SZGR2

Summary ?

GeneID	821
Symbol	CANX
Synonyms	CNX\|IP90\|P90
Description	calnexin
Reference	MIM:114217\|HGNC:HGNC:1473\|Ensembl:ENSG00000127022\|HPRD:00252\|Vega:OTTHUMG00000130910
Gene type	protein-coding
Map location	5q35
Pascal p-value	0.105
Sherlock p-value	0.197
Fetal beta	-0.129
eGene	Cortex Meta
Support	RNA AND PROTEIN SYNTHESIS CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
DNM:Xu_2012	Whole Exome Sequencing analysis	De novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.0276

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
CANX	chr5	179136974	A	G	NM_001024649 NM_001746	p.210K>R p.210K>R	missense missense			Schizophrenia	DNM:Xu_2012

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
GJB1	0.95	0.90
KLK6	0.94	0.90
SLC5A11	0.93	0.93
MOG	0.93	0.91
TF	0.92	0.92
SLC31A2	0.92	0.82
PLA2G16	0.92	0.91
DBNDD2	0.92	0.90
PPAP2C	0.91	0.85
SGK2	0.91	0.92

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
NKIRAS2	-0.55	-0.71
CRMP1	-0.53	-0.69
TUBB2B	-0.53	-0.78
HN1	-0.52	-0.71
HMGB3	-0.52	-0.72
KIAA1949	-0.52	-0.71
TUBB	-0.52	-0.72
YBX1	-0.52	-0.78
PCDHB18	-0.51	-0.70
CD24	-0.51	-0.71

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005529	sugar binding	IEA		-
GO:0005509	calcium ion binding	IEA		-
GO:0005509	calcium ion binding	TAS		8136357
GO:0051082	unfolded protein binding	IEA		-
GO:0051082	unfolded protein binding	NAS		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001525	angiogenesis	IDA		15467828
GO:0006457	protein folding	IEA		-
GO:0009306	protein secretion	TAS		8055875
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005789	endoplasmic reticulum membrane	IEA		-
GO:0005737	cytoplasm	IDA		15467828
GO:0005783	endoplasmic reticulum	IDA		14966132 \|15467828
GO:0005783	endoplasmic reticulum	IEA		-
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	IEA		-
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABCC2	ABC30 \| CMOAT \| DJS \| KIAA1010 \| MRP2 \| cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	-	HPRD	12222674
APOB	FLDB	apolipoprotein B (including Ag(x) antigen)	Affinity Capture-Western	BioGRID	14498830
BCAP31	6C6-AG \| BAP31 \| CDM \| DXS1357E	B-cell receptor-associated protein 31	-	HPRD	11851433
CALR	CRT \| FLJ26680 \| RO \| SSA \| cC1qR	calreticulin	Affinity Capture-Western	BioGRID	10436013
CD1D	CD1A \| MGC34622 \| R3	CD1d molecule	-	HPRD,BioGRID	12239218
CD3D	CD3-DELTA \| T3D	CD3d molecule, delta (CD3-TCR complex)	-	HPRD,BioGRID	8278814 \|8621641
CD82	4F9 \| C33 \| GR15 \| IA4 \| KAI1 \| R2 \| SAR2 \| ST6 \| TSPAN27	CD82 molecule	-	HPRD	11350933
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	CFTR interacts with CANX. This interaction was modeled on a demonstrated interaction between human CFTR and hamster CANX.	BIND	15105504
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	CFTR interacts with CANX.	BIND	7513695
EBI3	IL27B	Epstein-Barr virus induced 3	-	HPRD,BioGRID	8551575
EDEM1	EDEM \| FLJ51559 \| FLJ51560 \| KIAA0212	ER degradation enhancer, mannosidase alpha-like 1	-	HPRD,BioGRID	12610305
F8	AHF \| DXS1253E \| F8B \| F8C \| FVIII \| HEMA	coagulation factor VIII, procoagulant component	-	HPRD,BioGRID	9525969
GRIA1	GLUH1 \| GLUR1 \| GLURA \| HBGR1 \| MGC133252	glutamate receptor, ionotropic, AMPA 1	-	HPRD	10461883
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	11506858 \|14732708
HTR3A	5-HT-3 \| 5-HT3A \| 5-HT3R \| 5HT3R \| HTR3	5-hydroxytryptamine (serotonin) receptor 3A	-	HPRD	12359150
ITGA6	CD49f \| DKFZp686J01244 \| FLJ18737 \| ITGA6B \| VLA-6	integrin, alpha 6	-	HPRD	8163531
ITGB1	CD29 \| FNRB \| GPIIA \| MDF2 \| MSK12 \| VLA-BETA \| VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	-	HPRD,BioGRID	8163531
LCT	LAC \| LPH \| LPH1	lactase	-	HPRD,BioGRID	11751874
LPA	AK38 \| APOA \| LP	lipoprotein, Lp(a)	-	HPRD,BioGRID	9717723 \|12562843
LRP1	A2MR \| APOER \| APR \| CD91 \| FLJ16451 \| IGFBP3R \| LRP \| MGC88725 \| TGFBR5	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	-	HPRD,BioGRID	14980518
MBTPS1	KIAA0091 \| MGC138711 \| MGC138712 \| PCSK8 \| S1P \| SKI-1	membrane-bound transcription factor peptidase, site 1	-	HPRD	11756446
PDIA3	ER60 \| ERp57 \| ERp60 \| ERp61 \| GRP57 \| GRP58 \| HsT17083 \| P58 \| PI-PLC	protein disulfide isomerase family A, member 3	ERp57 interacts with CNX. This interaction was modeled on a demonstrated interaction between dog CNX and ERp57 from an unspecified source.	BIND	12052826
PDIA3	ER60 \| ERp57 \| ERp60 \| ERp61 \| GRP57 \| GRP58 \| HsT17083 \| P58 \| PI-PLC	protein disulfide isomerase family A, member 3	-	HPRD	10436013
PIGK	GPI8 \| MGC22559	phosphatidylinositol glycan anchor biosynthesis, class K	Affinity Capture-MS	BioGRID	12582175
PRKCSH	AGE-R2 \| G19P1 \| PCLD \| PLD1	protein kinase C substrate 80K-H	-	HPRD	8910335
SERP1	MGC117327 \| MGC133321 \| MGC133322 \| RAMP4	stress-associated endoplasmic reticulum protein 1	-	HPRD	10601334
SLC2A1	DYT17 \| DYT18 \| GLUT \| GLUT1 \| MGC141895 \| MGC141896 \| PED	solute carrier family 2 (facilitated glucose transporter), member 1	-	HPRD,BioGRID	8662691
SLC4A1	AE1 \| BND3 \| CD233 \| DI \| EMPB3 \| EPB3 \| FR \| MGC116750 \| MGC116753 \| MGC126619 \| MGC126623 \| RTA1A \| SW \| WD \| WD1 \| WR	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	-	HPRD,BioGRID	10364201
SLC6A4	5-HTT \| 5HTT \| HTT \| OCD1 \| SERT \| hSERT	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Reconstituted Complex	BioGRID	10364189
TF	DKFZp781D0156 \| PRO1557 \| PRO2086	transferrin	-	HPRD,BioGRID	9312001
TG	AITD3 \| TGN	thyroglobulin	-	HPRD	10636893
TRA@	FLJ22602 \| MGC117436 \| MGC22624 \| MGC23964 \| MGC71411 \| TCRA \| TCRD \| TRA	T cell receptor alpha locus	-	HPRD	11566319
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	Thyroid-Stimulating Hormone Receptor interacts with the molecular chaperone calnexin. This interaction was modeled on a demonstrated interaction between human TSHR and dog calnexin.	BIND	12383251
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	-	HPRD,BioGRID	12383251

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ANTIGEN PROCESSING AND PRESENTATION	89	65	All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION	91	61	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS	518	242	All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	188	116	All SZGR 2.0 genes in this pathway
REACTOME ASPARAGINE N LINKED GLYCOSYLATION	81	54	All SZGR 2.0 genes in this pathway
REACTOME CALNEXIN CALRETICULIN CYCLE	11	7	All SZGR 2.0 genes in this pathway
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	13	9	All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE	203	72	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	21	17	All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	251	156	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN	267	178	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN	493	298	All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS DN	51	35	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN	214	133	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN	199	124	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES DN	16	10	All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER	178	108	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP	390	236	All SZGR 2.0 genes in this pathway
TOMLINS PROSTATE CANCER UP	40	27	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX4 DN	32	22	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN	169	102	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE UP	78	51	All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION	171	102	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR DN	41	30	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP	63	48	All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS UP	29	23	All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP	81	52	All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE	64	47	All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN	40	31	All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS	138	91	All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS DN	29	16	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS UP	66	43	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL	311	205	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN	49	38	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
GRADE COLON VS RECTAL CANCER UP	38	21	All SZGR 2.0 genes in this pathway
CUI GLUCOSE DEPRIVATION	60	44	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP	245	159	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN	210	128	All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM UP	47	30	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 MULTIPLE MYELOMA PROGRAM	36	25	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE	101	76	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE	67	51	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE	81	66	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED DENDRITIC CELL	65	49	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
GUTIERREZ MULTIPLE MYELOMA UP	35	24	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10	69	38	All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 VIA ERCC6 UP	40	30	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA VIA VHL	34	24	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN	784	464	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A	182	108	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	858	864	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	858	864	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-130/301	1543	1549	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-139	204	210	1A	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-148/152	1544	1551	1A,m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-153	918	924	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-205	1616	1622	m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-29	1403	1409	1A	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-30-3p	1461	1467	m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
				hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-374	965	971	1A	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-494	1009	1015	m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-496	1280	1286	m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-505	864	870	m8	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CANX