Summary ?
DescriptionCDK5 regulatory subunit associated protein 3
Gene typeprotein-coding
Map location17q21.32
Pascal p-value0.23
Sherlock p-value0.345
Fetal beta1.489
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Cerebellar Hemisphere
Frontal Cortex BA9
Putamen basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0042808neuronal Cdc2-like kinase bindingNASneuron (GO term level: 7)10721722 
GO:0005515protein bindingIPI17043677 |17353931 |17785205 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentNASBrain (GO term level: 7)10915792 
GO:0045664regulation of neuron differentiationNASneuron, neurogenesis (GO term level: 9)10721722 
GO:0000079regulation of cyclin-dependent protein kinase activityISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARL1ARFL1ADP-ribosylation factor-like 1Affinity Capture-MSBioGRID17353931 
CDK5R1CDK5P35 | CDK5R | MGC33831 | NCK5A | p23 | p25 | p35 | p35nck5acyclin-dependent kinase 5, regulatory subunit 1 (p35)-HPRD10721722 |10915792 
CDK5R1CDK5P35 | CDK5R | MGC33831 | NCK5A | p23 | p25 | p35 | p35nck5acyclin-dependent kinase 5, regulatory subunit 1 (p35)-HPRD,BioGRID11882646 
CRMP1DPYSL1 | DRP-1 | DRP1collapsin response mediator protein 1Two-hybridBioGRID16169070 
DDRGK1C20orf116 | MGC2592 | dJ1187M17.3DDRGK domain containing 1Affinity Capture-MSBioGRID17353931 
IGHA1FLJ14473 | FLJ35065 | FLJ35500 | FLJ36402 | FLJ39698 | FLJ40001 | FLJ41548 | FLJ41552 | FLJ41789 | FLJ43248 | FLJ43594 | FLJ44293 | FLJ46028 | FLJ46621 | FLJ46724 | FLJ46811 | FLJ46824 | IgA1 | MGC102857immunoglobulin heavy constant alpha 1Affinity Capture-MSBioGRID17353931 
IGKCHCAK1 | Km | MGC111575 | MGC62011 | MGC72072 | MGC88770 | MGC88771 | MGC88809immunoglobulin kappa constantAffinity Capture-MSBioGRID17353931 
KHK-ketohexokinase (fructokinase)Affinity Capture-MSBioGRID17353931 
KIAA0776RP3-393D12.1KIAA0776Affinity Capture-MSBioGRID17353931 
SMNDC1SMNR | SPF30survival motor neuron domain containing 1Affinity Capture-MSBioGRID17353931 
UFC1HSPC155ubiquitin-fold modifier conjugating enzyme 1Affinity Capture-MSBioGRID17353931 
UFM1BM-002 | C13orf20 | bA131P10.1ubiquitin-fold modifier 1Affinity Capture-MSBioGRID17353931 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED DN 8647All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269146All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344180All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 14593All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway