Gene Page: ACTN4

Summary ?
GeneID81
SymbolACTN4
SynonymsACTININ-4|FSGS|FSGS1
Descriptionactinin alpha 4
ReferenceMIM:604638|HGNC:HGNC:166|HPRD:05222|
Gene typeprotein-coding
Map location19q13
Pascal p-value0.548
Fetal beta-0.814
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanNRC
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTC1ACTC | CMD1R | CMH11actin, alpha, cardiac muscle 1-HPRD12042308 
ATP6V1B1ATP6B1 | MGC32642 | RTA1B | VATB | VMA2 | VPP3ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1-HPRD10915794 
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alphaCAMK2A (CaMKII-alpha) interacts with ACTN4 (alpha-Actinin 4).BIND11160423 
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alphaTwo-hybridBioGRID11160423 
CAMK2BCAM2 | CAMK2 | CAMKB | MGC29528calcium/calmodulin-dependent protein kinase II betaTwo-hybridBioGRID11160423 
CAMK2BCAM2 | CAMK2 | CAMKB | MGC29528calcium/calmodulin-dependent protein kinase II betaCAMK2B (CaMKII-beta) interacts with ACTN4 (alpha-Actinin 4).BIND11160423 
CAMK2GCAMK | CAMK-II | CAMKG | FLJ16043 | MGC26678calcium/calmodulin-dependent protein kinase II gamma-HPRD11160423 
COL17A1BA16H23.2 | BP180 | BPAG2 | FLJ60881 | KIAA0204 | LAD-1collagen, type XVII, alpha 1-HPRD,BioGRID11739652 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)-HPRD,BioGRID11733011 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)-HPRD2116421 
LRRC7DKFZp686I1147 | KIAA1365 | MGC144918leucine rich repeat containing 7-HPRD11160423 
LRRC7DKFZp686I1147 | KIAA1365 | MGC144918leucine rich repeat containing 7LRRC7 (Densin-180) interacts with ACTN4 (alpha-Actinin 4). This interaction was modeled on a demonstrated interaction between rat LRCC7 and human ACTN4.BIND11160423 
MAGI1AIP3 | BAIAP1 | BAP1 | MAGI-1 | TNRC19 | WWP3membrane associated guanylate kinase, WW and PDZ domain containing 1-HPRD,BioGRID12042308 
MYOZ1CS-2 | FATZ | MYOZmyozenin 1Two-hybridBioGRID16189514 
MYOZ2C4orf5 | CS-1myozenin 2Two-hybridBioGRID16189514 
NEBDKFZp686C1456 | FLJ11505 | FLJ36536 | FLJ39568 | FLJ39584 | NEB177D | NEM2nebulin-HPRD11882289 
NOS2HEP-NOS | INOS | NOS | NOS2Anitric oxide synthase 2, inducible-HPRD12960352 
PDLIM1CLIM1 | CLP-36 | CLP36 | hCLIM1PDZ and LIM domain 1-HPRD,BioGRID10753915 
PDLIM1CLIM1 | CLP-36 | CLP36 | hCLIM1PDZ and LIM domain 1CLP-36 interacts with alpha-actinin 4.BIND10753915 
SLC9A3R2E3KARP | MGC104639 | NHE3RF2 | NHERF-2 | NHERF2 | OCTS2 | SIP-1 | SIP1 | TKA-1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2-HPRD,BioGRID11948184 
TRIM3BERP | FLJ16135 | HAC1 | RNF22 | RNF97tripartite motif-containing 3-HPRD,BioGRID10673389 
USP6NLKIAA0019 | RNTRE | TRE2NLUSP6 N-terminal like-HPRD,BioGRID15152255 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION 7553All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 140100All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC 7659All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 8956All SZGR 2.0 genes in this pathway
REACTOME NEPHRIN INTERACTIONS 2015All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA REVERSIBLY DN 2921All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 15093All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC 4431All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 13493All SZGR 2.0 genes in this pathway
TERAMOTO OPN TARGETS CLUSTER 6 2717All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292168All SZGR 2.0 genes in this pathway
TAGHAVI NEOPLASTIC TRANSFORMATION 1210All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 480 MCF10A 3920All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE UP 8054All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 7652All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN 9055All SZGR 2.0 genes in this pathway
LIN APC TARGETS 7755All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN 6647All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 UP 4430All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408274All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP 5635All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 11371All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 9671All SZGR 2.0 genes in this pathway
SAFFORD T LYMPHOCYTE ANERGY 8754All SZGR 2.0 genes in this pathway
GHO ATF5 TARGETS DN 1610All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 13293All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 8865All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 12589All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
QI HYPOXIA TARGETS OF HIF1A AND FOXA2 3727All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway