Gene Page: CUL5

Summary
GeneID  8065
Symbol  CUL5
Synonyms  VACM-1|VACM1
Description  cullin 5
See related  HGNC:2556|MIM:601741|Ensembl:ENSG00000166266|HPRD:03444|
Locus tag  -
Gene type  protein-coding
Map location  11q22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0125 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS9581826 
GO:0005515protein bindingIPI12504025 
GO:0005262calcium channel activityTAS9581826 
GO:0031625ubiquitin protein ligase bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000082G1/S transition of mitotic cell cycleTAS8681378 
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0007050cell cycle arrestTAS8681378 
GO:0008285negative regulation of cell proliferationTAS8681378 
GO:0008629induction of apoptosis by intracellular signalsTAS9581826 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA18029348 
GO:0005829cytosolEXP14564014 |15781449 
GO:0005737cytoplasmIDA18029348 
GO:0031461cullin-RING ubiquitin ligase complexIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASB3ASB-3 | FLJ10123 | FLJ10421 | MGC12531 | MGC132002 | MGC996ankyrin repeat and SOCS box-containing 3Affinity Capture-MSBioGRID17353931 
RBX1BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1ring-box 1Rbx1 interacts with Cul5.BIND14564014 
RNF7CKBBP1 | ROC2 | SAGring finger protein 7-HPRD,BioGRID10230407 
TCEB1SIIItranscription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)Reconstituted ComplexBioGRID11384984 
TCEB2ELOB | SIIItranscription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)Reconstituted ComplexBioGRID11384984 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorReconstituted ComplexBioGRID11384984 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G 5230All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_WITH_LOH_IN_CHR9Q 11671All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC 10874All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
GEORGES_CELL_CYCLE_MIR192_TARGETS 6246All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_DN 8056All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR 14984All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
NIELSEN_GIST 9866All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1120126m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5061201261Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-148/1523934001A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-18132123218m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-182112311301A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-186225522611Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-191891951Ahsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-217327732841A,m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-299-5p192319291Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-31112211281Ahsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-324-5p30563062m8hsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-33202320291Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-3706436491Ahsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-381333533411Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-410114811541Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-433-3p2342401Ahsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
miR-493-5p11341140m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-96112411301Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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