Gene Page: MICALL2
Summary ?
| GeneID | 79778 |
| Symbol | MICALL2 |
| Synonyms | JRAB|MICAL-L2 |
| Description | MICAL like 2 |
| Reference | HGNC:HGNC:29672|Ensembl:ENSG00000164877|HPRD:11364|Vega:OTTHUMG00000119021 |
| Gene type | protein-coding |
| Map location | 7p22.3 |
| Pascal p-value | 0.574 |
| Sherlock p-value | 0.274 |
| Fetal beta | 0.406 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg02492818 | 7 | 1493153 | MICALL2 | 1.075E-4 | 0.494 | 0.028 | DMG:Wockner_2014 |
| cg16857641 | 7 | 1492452 | MICALL2 | 1.771E-4 | 0.589 | 0.034 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PDS5B | 0.80 | 0.83 |
| BAI3 | 0.76 | 0.80 |
| AFTPH | 0.76 | 0.81 |
| ZNF667 | 0.75 | 0.79 |
| ADSS | 0.75 | 0.78 |
| SLC6A15 | 0.75 | 0.79 |
| WDR44 | 0.75 | 0.78 |
| HECTD2 | 0.74 | 0.79 |
| RPGRIP1L | 0.74 | 0.80 |
| PRKCI | 0.73 | 0.79 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.65 | -0.66 |
| FXYD1 | -0.64 | -0.65 |
| AF347015.31 | -0.63 | -0.65 |
| MT-CYB | -0.63 | -0.64 |
| AF347015.8 | -0.63 | -0.65 |
| CST3 | -0.62 | -0.66 |
| HIGD1B | -0.62 | -0.66 |
| HSD17B14 | -0.62 | -0.65 |
| AF347015.21 | -0.62 | -0.63 |
| AF347015.33 | -0.62 | -0.60 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DOANE RESPONSE TO ANDROGEN UP | 184 | 125 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| PEREZ TP63 TARGETS | 355 | 243 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 AND TP63 TARGETS | 205 | 145 | All SZGR 2.0 genes in this pathway |
| FALVELLA SMOKERS WITH LUNG CANCER | 80 | 52 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 7P22 AMPLICON | 38 | 27 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY NO BLOOD UP | 222 | 139 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY UP | 487 | 303 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS UP | 317 | 208 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS SILENCED BY METHYLATION UP | 461 | 298 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR | 152 | 88 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| WARTERS RESPONSE TO IR SKIN | 83 | 44 | All SZGR 2.0 genes in this pathway |