Gene Page: ZNF408
Summary ?
| GeneID | 79797 |
| Symbol | ZNF408 |
| Synonyms | EVR6|RP72 |
| Description | zinc finger protein 408 |
| Reference | MIM:616454|HGNC:HGNC:20041|Ensembl:ENSG00000175213|HPRD:18338|Vega:OTTHUMG00000166568 |
| Gene type | protein-coding |
| Map location | 11p11.2 |
| Pascal p-value | 2.124E-8 |
| Sherlock p-value | 0.631 |
| eGene | Caudate basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Expression | Meta-analysis of gene expression | P value: 1.523 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0086 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2166458 | chr2 | 215716168 | ZNF408 | 79797 | 0.1 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003677 | DNA binding | IEA | - | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO:0042802 | identical protein binding | IPI | 15231747 | |
| GO:0046872 | metal ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0006350 | transcription | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005622 | intracellular | IEA | - | |
| GO:0005634 | nucleus | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CALCOCO2 | MGC17318 | NDP52 | calcium binding and coiled-coil domain 2 | Two-hybrid | BioGRID | 16189514 |
| CEP70 | BITE | FLJ13036 | centrosomal protein 70kDa | Two-hybrid | BioGRID | 16189514 |
| DVL3 | KIAA0208 | dishevelled, dsh homolog 3 (Drosophila) | Two-hybrid | BioGRID | 16189514 |
| KHDRBS3 | Etle | SALP | SLM-2 | SLM2 | T-STAR | TSTAR | etoile | KH domain containing, RNA binding, signal transduction associated 3 | Two-hybrid | BioGRID | 16189514 |
| KRTAP4-12 | KAP4.12 | KRTAP4.12 | keratin associated protein 4-12 | Two-hybrid | BioGRID | 16189514 |
| LDOC1 | BCUR1 | Mar7 | Mart7 | leucine zipper, down-regulated in cancer 1 | Two-hybrid | BioGRID | 16189514 |
| LSM2 | C6orf28 | G7b | YBL026W | snRNP | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | - | HPRD | 14667819 |
| MDFI | I-MF | I-mfa | MyoD family inhibitor | Two-hybrid | BioGRID | 16189514 |
| MIF | GIF | GLIF | MMIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | - | HPRD | 15231747 |
| RALYL | HNRPCL3 | RALY RNA binding protein-like | Two-hybrid | BioGRID | 16189514 |
| THAP1 | FLJ10477 | MGC33014 | THAP domain containing, apoptosis associated protein 1 | Two-hybrid | BioGRID | 16189514 |
| ZBTB8 | BOZF1 | FLJ90065 | MGC17919 | zinc finger and BTB domain containing 8 | Two-hybrid | BioGRID | 16189514 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ROVERSI GLIOMA COPY NUMBER UP | 100 | 75 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |