Summary ?
GeneID79786
SymbolKLHL36
SynonymsC16orf44
Descriptionkelch like family member 36
ReferenceHGNC:HGNC:17844|HPRD:12675|
Gene typeprotein-coding
Map location16q24.1
Pascal p-value0.04
Sherlock p-value0.892
DMG1 (# studies)
eGeneHippocampus
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg069458451684681510KLHL364.637E-40.3210.046DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs11865946chr1683689142KLHL36797860.15cis
rs443832chr1683779643KLHL36797860.05cis
rs727975101684690467KLHL36ENSG00000135686.81.056E-60.018336gtex_brain_putamen_basal
rs37517621684691044KLHL36ENSG00000135686.82.259E-70.018913gtex_brain_putamen_basal
rs124449111684691823KLHL36ENSG00000135686.81.044E-60.019692gtex_brain_putamen_basal
rs111496711684693084KLHL36ENSG00000135686.83.406E-70.0110953gtex_brain_putamen_basal
rs111496721684693099KLHL36ENSG00000135686.83.382E-70.0110968gtex_brain_putamen_basal
rs93194521684693879KLHL36ENSG00000135686.82.602E-70.0111748gtex_brain_putamen_basal
rs80533241684694180KLHL36ENSG00000135686.81.126E-60.0112049gtex_brain_putamen_basal
rs80533341684694198KLHL36ENSG00000135686.83.713E-70.0112067gtex_brain_putamen_basal
rs620488001684700219KLHL36ENSG00000135686.82.316E-70.0118088gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
WDR40C0.710.76
LRRN30.660.66
PCDHGC40.650.70
LTB4R20.650.62
EFNB30.640.73
GPRIN10.640.72
PIK3R20.640.73
C12orf680.640.71
ANKRD570.630.72
PCDHAC10.630.69
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
S100B-0.47-0.60
HLA-F-0.46-0.57
FXYD1-0.46-0.60
MT-CO2-0.46-0.61
SEPT4-0.45-0.56
PAQR6-0.45-0.58
S100A1-0.45-0.61
AF347015.33-0.44-0.60
CYP2J2-0.44-0.58
PIR-0.44-0.58

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
LEIN MEDULLA MARKERS 8148All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN 204114All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway