Gene Page: TRIM11

Summary ?
GeneID81559
SymbolTRIM11
SynonymsBIA1|RNF92
Descriptiontripartite motif containing 11
ReferenceMIM:607868|HGNC:HGNC:16281|Ensembl:ENSG00000154370|HPRD:07429|Vega:OTTHUMG00000039773
Gene typeprotein-coding
Map location1q42.13
Sherlock p-value0.254
Fetal beta-0.271
DMG1 (# studies)
eGeneCortex
Myers' cis & trans
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg174656971228594029TRIM111.8E-6-0.3430.008DMG:Wockner_2014
cg076020731228595680TRIM17;TRIM117.2E-50.4750.025DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407TRIM11815592.923E-8trans
rs7584986chr2184111432TRIM11815590.05trans
rs16955618chr1529937543TRIM11815597.985E-12trans
rs1041786chr2122617710TRIM11815590.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC023055.40.380.34
ACADVL0.340.31
MOV100.340.32
PLD20.330.33
NPHP30.330.29
USP400.330.29
ATHL10.330.28
PDE6B0.320.29
MYO15B0.320.30
DNHD10.320.31
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FAM163B-0.27-0.26
KCNF1-0.26-0.26
LNX1-0.25-0.27
HSPBP1-0.25-0.23
HS3ST2-0.25-0.25
CLTB-0.25-0.25
AC073610.6-0.24-0.26
CDK5R2-0.24-0.23
C1QTNF4-0.24-0.22
MATK-0.23-0.22

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS UP 6841All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378231All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE UP 8657All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway