Gene Page: SP6
Summary ?
| GeneID | 80320 |
| Symbol | SP6 |
| Synonyms | EPFN|EPIPROFIN|KLF14 |
| Description | Sp6 transcription factor |
| Reference | MIM:608613|HGNC:HGNC:14530|Ensembl:ENSG00000189120|HPRD:12269|Vega:OTTHUMG00000132067 |
| Gene type | protein-coding |
| Map location | 17q21.32 |
| Pascal p-value | 0.197 |
| Fetal beta | 0.237 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg16779251 | 17 | 45928077 | SP6 | 4.295E-4 | -0.319 | 0.045 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17799628 | chr9 | 106442995 | SP6 | 80320 | 0.16 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RAB3B | 0.63 | 0.59 |
| ORAI2 | 0.62 | 0.60 |
| C11orf90 | 0.62 | 0.61 |
| RNF220 | 0.62 | 0.59 |
| CACNA2D3 | 0.61 | 0.57 |
| APBA1 | 0.61 | 0.63 |
| CDR2 | 0.61 | 0.60 |
| OTUB2 | 0.61 | 0.54 |
| C3orf18 | 0.60 | 0.64 |
| RPS6KA1 | 0.60 | 0.58 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.39 | -0.38 |
| AF347015.18 | -0.35 | -0.34 |
| AF347015.31 | -0.35 | -0.34 |
| AL139819.3 | -0.34 | -0.41 |
| AF347015.8 | -0.34 | -0.33 |
| MT-ATP8 | -0.34 | -0.35 |
| GNG11 | -0.34 | -0.38 |
| AF347015.27 | -0.33 | -0.33 |
| MT-CO2 | -0.33 | -0.32 |
| AF347015.2 | -0.33 | -0.27 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP | 612 | 367 | All SZGR 2.0 genes in this pathway |
| MARTORIATI MDM4 TARGETS FETAL LIVER UP | 227 | 137 | All SZGR 2.0 genes in this pathway |
| MANTOVANI VIRAL GPCR SIGNALING UP | 86 | 54 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 6HR DN | 514 | 330 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR UP | 487 | 286 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF LCP WITH H3K27ME3 | 70 | 35 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |