Gene Page: NHEJ1
Summary ?
| GeneID | 79840 |
| Symbol | NHEJ1 |
| Synonyms | XLF |
| Description | non-homologous end joining factor 1 |
| Reference | MIM:611290|HGNC:HGNC:25737|Ensembl:ENSG00000187736|HPRD:07784|Vega:OTTHUMG00000133127 |
| Gene type | protein-coding |
| Map location | 2q35 |
| Pascal p-value | 7.874E-4 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.01016 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.00916 | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003677 | DNA binding | IEA | - | |
| GO:0042802 | identical protein binding | IPI | 16439205 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007417 | central nervous system development | NAS | Brain (GO term level: 6) | 16439204 |
| GO:0006303 | double-strand break repair via nonhomologous end joining | IMP | 16439204 |16439205 | |
| GO:0006281 | DNA repair | IEA | - | |
| GO:0010212 | response to ionizing radiation | IDA | 16439205 | |
| GO:0051351 | positive regulation of ligase activity | NAS | 16439205 | |
| GO:0030217 | T cell differentiation | IMP | 16439204 | |
| GO:0030183 | B cell differentiation | IMP | 16439204 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IDA | 16439204 |16439205 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NON HOMOLOGOUS END JOINING | 14 | 8 | All SZGR 2.0 genes in this pathway |
| PID DNA PK PATHWAY | 16 | 10 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| XU GH1 EXOGENOUS TARGETS UP | 85 | 50 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| WOO LIVER CANCER RECURRENCE DN | 80 | 54 | All SZGR 2.0 genes in this pathway |
| KASLER HDAC7 TARGETS 1 UP | 194 | 133 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| KRIEG KDM3A TARGETS NOT HYPOXIA | 208 | 107 | All SZGR 2.0 genes in this pathway |