Gene Page: OGFOD2

Summary ?
GeneID79676
SymbolOGFOD2
Synonyms-
Description2-oxoglutarate and iron dependent oxygenase domain containing 2
ReferenceHGNC:HGNC:25823|Ensembl:ENSG00000111325|HPRD:07829|Vega:OTTHUMG00000168778
Gene typeprotein-coding
Map location12q24.31
Pascal p-value1.27E-10
Sherlock p-value0.066
Fetal beta-1.069
eGeneHypothalamus
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
LK:YESGenome-wide Association StudyThis data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4275659chr12123447927OGFOD2796760.01cis
rs1106240chr12123626981OGFOD2796760.03cis
rs1569068chr12123632275OGFOD2796760.02cis
rs1727315chr12123638929OGFOD2796760.01cis
rs1727313chr12123640852OGFOD2796760.03cis
rs1716168chr12123651965OGFOD2796760.02cis
rs2695478chr12123689520OGFOD2796760cis
rs1609520chr12123735936OGFOD2796760.02cis
rs10846489chr12123743926OGFOD2796760.03cis
rs2695478chr12123689520OGFOD2796760.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TMEM670.890.63
EFHC10.880.60
C3orf150.880.64
CCDC400.880.59
LRP2BP0.880.37
CCDC1460.880.66
DNAH60.870.61
TTC250.860.58
CCDC810.850.51
HYDIN0.850.66
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.31-0.46
AF347015.27-0.31-0.45
PTGDS-0.31-0.38
AF347015.31-0.31-0.47
COX4I2-0.30-0.46
HLA-F-0.30-0.37
AF347015.33-0.30-0.44
ALDH1A1-0.30-0.43
MT-CYB-0.30-0.45
CA4-0.30-0.39

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276165All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341197All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165107All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180110All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181107All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS DN 5234All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220133All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway