Gene Page: FASTKD1
Summary ?
| GeneID | 79675 |
| Symbol | FASTKD1 |
| Synonyms | - |
| Description | FAST kinase domains 1 |
| Reference | HGNC:HGNC:26150|Ensembl:ENSG00000138399|HPRD:07969|Vega:OTTHUMG00000154953 |
| Gene type | protein-coding |
| Map location | 2q31 |
| Pascal p-value | 0.155 |
| Sherlock p-value | 0.116 |
| Fetal beta | 0.434 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Cerebellum Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg23928435 | 2 | 170430788 | FASTKD1 | 3.672E-4 | 0.442 | 0.042 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs112651521 | 2 | 170346004 | FASTKD1 | ENSG00000138399.13 | 7.701E-8 | 0 | 84381 | gtex_brain_putamen_basal |
| rs7349274 | 2 | 170386294 | FASTKD1 | ENSG00000138399.13 | 2.144E-8 | 0 | 44091 | gtex_brain_putamen_basal |
| rs73037961 | 2 | 170389032 | FASTKD1 | ENSG00000138399.13 | 2.144E-8 | 0 | 41353 | gtex_brain_putamen_basal |
| rs16857020 | 2 | 170390189 | FASTKD1 | ENSG00000138399.13 | 2.144E-8 | 0 | 40196 | gtex_brain_putamen_basal |
| rs79371451 | 2 | 170399190 | FASTKD1 | ENSG00000138399.13 | 1.596E-8 | 0 | 31195 | gtex_brain_putamen_basal |
| rs12470809 | 2 | 170401673 | FASTKD1 | ENSG00000138399.13 | 2.399E-8 | 0 | 28712 | gtex_brain_putamen_basal |
| rs2290010 | 2 | 170402752 | FASTKD1 | ENSG00000138399.13 | 3.265E-8 | 0 | 27633 | gtex_brain_putamen_basal |
| rs12620049 | 2 | 170404926 | FASTKD1 | ENSG00000138399.13 | 3.265E-8 | 0 | 25459 | gtex_brain_putamen_basal |
| rs79936507 | 2 | 170409031 | FASTKD1 | ENSG00000138399.13 | 3.265E-8 | 0 | 21354 | gtex_brain_putamen_basal |
| rs76216336 | 2 | 170409372 | FASTKD1 | ENSG00000138399.13 | 3.265E-8 | 0 | 21013 | gtex_brain_putamen_basal |
| rs12475814 | 2 | 170410165 | FASTKD1 | ENSG00000138399.13 | 3.281E-7 | 0 | 20220 | gtex_brain_putamen_basal |
| rs12475958 | 2 | 170410415 | FASTKD1 | ENSG00000138399.13 | 3.265E-8 | 0 | 19970 | gtex_brain_putamen_basal |
| rs12478568 | 2 | 170414166 | FASTKD1 | ENSG00000138399.13 | 3.265E-8 | 0 | 16219 | gtex_brain_putamen_basal |
| rs12052238 | 2 | 170415441 | FASTKD1 | ENSG00000138399.13 | 3.265E-8 | 0 | 14944 | gtex_brain_putamen_basal |
| rs16857042 | 2 | 170419108 | FASTKD1 | ENSG00000138399.13 | 3.265E-8 | 0 | 11277 | gtex_brain_putamen_basal |
| rs12467047 | 2 | 170427222 | FASTKD1 | ENSG00000138399.13 | 7.802E-7 | 0 | 3163 | gtex_brain_putamen_basal |
| rs746271 | 2 | 170429975 | FASTKD1 | ENSG00000138399.13 | 7.904E-7 | 0 | 410 | gtex_brain_putamen_basal |
| rs2353192 | 2 | 170430388 | FASTKD1 | ENSG00000138399.13 | 7.904E-7 | 0 | -3 | gtex_brain_putamen_basal |
| rs79330162 | 2 | 170432599 | FASTKD1 | ENSG00000138399.13 | 4.303E-7 | 0 | -2214 | gtex_brain_putamen_basal |
| rs77692577 | 2 | 170433867 | FASTKD1 | ENSG00000138399.13 | 4.4E-7 | 0 | -3482 | gtex_brain_putamen_basal |
| rs2353193 | 2 | 170434063 | FASTKD1 | ENSG00000138399.13 | 4.4E-7 | 0 | -3678 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| SENGUPTA NASOPHARYNGEAL CARCINOMA UP | 294 | 178 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP | 204 | 140 | All SZGR 2.0 genes in this pathway |
| TIEN INTESTINE PROBIOTICS 24HR UP | 557 | 331 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA DN | 284 | 156 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS DN | 459 | 276 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| KIM MYC AMPLIFICATION TARGETS UP | 201 | 127 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS UP | 388 | 234 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO CSF2RB AND IL4 UP | 338 | 225 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF UP | 418 | 282 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP | 408 | 276 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS | 535 | 325 | All SZGR 2.0 genes in this pathway |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | 277 | 172 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC ICP WITH H3K4ME3 | 445 | 257 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |