675859NKAIN1ENSG00000084628.52.04E-9036542gtex_brain_putamen_basal
rs12123713131675980NKAIN1ENSG00000084628.54.355E-9036421gtex_brain_putamen_basal
rs4949197131676938NKAIN1ENSG00000084628.52.772E-10035463gtex_brain_putamen_basal
rs4949358131677346NKAIN1ENSG00000084628.52.729E-10035055gtex_brain_putamen_basal
rs4949359131678047NKAIN1ENSG00000084628.51.997E-10034354gtex_brain_putamen_basal
rs4949360131678238NKAIN1ENSG00000084628.52.493E-10034163gtex_brain_putamen_basal
rs4949361131678291NKAIN1ENSG00000084628.52.66E-10034110gtex_brain_putamen_basal
rs61778329131678405NKAIN1ENSG00000084628.52.626E-10033996gtex_brain_putamen_basal
rs61778330131678626NKAIN1ENSG00000084628.53.057E-21033775gtex_brain_putamen_basal
rs67779751131679118NKAIN1ENSG00000084628.53.055E-10033283gtex_brain_putamen_basal
rs11805687131679829NKAIN1ENSG00000084628.52.618E-21032572gtex_brain_putamen_basal
rs7549197131681014NKAIN1ENSG00000084628.55.013E-18031387gtex_brain_putamen_basal
rs397715016131681190NKAIN1ENSG00000084628.55.011E-18031211gtex_brain_putamen_basal
rs202124168131681476NKAIN1ENSG00000084628.54.323E-13030925gtex_brain_putamen_basal
rs61217134131681482NKAIN1ENSG00000084628.52.77E-10030919gtex_brain_putamen_basal
rs12036862131681547NKAIN1ENSG00000084628.52.454E-10030854gtex_brain_putamen_basal
rs4949198131681614NKAIN1ENSG00000084628.52.562E-21030787gtex_brain_putamen_basal
rs10914324131682035NKAIN1ENSG00000084628.55.014E-18030366gtex_brain_putamen_basal
rs10914325131682039NKAIN1ENSG00000084628.55.014E-18030362gtex_brain_putamen_basal
rs10798827131682312NKAIN1ENSG00000084628.52.77E-10030089gtex_brain_putamen_basal
rs2889710131682380NKAIN1ENSG00000084628.55.036E-18030021gtex_brain_putamen_basal
rs2377714131682601NKAIN1ENSG00000084628.52.77E-10029800gtex_brain_putamen_basal
rs2095993131682702NKAIN1ENSG00000084628.52.77E-10029699gtex_brain_putamen_basal
rs1110122131683175NKAIN1ENSG00000084628.57.348E-18029226gtex_brain_putamen_basal
rs66690593131683285NKAIN1ENSG00000084628.51.829E-9029116gtex_brain_putamen_basal
rs10737355131683480NKAIN1ENSG00000084628.55.084E-18028921gtex_brain_putamen_basal
rs10737356131683489NKAIN1ENSG00000084628.54.807E-13028912gtex_brain_putamen_basal
rs10753244131683500NKAIN1ENSG00000084628.54.807E-13028901gtex_brain_putamen_basal
rs10798828131683890NKAIN1ENSG00000084628.52.659E-10028511gtex_brain_putamen_basal
rs10798829131684013NKAIN1ENSG00000084628.54.22E-13028388gtex_brain_putamen_basal
rs4949363131684686NKAIN1ENSG00000084628.52.857E-13027715gtex_brain_putamen_basal
rs4949199131684775NKAIN1ENSG00000084628.51.003E-12027626gtex_brain_putamen_basal
rs4949364131685071NKAIN1ENSG00000084628.52.283E-13027330gtex_brain_putamen_basal
rs6695349131685180NKAIN1ENSG00000084628.52.136E-13027221gtex_brain_putamen_basal
rs200935055131685252NKAIN1ENSG00000084628.51.942E-10027149gtex_brain_putamen_basal
rs12032979131685253NKAIN1ENSG00000084628.52.049E-11027148gtex_brain_putamen_basal
rs60753218131685266NKAIN1ENSG00000084628.52.062E-13027135gtex_brain_putamen_basal
rs6664644131685498NKAIN1ENSG00000084628.51.45E-10026903gtex_brain_putamen_basal
rs11587553131685573NKAIN1ENSG00000084628.54.223E-11026828gtex_brain_putamen_basal
rs11587554131685574NKAIN1ENSG00000084628.57.11E-11026827gtex_brain_putamen_basal
rs61778332131685585NKAIN1ENSG00000084628.51.614E-10026816gtex_brain_putamen_basal
rs11584136131685616NKAIN1ENSG00000084628.52.904E-19026785gtex_brain_putamen_basal
rs11582785131685768NKAIN1ENSG00000084628.51.544E-13026633gtex_brain_putamen_basal
rs12033154131686085NKAIN1ENSG00000084628.51.302E-13026316gtex_brain_putamen_basal
rs72510622131686282NKAIN1ENSG00000084628.59.91E-14026119gtex_brain_putamen_basal
rs12752431131686527NKAIN1ENSG00000084628.55.931E-14025874gtex_brain_putamen_basal
rs12033303131686538NKAIN1ENSG00000084628.55.74E-14025863gtex_brain_putamen_basal
rs35231692131686584NKAIN1ENSG00000084628.54.63E-14025817gtex_brain_putamen_basal
rs34265582131686676NKAIN1ENSG00000084628.53.218E-14025725gtex_brain_putamen_basal
rs10798830131686883NKAIN1ENSG00000084628.56.549E-13025518gtex_brain_putamen_basal
rs10914327131688149NKAIN1ENSG00000084628.51.34E-6024252gtex_brain_putamen_basal
rs7543900131688961NKAIN1ENSG00000084628.56.629E-7023440gtex_brain_putamen_basal
rs12748874131690407NKAIN1ENSG00000084628.54.929E-7021994gtex_brain_putamen_basal
rs2050815131690539NKAIN1ENSG00000084628.51.564E-7021862gtex_brain_putamen_basal
rs4949365131690861NKAIN1ENSG00000084628.51.649E-8021540gtex_brain_putamen_basal
rs34251716131690883NKAIN1ENSG00000084628.52.871E-6021518gtex_brain_putamen_basal
rs6672915131691361NKAIN1ENSG00000084628.51.502E-7021040gtex_brain_putamen_basal
rs10914330131691577NKAIN1ENSG00000084628.51.031E-6020824gtex_brain_putamen_basal
rs12079944131692242NKAIN1ENSG00000084628.51.431E-7020159gtex_brain_putamen_basal
rs6425717131694103NKAIN1ENSG00000084628.51.36E-7018298gtex_brain_putamen_basal
rs6674677131694314NKAIN1ENSG00000084628.56.864E-8018087gtex_brain_putamen_basal
rs6662203131694470NKAIN1ENSG00000084628.51.249E-7017931gtex_brain_putamen_basal
rs7523841131696437NKAIN1ENSG00000084628.51.267E-7015964gtex_brain_putamen_basal
rs7545649131696493NKAIN1ENSG00000084628.51.268E-7015908gtex_brain_putamen_basal
rs10914331131696581NKAIN1ENSG00000084628.51.248E-7015820gtex_brain_putamen_basal
rs7546080131696977NKAIN1ENSG00000084628.51.248E-7015424gtex_brain_putamen_basal
rs2377732131697284NKAIN1ENSG00000084628.51.248E-7015117gtex_brain_putamen_basal
rs881882131697370NKAIN1ENSG00000084628.51.239E-7015031gtex_brain_putamen_basal
rs2377731131697471NKAIN1ENSG00000084628.51.238E-7014930gtex_brain_putamen_basal
rs2889713131697751NKAIN1ENSG00000084628.51.233E-7014650gtex_brain_putamen_basal
rs2377730131697779NKAIN1ENSG00000084628.51.233E-7014622gtex_brain_putamen_basal
rs1970432131697912NKAIN1ENSG00000084628.51.575E-7014489gtex_brain_putamen_basal
rs2377729131697966NKAIN1ENSG00000084628.53.663E-7014435gtex_brain_putamen_basal
rs201489723131698277NKAIN1ENSG00000084628.52.294E-6014124gtex_brain_putamen_basal
rs11412250131698279NKAIN1ENSG00000084628.52.313E-6014122gtex_brain_putamen_basal
rs7525003131698455NKAIN1ENSG00000084628.59.218E-8013946gtex_brain_putamen_basal
rs7513300131698466NKAIN1ENSG00000084628.59.218E-8013935gtex_brain_putamen_basal
rs7513301131698473NKAIN1ENSG00000084628.59.218E-8013928gtex_brain_putamen_basal
rs202091998131698569NKAIN1ENSG00000084628.51.224E-7013832gtex_brain_putamen_basal
rs11412251131698571NKAIN1ENSG00000084628.51.223E-7013830gtex_brain_putamen_basal
rs16834266131698668NKAIN1ENSG00000084628.51.223E-7013733gtex_brain_putamen_basal
rs56125362131698765NKAIN1ENSG00000084628.51.22E-7013636gtex_brain_putamen_basal
rs10914332131699002NKAIN1ENSG00000084628.51.056E-6013399gtex_brain_putamen_basal
rs7528098131699435NKAIN1ENSG00000084628.51.215E-7012966gtex_brain_putamen_basal
rs12562438131699830NKAIN1ENSG00000084628.51.056E-6012571gtex_brain_putamen_basal
rs12087046131700412NKAIN1ENSG00000084628.52.676E-6011989gtex_brain_putamen_basal
rs71028749131700493NKAIN1ENSG00000084628.51.541E-7011908gtex_brain_putamen_basal
rs6425719131700777NKAIN1ENSG00000084628.51.858E-7011624gtex_brain_putamen_basal
rs7534957131701870NKAIN1ENSG00000084628.56.629E-7010531gtex_brain_putamen_basal
rs7523406131701947NKAIN1ENSG00000084628.56.629E-7010454gtex_brain_putamen_basal
rs1107427131701981NKAIN1ENSG00000084628.51.248E-7010420gtex_brain_putamen_basal
rs6699372131704333NKAIN1ENSG00000084628.51.579E-808068gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
DAVICIONI MOLECULAR ARMS VS ERMS UP 332228All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION DN 4831All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 8550All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP 172109All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238145All SZGR 2.0 genes in this pathway
TAVAZOIE METASTASIS 10868All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 14386All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway