Summary ?
GeneID80351
SymbolTNKS2
SynonymsARTD6|PARP-5b|PARP-5c|PARP5B|PARP5C|TANK2|TNKL|pART6
Descriptiontankyrase 2
ReferenceMIM:607128|HGNC:HGNC:15677|Ensembl:ENSG00000107854|HPRD:06182|Vega:OTTHUMG00000018747
Gene typeprotein-coding
Map location10q23.3
Pascal p-value0.061
Fetal beta0.427
DMG1 (# studies)
eGeneCerebellum
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg199127361093567154TNKS21.638E-40.4240.033DMG:Wockner_2014
cg119634361093567261TNKS24.123E-40.6630.044DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1570589chr9116874354TNKS2803510.19trans
rs10994209chr1061877705TNKS2803510.17trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TRPV20.700.47
CR392039.30.690.23
AC130364.20.690.46
SIRPB10.690.26
HISPPD2A0.650.55
PTPRN0.640.59
SRPR0.640.61
AC134878.10.630.13
KCNJ90.630.46
CLSTN30.630.64
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FAM36A-0.29-0.16
C21orf57-0.27-0.25
GTF3C6-0.25-0.21
BCL7C-0.25-0.33
IMPA2-0.23-0.38
SNHG12-0.23-0.29
AC090186.1-0.23-0.18
RPL31-0.23-0.26
RPL35-0.23-0.27
RPS20-0.22-0.28

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS UP 9457All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165106All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 12778All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN 186114All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
BOUDOUKHA BOUND BY IGF2BP2 11159All SZGR 2.0 genes in this pathway