Gene Page: NUP85

Summary ?
GeneID79902
SymbolNUP85
SynonymsFROUNT|Nup75
Descriptionnucleoporin 85kDa
ReferenceMIM:170285|HGNC:HGNC:8734|Ensembl:ENSG00000125450|HPRD:01363|Vega:OTTHUMG00000179482
Gene typeprotein-coding
Map location17q25.1
Pascal p-value0.06
Fetal beta0.962
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg151658641773201778NUP855.09E-8-0.0231.35E-5DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407NUP85799020trans
rs16955618chr1529937543NUP85799020trans
rs611133461773198827NUP85ENSG00000125450.61.515E-60.03-2927gtex_brain_ba24
rs739958001773191266NUP85ENSG00000125450.61.474E-70-10488gtex_brain_putamen_basal
rs739958011773191268NUP85ENSG00000125450.61.474E-70-10486gtex_brain_putamen_basal
rs108527591773192415NUP85ENSG00000125450.61.355E-80-9339gtex_brain_putamen_basal
rs72187181773192778NUP85ENSG00000125450.61.47E-70-8976gtex_brain_putamen_basal
rs80659961773194987NUP85ENSG00000125450.67.424E-80-6767gtex_brain_putamen_basal
rs110777791773196329NUP85ENSG00000125450.61.178E-60-5425gtex_brain_putamen_basal
rs42389791773197687NUP85ENSG00000125450.67.808E-80-4067gtex_brain_putamen_basal
rs118698801773198131NUP85ENSG00000125450.61.298E-70-3623gtex_brain_putamen_basal
rs611133461773198827NUP85ENSG00000125450.61.058E-90-2927gtex_brain_putamen_basal
rs129385751773203788NUP85ENSG00000125450.64.826E-902034gtex_brain_putamen_basal
rs116571061773204137NUP85ENSG00000125450.63.793E-902383gtex_brain_putamen_basal
rs8993261773204530NUP85ENSG00000125450.63.793E-902776gtex_brain_putamen_basal
rs129464791773208182NUP85ENSG00000125450.62.751E-706428gtex_brain_putamen_basal
rs121506161773208501NUP85ENSG00000125450.67.808E-806747gtex_brain_putamen_basal
rs72228491773212449NUP85ENSG00000125450.61.716E-8010695gtex_brain_putamen_basal
rs5456448581773218136NUP85ENSG00000125450.61.894E-7016382gtex_brain_putamen_basal
rs47891511773219644NUP85ENSG00000125450.66.766E-9017890gtex_brain_putamen_basal
rs18712691773220999NUP85ENSG00000125450.63.793E-9019245gtex_brain_putamen_basal
rs14787851773222865NUP85ENSG00000125450.61.195E-7021111gtex_brain_putamen_basal
rs2021285111773226458NUP85ENSG00000125450.62.044E-6024704gtex_brain_putamen_basal
rs99881773230856NUP85ENSG00000125450.61.863E-6029102gtex_brain_putamen_basal
rs110777811773236605NUP85ENSG00000125450.61.863E-6034851gtex_brain_putamen_basal
rs23062161773240559NUP85ENSG00000125450.61.854E-6038805gtex_brain_putamen_basal
rs22422291773242501NUP85ENSG00000125450.61.863E-6040747gtex_brain_putamen_basal
rs47891571773243307NUP85ENSG00000125450.65.76E-7041553gtex_brain_putamen_basal
rs47891581773243334NUP85ENSG00000125450.62.345E-6041580gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA AKAPCENTROSOME PATHWAY 1514All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF NON CODING RNA 4929All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 6645All SZGR 2.0 genes in this pathway
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 14077All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 5434All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING 16186All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 3321All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241157All SZGR 2.0 genes in this pathway
REACTOME GLUCOSE TRANSPORT 3829All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 17298All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159116All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192110All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247154All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE 20372All SZGR 2.0 genes in this pathway
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY 2719All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS 2719All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE 12569All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE 10461All SZGR 2.0 genes in this pathway
REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 3321All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 2719All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE 8751All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181101All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN 8749All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP 181108All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203135All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP 212128All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185116All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277166All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS DN 8950All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277172All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway