Gene Page: PABPC1L
Summary ?
| GeneID | 80336 |
| Symbol | PABPC1L |
| Synonyms | C20orf119|EPAB|PABPC1L1|dJ1069P2.3 |
| Description | poly(A) binding protein, cytoplasmic 1-like |
| Reference | HGNC:HGNC:15797|Ensembl:ENSG00000101104|Vega:OTTHUMG00000032553 |
| Gene type | protein-coding |
| Map location | - |
| Pascal p-value | 4.658E-4 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6017437 | 20 | 43503276 | PABPC1L | ENSG00000101104.8 | 1.887E-6 | 0 | -35427 | gtex_brain_ba24 |
| rs6031847 | 20 | 43514203 | PABPC1L | ENSG00000101104.8 | 3.453E-10 | 0 | -24500 | gtex_brain_ba24 |
| rs6031848 | 20 | 43514210 | PABPC1L | ENSG00000101104.8 | 3.395E-10 | 0 | -24493 | gtex_brain_ba24 |
| rs6031849 | 20 | 43514337 | PABPC1L | ENSG00000101104.8 | 3.676E-10 | 0 | -24366 | gtex_brain_ba24 |
| rs7265519 | 20 | 43515270 | PABPC1L | ENSG00000101104.8 | 7.317E-10 | 0 | -23433 | gtex_brain_ba24 |
| rs2239535 | 20 | 43516156 | PABPC1L | ENSG00000101104.8 | 4.436E-7 | 0 | -22547 | gtex_brain_ba24 |
| rs2284265 | 20 | 43517041 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -21662 | gtex_brain_ba24 |
| rs2284266 | 20 | 43517201 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -21502 | gtex_brain_ba24 |
| rs6031851 | 20 | 43519537 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -19166 | gtex_brain_ba24 |
| rs200037216 | 20 | 43520287 | PABPC1L | ENSG00000101104.8 | 2.269E-10 | 0 | -18416 | gtex_brain_ba24 |
| rs10582089 | 20 | 43520290 | PABPC1L | ENSG00000101104.8 | 2.146E-10 | 0 | -18413 | gtex_brain_ba24 |
| rs6031853 | 20 | 43522174 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -16529 | gtex_brain_ba24 |
| rs16989474 | 20 | 43522725 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -15978 | gtex_brain_ba24 |
| rs6031855 | 20 | 43522834 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -15869 | gtex_brain_ba24 |
| rs2267848 | 20 | 43524205 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -14498 | gtex_brain_ba24 |
| rs2267850 | 20 | 43524963 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -13740 | gtex_brain_ba24 |
| rs6017442 | 20 | 43527337 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -11366 | gtex_brain_ba24 |
| rs6017443 | 20 | 43528209 | PABPC1L | ENSG00000101104.8 | 2.167E-10 | 0 | -10494 | gtex_brain_ba24 |
| rs6017444 | 20 | 43528521 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -10182 | gtex_brain_ba24 |
| rs6031858 | 20 | 43528962 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -9741 | gtex_brain_ba24 |
| rs6031859 | 20 | 43529679 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -9024 | gtex_brain_ba24 |
| rs4931 | 20 | 43530234 | PABPC1L | ENSG00000101104.8 | 2.163E-10 | 0 | -8469 | gtex_brain_ba24 |
| rs6031860 | 20 | 43532388 | PABPC1L | ENSG00000101104.8 | 5.753E-10 | 0 | -6315 | gtex_brain_ba24 |
| rs12481468 | 20 | 43532438 | PABPC1L | ENSG00000101104.8 | 5.753E-10 | 0 | -6265 | gtex_brain_ba24 |
| rs3761188 | 20 | 43533286 | PABPC1L | ENSG00000101104.8 | 2.164E-10 | 0 | -5417 | gtex_brain_ba24 |
| rs16989481 | 20 | 43534903 | PABPC1L | ENSG00000101104.8 | 2.166E-10 | 0 | -3800 | gtex_brain_ba24 |
| rs8356 | 20 | 43536455 | PABPC1L | ENSG00000101104.8 | 6.022E-10 | 0 | -2248 | gtex_brain_ba24 |
| rs60995368 | 20 | 43536817 | PABPC1L | ENSG00000101104.8 | 2.196E-8 | 0 | -1886 | gtex_brain_ba24 |
| rs16989483 | 20 | 43537200 | PABPC1L | ENSG00000101104.8 | 2.322E-10 | 0 | -1503 | gtex_brain_ba24 |
| rs2072726 | 20 | 43538597 | PABPC1L | ENSG00000101104.8 | 2.507E-10 | 0 | -106 | gtex_brain_ba24 |
| rs6031867 | 20 | 43540321 | PABPC1L | ENSG00000101104.8 | 1.731E-7 | 0 | 1618 | gtex_brain_ba24 |
| rs2235172 | 20 | 43541183 | PABPC1L | ENSG00000101104.8 | 5.859E-8 | 0 | 2480 | gtex_brain_ba24 |
| rs16989485 | 20 | 43542667 | PABPC1L | ENSG00000101104.8 | 5.843E-8 | 0 | 3964 | gtex_brain_ba24 |
| rs6130713 | 20 | 43543582 | PABPC1L | ENSG00000101104.8 | 2.38E-8 | 0 | 4879 | gtex_brain_ba24 |
| rs3092074 | 20 | 43544528 | PABPC1L | ENSG00000101104.8 | 8.646E-7 | 0 | 5825 | gtex_brain_ba24 |
| rs2425679 | 20 | 43546427 | PABPC1L | ENSG00000101104.8 | 8.257E-7 | 0 | 7724 | gtex_brain_ba24 |
| rs2425681 | 20 | 43546862 | PABPC1L | ENSG00000101104.8 | 8.257E-7 | 0 | 8159 | gtex_brain_ba24 |
| rs2425682 | 20 | 43546954 | PABPC1L | ENSG00000101104.8 | 8.257E-7 | 0 | 8251 | gtex_brain_ba24 |
| rs2072728 | 20 | 43547537 | PABPC1L | ENSG00000101104.8 | 8.123E-7 | 0 | 8834 | gtex_brain_ba24 |
| rs2280983 | 20 | 43548418 | PABPC1L | ENSG00000101104.8 | 8.257E-7 | 0 | 9715 | gtex_brain_ba24 |
| rs2072729 | 20 | 43548431 | PABPC1L | ENSG00000101104.8 | 8.257E-7 | 0 | 9728 | gtex_brain_ba24 |
| rs2425683 | 20 | 43548642 | PABPC1L | ENSG00000101104.8 | 8.36E-7 | 0 | 9939 | gtex_brain_ba24 |
| rs3092334 | 20 | 43548680 | PABPC1L | ENSG00000101104.8 | 8.435E-7 | 0 | 9977 | gtex_brain_ba24 |
| rs2425684 | 20 | 43548739 | PABPC1L | ENSG00000101104.8 | 8.426E-7 | 0 | 10036 | gtex_brain_ba24 |
| rs2425685 | 20 | 43549853 | PABPC1L | ENSG00000101104.8 | 9.503E-7 | 0 | 11150 | gtex_brain_ba24 |
| rs2425686 | 20 | 43550045 | PABPC1L | ENSG00000101104.8 | 9.346E-7 | 0 | 11342 | gtex_brain_ba24 |
| rs2425687 | 20 | 43551278 | PABPC1L | ENSG00000101104.8 | 1.638E-6 | 0 | 12575 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN | 74 | 42 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY UP | 430 | 232 | All SZGR 2.0 genes in this pathway |
| KUNINGER IGF1 VS PDGFB TARGETS UP | 82 | 51 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
| MASSARWEH TAMOXIFEN RESISTANCE DN | 258 | 160 | All SZGR 2.0 genes in this pathway |
| MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN | 229 | 135 | All SZGR 2.0 genes in this pathway |