Gene Page: TSPAN14
Summary ?
| GeneID | 81619 |
| Symbol | TSPAN14 |
| Synonyms | DC-TM4F2|TM4SF14 |
| Description | tetraspanin 14 |
| Reference | HGNC:HGNC:23303|Ensembl:ENSG00000108219|HPRD:18196|Vega:OTTHUMG00000018615 |
| Gene type | protein-coding |
| Map location | 10q23.1 |
| Pascal p-value | 0.106 |
| Sherlock p-value | 0.685 |
| DEG p-value | DEG:Zhao_2015:p=4.45e-04:q=0.0926 |
| Fetal beta | 1.239 |
| eGene | Cerebellar Hemisphere Cerebellum Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DEG:Zhao_2015 | RNA Sequencing analysis | Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder. |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7096909 | chr10 | 82284511 | TSPAN14 | 81619 | 0.05 | cis | ||
| rs2125040 | 10 | 82208422 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -5500 | gtex_brain_putamen_basal |
| rs7088877 | 10 | 82208860 | TSPAN14 | ENSG00000108219.10 | 2.888E-6 | 0.03 | -5062 | gtex_brain_putamen_basal |
| rs7095954 | 10 | 82209232 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -4690 | gtex_brain_putamen_basal |
| rs11202957 | 10 | 82209592 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -4330 | gtex_brain_putamen_basal |
| rs11202959 | 10 | 82209672 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -4250 | gtex_brain_putamen_basal |
| rs11202960 | 10 | 82209807 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -4115 | gtex_brain_putamen_basal |
| rs10887894 | 10 | 82209952 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -3970 | gtex_brain_putamen_basal |
| rs10887895 | 10 | 82210011 | TSPAN14 | ENSG00000108219.10 | 2.867E-6 | 0.03 | -3911 | gtex_brain_putamen_basal |
| rs10887896 | 10 | 82210144 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -3778 | gtex_brain_putamen_basal |
| rs10887900 | 10 | 82210265 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -3657 | gtex_brain_putamen_basal |
| rs11202963 | 10 | 82210392 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -3530 | gtex_brain_putamen_basal |
| rs10887901 | 10 | 82210581 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -3341 | gtex_brain_putamen_basal |
| rs10887902 | 10 | 82210616 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -3306 | gtex_brain_putamen_basal |
| rs10887903 | 10 | 82210641 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -3281 | gtex_brain_putamen_basal |
| rs10887905 | 10 | 82210855 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -3067 | gtex_brain_putamen_basal |
| rs7085606 | 10 | 82211290 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -2632 | gtex_brain_putamen_basal |
| rs7077373 | 10 | 82211615 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -2307 | gtex_brain_putamen_basal |
| rs12245180 | 10 | 82211897 | TSPAN14 | ENSG00000108219.10 | 2.896E-6 | 0.03 | -2025 | gtex_brain_putamen_basal |
| rs4933390 | 10 | 82213081 | TSPAN14 | ENSG00000108219.10 | 1.641E-6 | 0.03 | -841 | gtex_brain_putamen_basal |
| rs10887914 | 10 | 82215288 | TSPAN14 | ENSG00000108219.10 | 1.662E-6 | 0.03 | 1366 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ONKEN UVEAL MELANOMA DN | 526 | 357 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| RICKMAN METASTASIS DN | 261 | 155 | All SZGR 2.0 genes in this pathway |
| AMIT EGF RESPONSE 480 HELA | 164 | 118 | All SZGR 2.0 genes in this pathway |
| HADDAD B LYMPHOCYTE PROGENITOR | 293 | 193 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RESPONSE TO TRABECTEDIN DN | 271 | 175 | All SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
| HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN | 103 | 67 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |