Summary ?
GeneID80705
SymbolTSGA10
SynonymsCEP4L|CT79
Descriptiontestis specific 10
ReferenceMIM:607166|HGNC:HGNC:14927|Ensembl:ENSG00000135951|HPRD:06202|Vega:OTTHUMG00000130637
Gene typeprotein-coding
Map location2q11.2
Pascal p-value0.958
Fetal beta-1.24
eGeneAnterior cingulate cortex BA24
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hypothalamus
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.0004 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16869851chr420690056TSGA10807050.18trans
rs62158260299560872TSGA10ENSG00000135951.104.8E-70.01210227gtex_brain_ba24
rs11123761299705903TSGA10ENSG00000135951.105.851E-70.0165196gtex_brain_ba24
rs11678456299708237TSGA10ENSG00000135951.105.688E-70.0162862gtex_brain_ba24
rs13035311299717322TSGA10ENSG00000135951.105.851E-70.0153777gtex_brain_ba24
rs4402818299717608TSGA10ENSG00000135951.105.851E-70.0153491gtex_brain_ba24
rs34766932299737273TSGA10ENSG00000135951.105.851E-70.0133826gtex_brain_ba24
rs35416081299738089TSGA10ENSG00000135951.105.638E-70.0133010gtex_brain_ba24
rs72545190299744175TSGA10ENSG00000135951.102.967E-70.0126924gtex_brain_ba24
rs4851188299745898TSGA10ENSG00000135951.102.534E-60.0125201gtex_brain_ba24
rs11123764299750677TSGA10ENSG00000135951.105.851E-70.0120422gtex_brain_ba24
rs13035357299752246TSGA10ENSG00000135951.102.981E-60.0118853gtex_brain_ba24
rs9941561299753829TSGA10ENSG00000135951.105.856E-70.0117270gtex_brain_ba24
rs13010904299754289TSGA10ENSG00000135951.102.408E-60.0116810gtex_brain_ba24
rs13012481299754290TSGA10ENSG00000135951.102.408E-60.0116809gtex_brain_ba24
rs6717729299756941TSGA10ENSG00000135951.105.851E-70.0114158gtex_brain_ba24
rs541314634299760481TSGA10ENSG00000135951.101.926E-60.0110618gtex_brain_ba24
rs12995473299764884TSGA10ENSG00000135951.105.851E-70.016215gtex_brain_ba24
rs11685756299766215TSGA10ENSG00000135951.105.851E-70.014884gtex_brain_ba24
rs11684610299766322TSGA10ENSG00000135951.102.283E-60.014777gtex_brain_ba24
rs2632261299771272TSGA10ENSG00000135951.105.851E-70.01-173gtex_brain_ba24
rs2516828299772875TSGA10ENSG00000135951.105.851E-70.01-1776gtex_brain_ba24
rs2516829299773201TSGA10ENSG00000135951.105.851E-70.01-2102gtex_brain_ba24
rs2516833299777405TSGA10ENSG00000135951.102.849E-60.01-6306gtex_brain_ba24
rs6542869299783403TSGA10ENSG00000135951.105.851E-70.01-12304gtex_brain_ba24
rs6708576299801308TSGA10ENSG00000135951.105.851E-70.01-30209gtex_brain_ba24
rs11677321299810482TSGA10ENSG00000135951.102.417E-60.01-39383gtex_brain_ba24
rs1044575299812070TSGA10ENSG00000135951.105.851E-70.01-40971gtex_brain_ba24
rs11674894299818972TSGA10ENSG00000135951.108.124E-70.01-47873gtex_brain_ba24
rs11123770299825102TSGA10ENSG00000135951.102.282E-70.01-54003gtex_brain_ba24
rs12477438299841085TSGA10ENSG00000135951.101.343E-60.01-69986gtex_brain_ba24
rs13031919299848932TSGA10ENSG00000135951.102.001E-70.01-77833gtex_brain_ba24
rs12991189299854284TSGA10ENSG00000135951.103.601E-70.01-83185gtex_brain_ba24
rs4851196299858556TSGA10ENSG00000135951.101.221E-60.01-87457gtex_brain_ba24
rs17760953299859863TSGA10ENSG00000135951.101.577E-60.01-88764gtex_brain_ba24
rs12999417299865548TSGA10ENSG00000135951.101.318E-60.01-94449gtex_brain_ba24
rs720229299704273TSGA10ENSG00000135951.107.915E-7066826gtex_brain_putamen_basal
