Gene Page: CALM2

Summary ?
GeneID805
SymbolCALM2
SynonymsCAMII|LQT15|PHKD|PHKD2|caM
Descriptioncalmodulin 2 (phosphorylase kinase, delta)
ReferenceMIM:114182|HGNC:HGNC:1445|Ensembl:ENSG00000143933|HPRD:00242|Vega:OTTHUMG00000128850
Gene typeprotein-coding
Map location2p21
Pascal p-value0.008
Sherlock p-value0.798
SupportINTRACELLULAR SIGNAL TRANSDUCTION
SEROTONIN

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP9AKAP350 | AKAP450 | CG-NAP | HYPERION | KIAA0803 | MU-RMS-40.16A | PRKA9 | YOTIAOA kinase (PRKA) anchor protein (yotiao) 9Two-hybridBioGRID12221128 
ASCL2ASH2 | HASH2 | MASH2 | bHLHa45achaete-scute complex homolog 2 (Drosophila)-HPRD10757985 
CALD1CDM | H-CAD | L-CAD | MGC21352 | NAG22caldesmon 1-HPRD11736632 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD11981030 
ESR2ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2estrogen receptor 2 (ER beta)-HPRD11981030 
GRM5GPRC1E | MGLUR5 | MGLUR5A | MGLUR5B | mGlu5glutamate receptor, metabotropic 5-HPRD9242710 |11953448 
GRM7FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7glutamate receptor, metabotropic 7-HPRD11953448 
INVSINV | KIAA0573 | MGC133080 | MGC133081 | NPH2 | NPHP2inversinAn unspecified isoform of INVS interacts with CALM2.BIND15723066 
IQCB1NPHP5 | PIQ | SLSN5IQ motif containing B1IQCB1 interacts with CALM2.BIND15723066 
KCNQ2BFNC | EBN | EBN1 | ENB1 | HNSPC | KCNA11 | KV7.2 | KVEBN1potassium voltage-gated channel, KQT-like subfamily, member 2-HPRD,BioGRID12032157 
KCNQ5Kv7.5potassium voltage-gated channel, KQT-like subfamily, member 5-HPRD12032157 
KIAA1683MGC131731KIAA1683Two-hybridBioGRID16189514 
MARCKS80K-L | FLJ14368 | FLJ90045 | MACS | MRACKS | PKCSL | PRKCSLmyristoylated alanine-rich protein kinase C substrate-HPRD,BioGRID12577052 
MRPL20L20mt | MGC4779 | MGC74465 | MRP-L20mitochondrial ribosomal protein L20Two-hybridBioGRID16169070 
MYF5bHLHc2myogenic factor 5-HPRD10757985 
MYF6MRF4 | bHLHc4myogenic factor 6 (herculin)-HPRD10757985 
MYO6DFNA22 | DFNB37 | KIAA0389myosin VITwo-hybridBioGRID16169070 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD10757985 
MYOGMYF4 | MYOGENIN | bHLHc3myogenin (myogenic factor 4)-HPRD10757985 
NEUROD1BETA2 | BHF-1 | NEUROD | bHLHa3neurogenic differentiation 1-HPRD10757985 
PCNTKEN | MOPD2 | PCN | PCNT2 | PCNTB | PCTN2 | SCKL4pericentrin-HPRD10823944 |12221128 
PPEF1PP7 | PPEF | PPP7Cprotein phosphatase, EF-hand calcium binding domain 1-HPRD12051765 
PPEF2-protein phosphatase, EF-hand calcium binding domain 2-HPRD12051765 
RAB3B-RAB3B, member RAS oncogene family-HPRD11741295 
TCF4E2-2 | ITF2 | MGC149723 | MGC149724 | PTHS | SEF2 | SEF2-1 | SEF2-1A | SEF2-1B | bHLHb19transcription factor 4-HPRD10757985 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 7656All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 11479All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 11581All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 7057All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126103All SZGR 2.0 genes in this pathway
KEGG OLFACTORY TRANSDUCTION 38985All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137103All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 10177All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 10280All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169110All SZGR 2.0 genes in this pathway
KEGG GLIOMA 6556All SZGR 2.0 genes in this pathway
BIOCARTA NO1 PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY 3628All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY 3728All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY 4535All SZGR 2.0 genes in this pathway
BIOCARTA CACAM PATHWAY 1611All SZGR 2.0 genes in this pathway
BIOCARTA HDAC PATHWAY 3225All SZGR 2.0 genes in this pathway
BIOCARTA GCR PATHWAY 2217All SZGR 2.0 genes in this pathway
BIOCARTA CALCINEURIN PATHWAY 2117All SZGR 2.0 genes in this pathway
BIOCARTA NDKDYNAMIN PATHWAY 2115All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY 4130All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY 3929All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY 3124All SZGR 2.0 genes in this pathway
BIOCARTA VIP PATHWAY 2926All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 5645All SZGR 2.0 genes in this pathway
BIOCARTA NOS1 PATHWAY 2421All SZGR 2.0 genes in this pathway
BIOCARTA CCR5 PATHWAY 2016All SZGR 2.0 genes in this pathway
BIOCARTA PGC1A PATHWAY 2620All SZGR 2.0 genes in this pathway
BIOCARTA MEF2D PATHWAY 2316All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY 3731All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY 4937All SZGR 2.0 genes in this pathway
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 1810All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING 3225All SZGR 2.0 genes in this pathway
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 139All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 10178All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 10980All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS 2924All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 12690All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 12788All SZGR 2.0 genes in this pathway
REACTOME ENOS ACTIVATION AND REGULATION 2014All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 8956All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 7856All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS 3023All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS 2520All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS 4332All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 12293All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 9576All SZGR 2.0 genes in this pathway
REACTOME MUSCLE CONTRACTION 4824All SZGR 2.0 genes in this pathway
REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR 1715All SZGR 2.0 genes in this pathway
REACTOME SMOOTH MUSCLE CONTRACTION 2514All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 3732All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 2723All SZGR 2.0 genes in this pathway
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS 3328All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 1514All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 10074All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 5440All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 3123All SZGR 2.0 genes in this pathway
REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 1111All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247154All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME GLUCOSE METABOLISM 6942All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 11280All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 15093All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER DN 5945All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165107All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180110All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181107All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206136All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE UP 8649All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN 9055All SZGR 2.0 genes in this pathway
MORI PLASMA CELL DN 3320All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151103All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP 8152All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP 7149All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT DN 1917All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163113All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX DN 5443All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261166All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS 6945All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN 7945All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175103All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN 14279All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277172All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 16286All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL 12985All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway