SZGR2

Summary ?

GeneID	81857
Symbol	MED25
Synonyms	ACID1\|ARC92\|BVSYS\|CMT2B2\|P78\|PTOV2\|TCBAP0758
Description	mediator complex subunit 25
Reference	MIM:610197\|HGNC:HGNC:28845\|Ensembl:ENSG00000104973\|HPRD:14380\|Vega:OTTHUMG00000183161
Gene type	protein-coding
Map location	19q13.3
Pascal p-value	0.128
Sherlock p-value	0.776
Fetal beta	0.248
DMG	1 (# studies)
eGene	Myers' cis & trans Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg15647861	19	50320776	MED25	1.564E-4	-0.301	0.032	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs4854166	chr2	3297005	MED25	81857		0.2		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CDK8	K35 \| MGC126074 \| MGC126075	cyclin-dependent kinase 8	-	HPRD,BioGRID	14983011
HCFC1	CFF \| HCF-1 \| HCF1 \| HFC1 \| MGC70925 \| VCAF	host cell factor C1 (VP16-accessory protein)	-	HPRD	14983011
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	Affinity Capture-Western	BioGRID	14638676
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	-	HPRD	14983011
MED10	L6 \| MGC5309 \| NUT2 \| TRG20	mediator complex subunit 10	Affinity Capture-MS	BioGRID	15175163
MED11	HSPC296 \| MGC88387	mediator complex subunit 11	Affinity Capture-Western	BioGRID	14638676
MED15	ARC105 \| CAG7A \| CTG7A \| DKFZp686A2214 \| DKFZp762B1216 \| FLJ42282 \| FLJ42935 \| PCQAP \| TIG-1 \| TIG1 \| TNRC7	mediator complex subunit 15	-	HPRD,BioGRID	14983011
MED17	CRSP6 \| CRSP77 \| DRIP80 \| FLJ10812 \| TRAP80	mediator complex subunit 17	Affinity Capture-Western	BioGRID	14638676
MED18	FLJ20045 \| p28b	mediator complex subunit 18	Affinity Capture-Western	BioGRID	14638676
MED19	DT2P1G7 \| LCMR1	mediator complex subunit 19	Affinity Capture-MS Affinity Capture-Western	BioGRID	14638676 \|15175163
MED22	MED24 \| MGC48682 \| SURF5	mediator complex subunit 22	Affinity Capture-Western	BioGRID	14638676
MED26	CRSP7 \| CRSP70	mediator complex subunit 26	Affinity Capture-MS	BioGRID	15175163
MED28	1500003D12Rik \| DKFZp434N185 \| EG1 \| magicin	mediator complex subunit 28	Affinity Capture-MS	BioGRID	15175163
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	Affinity Capture-MS Affinity Capture-Western	BioGRID	14638676 \|15175163
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	-	HPRD	14576168
MED4	DRIP36 \| FLJ10956 \| HSPC126 \| RP11-90M2.2 \| TRAP36 \| VDRIP	mediator complex subunit 4	Affinity Capture-Western Reconstituted Complex	BioGRID	14638676
MED6	NY-REN-28	mediator complex subunit 6	-	HPRD,BioGRID	14983011
MED8	ARC32 \| MGC17544 \| MGC19641	mediator complex subunit 8	Affinity Capture-Western	BioGRID	14638676
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	-	HPRD	14638676
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	Affinity Capture-MS	BioGRID	15175163
TFF1	BCEI \| D21S21 \| HP1.A \| HPS2 \| pNR-2 \| pS2	trefoil factor 1	MED25 interacts with pS2 promoter.	BIND	15989967

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION	104	72	All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY	352	181	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE	261	166	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 1 DN	48	30	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 DN	42	24	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 4 DN	15	9	All SZGR 2.0 genes in this pathway

Gene Page: MED25