rs720228299704547TSGA10ENSG00000135951.102.877E-6066552gtex_brain_putamen_basal
rs11123761299705903TSGA10ENSG00000135951.103.41E-7065196gtex_brain_putamen_basal
rs6753650299706817TSGA10ENSG00000135951.101.008E-6064282gtex_brain_putamen_basal
rs12619780299707307TSGA10ENSG00000135951.101.272E-6063792gtex_brain_putamen_basal
rs11678456299708237TSGA10ENSG00000135951.104.533E-7062862gtex_brain_putamen_basal
rs11695751299708247TSGA10ENSG00000135951.103.712E-6062852gtex_brain_putamen_basal
rs11900670299709415TSGA10ENSG00000135951.103.075E-6061684gtex_brain_putamen_basal
rs397985274299710009TSGA10ENSG00000135951.101.231E-6061090gtex_brain_putamen_basal
rs12987548299712292TSGA10ENSG00000135951.103.801E-7058807gtex_brain_putamen_basal
rs57733877299715077TSGA10ENSG00000135951.102.76E-6056022gtex_brain_putamen_basal
rs13020339299715664TSGA10ENSG00000135951.103.889E-6055435gtex_brain_putamen_basal
rs13035311299717322TSGA10ENSG00000135951.103.41E-7053777gtex_brain_putamen_basal
rs4402818299717608TSGA10ENSG00000135951.103.41E-7053491gtex_brain_putamen_basal
rs10865029299718298TSGA10ENSG00000135951.103.075E-6052801gtex_brain_putamen_basal
rs6712704299719687TSGA10ENSG00000135951.103.075E-6051412gtex_brain_putamen_basal
rs1453563299720267TSGA10ENSG00000135951.101.545E-7050832gtex_brain_putamen_basal
rs11683188299724512TSGA10ENSG00000135951.101.552E-7046587gtex_brain_putamen_basal
rs4340581299725025TSGA10ENSG00000135951.102.884E-6046074gtex_brain_putamen_basal
rs6542863299725138TSGA10ENSG00000135951.103.075E-6045961gtex_brain_putamen_basal
rs6542864299725223TSGA10ENSG00000135951.103.075E-6045876gtex_brain_putamen_basal
rs6733285299725575TSGA10ENSG00000135951.104.84E-7045524gtex_brain_putamen_basal
rs11123762299727789TSGA10ENSG00000135951.103.075E-6043310gtex_brain_putamen_basal
rs7577477299728293TSGA10ENSG00000135951.103.075E-6042806gtex_brain_putamen_basal
rs11354035299729007TSGA10ENSG00000135951.101.552E-7042092gtex_brain_putamen_basal
rs7584809299730199TSGA10ENSG00000135951.102.422E-6040900gtex_brain_putamen_basal
rs11692699299730657TSGA10ENSG00000135951.103.075E-6040442gtex_brain_putamen_basal
rs13022329299731189TSGA10ENSG00000135951.103.075E-6039910gtex_brain_putamen_basal
rs6739579299731552TSGA10ENSG00000135951.103.075E-6039547gtex_brain_putamen_basal
rs6743355299732360TSGA10ENSG00000135951.103.075E-6038739gtex_brain_putamen_basal
rs12613624299732741TSGA10ENSG00000135951.101.552E-7038358gtex_brain_putamen_basal
rs11688004299735052TSGA10ENSG00000135951.106.939E-7036047gtex_brain_putamen_basal
rs17759607299737005TSGA10ENSG00000135951.106.939E-7034094gtex_brain_putamen_basal
rs36071868299737120TSGA10ENSG00000135951.102.884E-6033979gtex_brain_putamen_basal
rs34766932299737273TSGA10ENSG00000135951.103.41E-7033826gtex_brain_putamen_basal
rs34272114299737443TSGA10ENSG00000135951.101.552E-7033656gtex_brain_putamen_basal
rs34252185299737646TSGA10ENSG00000135951.102.884E-6033453gtex_brain_putamen_basal
rs35416081299738089TSGA10ENSG00000135951.101.235E-6033010gtex_brain_putamen_basal
rs13023744299738224TSGA10ENSG00000135951.102.884E-6032875gtex_brain_putamen_basal
rs6741772299738961TSGA10ENSG00000135951.106.183E-7032138gtex_brain_putamen_basal
rs6741773299738962TSGA10ENSG00000135951.106.183E-7032137gtex_brain_putamen_basal
rs6751927299740175TSGA10ENSG00000135951.102.884E-6030924gtex_brain_putamen_basal
rs11692336299740606TSGA10ENSG00000135951.101.552E-7030493gtex_brain_putamen_basal
rs1133978299741964TSGA10ENSG00000135951.101.554E-7029135gtex_brain_putamen_basal
rs1133977299741984TSGA10ENSG00000135951.106.939E-7029115gtex_brain_putamen_basal
rs11695379299742161TSGA10ENSG00000135951.103.075E-6028938gtex_brain_putamen_basal
rs13008171299743419TSGA10ENSG00000135951.101.552E-7027680gtex_brain_putamen_basal
rs4851187299745860TSGA10ENSG00000135951.102.884E-6025239gtex_brain_putamen_basal
rs4851188299745898TSGA10ENSG00000135951.106.939E-7025201gtex_brain_putamen_basal
rs11895749299746290TSGA10ENSG00000135951.106.939E-7024809gtex_brain_putamen_basal
rs78142075299747410TSGA10ENSG00000135951.101.933E-6023689gtex_brain_putamen_basal
rs7604557299747829TSGA10ENSG00000135951.102.884E-6023270gtex_brain_putamen_basal
rs138043385299749154TSGA10ENSG00000135951.102.077E-6021945gtex_brain_putamen_basal
rs4588238299749350TSGA10ENSG00000135951.103.075E-6021749gtex_brain_putamen_basal
rs11692669299750346TSGA10ENSG00000135951.103.701E-7020753gtex_brain_putamen_basal
rs11123763299750673TSGA10ENSG00000135951.103.075E-6020426gtex_brain_putamen_basal
rs11123764299750677TSGA10ENSG00000135951.103.41E-7020422gtex_brain_putamen_basal
rs13035357299752246TSGA10ENSG00000135951.106.801E-8018853gtex_brain_putamen_basal
rs9941561299753829TSGA10ENSG00000135951.103.41E-7017270gtex_brain_putamen_basal
rs12992218299753834TSGA10ENSG00000135951.103.076E-6017265gtex_brain_putamen_basal
rs13010904299754289TSGA10ENSG00000135951.101.741E-6016810gtex_brain_putamen_basal
rs13012481299754290TSGA10ENSG00000135951.101.741E-6016809gtex_brain_putamen_basal
rs13018891299755099TSGA10ENSG00000135951.103.075E-6016000gtex_brain_putamen_basal
rs11677247299756358TSGA10ENSG00000135951.103.075E-6014741gtex_brain_putamen_basal
rs6717723299756930TSGA10ENSG00000135951.102.884E-6014169gtex_brain_putamen_basal
rs6717729299756941TSGA10ENSG00000135951.103.41E-7014158gtex_brain_putamen_basal
rs58516622299758020TSGA10ENSG00000135951.105.923E-6013079gtex_brain_putamen_basal
rs11683107299759235TSGA10ENSG00000135951.106.939E-7011864gtex_brain_putamen_basal
rs6726618299759865TSGA10ENSG00000135951.106.199E-6011234gtex_brain_putamen_basal
rs541314634299760481TSGA10ENSG00000135951.105.781E-7010618gtex_brain_putamen_basal
rs369731360299764260TSGA10ENSG00000135951.105.183E-706839gtex_brain_putamen_basal
rs6542865299764521TSGA10ENSG00000135951.103.075E-606578gtex_brain_putamen_basal
rs6542866299764592TSGA10ENSG00000135951.106.939E-706507gtex_brain_putamen_basal
rs12995473299764884TSGA10ENSG00000135951.103.41E-706215gtex_brain_putamen_basal
rs11685756299766215TSGA10ENSG00000135951.103.41E-704884gtex_brain_putamen_basal
rs11685759299766217TSGA10ENSG00000135951.103.322E-604882gtex_brain_putamen_basal
rs11684610299766322TSGA10ENSG00000135951.101.454E-604777gtex_brain_putamen_basal
rs11890338299767868TSGA10ENSG00000135951.105.131E-603231gtex_brain_putamen_basal
rs11123765299768064TSGA10ENSG00000135951.102.884E-603035gtex_brain_putamen_basal
rs34715372299768274TSGA10ENSG00000135951.103.125E-602825gtex_brain_putamen_basal
rs4850897299768419TSGA10ENSG00000135951.101.318E-702680gtex_brain_putamen_basal
rs2516832299771268TSGA10ENSG00000135951.103.075E-60-169gtex_brain_putamen_basal
rs2632261299771272TSGA10ENSG00000135951.103.41E-70-173gtex_brain_putamen_basal
rs2516834299771533TSGA10ENSG00000135951.104.738E-60-434gtex_brain_putamen_basal
rs2632260299771590TSGA10ENSG00000135951.102.884E-60-491gtex_brain_putamen_basal
rs2516827299772565TSGA10ENSG00000135951.103.075E-60-1466gtex_brain_putamen_basal
rs2516828299772875TSGA10ENSG00000135951.103.41E-70-1776gtex_brain_putamen_basal
rs2516829299773201TSGA10ENSG00000135951.103.41E-70-2102gtex_brain_putamen_basal
rs2516830299773702TSGA10ENSG00000135951.101.552E-70-2603gtex_brain_putamen_basal
rs2632284299775865TSGA10ENSG00000135951.103.04E-60-4766gtex_brain_putamen_basal
rs2632283299776000TSGA10ENSG00000135951.101.552E-70-4901gtex_brain_putamen_basal
rs2969379299776686TSGA10ENSG00000135951.102.884E-60-5587gtex_brain_putamen_basal
rs2516833299777405TSGA10ENSG00000135951.101.581E-70-6306gtex_brain_putamen_basal
rs2632277299778985TSGA10ENSG00000135951.102.884E-60-7886gtex_brain_putamen_basal
rs2516835299779131TSGA10ENSG00000135951.101.552E-70-8032gtex_brain_putamen_basal
rs2632276299779655TSGA10ENSG00000135951.106.965E-60-8556gtex_brain_putamen_basal
rs11123766299780915TSGA10ENSG00000135951.103.075E-60-9816gtex_brain_putamen_basal
rs200881982299781004TSGA10ENSG00000135951.105.516E-60-9905gtex_brain_putamen_basal
rs60992070299781008TSGA10ENSG00000135951.105.432E-60-9909gtex_brain_putamen_basal
rs75281991299781339TSGA10ENSG00000135951.103.587E-70-10240gtex_brain_putamen_basal
rs7608938299782226TSGA10ENSG00000135951.101.552E-70-11127gtex_brain_putamen_basal
rs2964969299782811TSGA10ENSG00000135951.102.851E-60-11712gtex_brain_putamen_basal
rs6542868299782848TSGA10ENSG00000135951.101.552E-70-11749gtex_brain_putamen_basal
rs6542869299783403TSGA10ENSG00000135951.103.41E-70-12304gtex_brain_putamen_basal
rs2309581299784292TSGA10ENSG00000135951.103.075E-60-13193gtex_brain_putamen_basal
rs7572660299788582TSGA10ENSG00000135951.103.075E-60-17483gtex_brain_putamen_basal
rs12992930299791397TSGA10ENSG00000135951.103.075E-60-20298gtex_brain_putamen_basal
rs12621007299791946TSGA10ENSG00000135951.102.884E-60-20847gtex_brain_putamen_basal
rs13023479299793041TSGA10ENSG00000135951.103.683E-60-21942gtex_brain_putamen_basal
rs13023501299793070TSGA10ENSG00000135951.101.812E-70-21971gtex_brain_putamen_basal
rs6727749299793590TSGA10ENSG00000135951.101.552E-70-22491gtex_brain_putamen_basal
rs13033012299795149TSGA10ENSG00000135951.101.552E-70-24050gtex_brain_putamen_basal
rs13000731299795231TSGA10ENSG00000135951.101.552E-70-24132gtex_brain_putamen_basal
rs8179690299795300TSGA10ENSG00000135951.103.075E-60-24201gtex_brain_putamen_basal
rs2171359299795360TSGA10ENSG00000135951.103.075E-60-24261gtex_brain_putamen_basal
rs6542870299796638TSGA10ENSG00000135951.103.075E-60-25539gtex_brain_putamen_basal
rs11689265299799267TSGA10ENSG00000135951.102.884E-60-28168gtex_brain_putamen_basal
rs13030961299799520TSGA10ENSG00000135951.102.614E-60-28421gtex_brain_putamen_basal
rs397756933299799633TSGA10ENSG00000135951.101.554E-70-28534gtex_brain_putamen_basal
rs11883676299800814TSGA10ENSG00000135951.103.075E-60-29715gtex_brain_putamen_basal
rs6708576299801308TSGA10ENSG00000135951.103.41E-70-30209gtex_brain_putamen_basal
rs6753063299801469TSGA10ENSG00000135951.103.075E-60-30370gtex_brain_putamen_basal
rs6708878299801564TSGA10ENSG00000135951.102.227E-70-30465gtex_brain_putamen_basal
rs6756650299801800TSGA10ENSG00000135951.103.075E-60-30701gtex_brain_putamen_basal
rs6757661299802820TSGA10ENSG00000135951.103.068E-60-31721gtex_brain_putamen_basal
rs13009147299803998TSGA10ENSG00000135951.103.012E-60-32899gtex_brain_putamen_basal
rs4347885299804007TSGA10ENSG00000135951.101.466E-70-32908gtex_brain_putamen_basal
rs7558004299808795TSGA10ENSG00000135951.102.974E-60-37696gtex_brain_putamen_basal
rs11677321299810482TSGA10ENSG00000135951.101.404E-60-39383gtex_brain_putamen_basal
rs7605843299811894TSGA10ENSG00000135951.102.932E-60-40795gtex_brain_putamen_basal
rs1044575299812070TSGA10ENSG00000135951.103.241E-70-40971gtex_brain_putamen_basal
rs13798299813614TSGA10ENSG00000135951.101.435E-60-42515gtex_brain_putamen_basal
rs386390715299814298TSGA10ENSG00000135951.101.136E-60-43199gtex_brain_putamen_basal
rs7349217299815146TSGA10ENSG00000135951.101.404E-60-44047gtex_brain_putamen_basal
rs11674894299818972TSGA10ENSG00000135951.103.144E-70-47873gtex_brain_putamen_basal
rs11123770299825102TSGA10ENSG00000135951.101.823E-70-54003gtex_brain_putamen_basal
rs13031919299848932TSGA10ENSG00000135951.101.938E-70-77833gtex_brain_putamen_basal
rs12991189299854284TSGA10ENSG00000135951.105.465E-70-83185gtex_brain_putamen_basal
rs72129133299855022TSGA10ENSG00000135951.104.841E-60-83923gtex_brain_putamen_basal
rs12999417299865548TSGA10ENSG00000135951.102.658E-70-94449gtex_brain_putamen_basal
rs543330356299905014TSGA10ENSG00000135951.102.165E-60-133915gtex_brain_putamen_basal
rs1922624299909958TSGA10ENSG00000135951.102.165E-60-138859gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TTC39A0.850.54
RGS160.840.39
HRH30.830.55
PTPN30.830.38
NOD20.830.35
PAPPA0.830.30
GRID2IP0.820.20
MEI10.820.41
FAM19A40.810.46
PCP40.810.48
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
WDR86-0.25-0.21
PLEKHO1-0.25-0.25
RBMX2-0.23-0.42
NR2C2AP-0.23-0.26
EMX1-0.22-0.21
EMID1-0.22-0.22
ZNF435-0.22-0.27
ZNF184-0.22-0.13
MEIS3P2-0.220.06
MPPED1-0.21-0.24

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030031cell projection biogenesisIEAaxon (GO term level: 8)-
GO:0007283spermatogenesisTAS11179690 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043005neuron projectionIEAneuron, axon, neurite, dendrite (GO term level: 5)-
GO:0005575cellular_componentND-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
GO:0009434microtubule-based flagellumIEA-
GO:0031965nuclear membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KIM RESPONSE TO TSA AND DECITABINE UP 12973All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349157All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456228All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473224All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE DN 8842All SZGR 2.0 genes in this pathway
CONRAD GERMLINE STEM CELL 138All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway