Gene Page: CANX

Summary
GeneID  821
Symbol  CANX
Synonyms  CNX|FLJ26570|IP90|P90
Description  calnexin
See related  HGNC:1473|MIM:114217|Ensembl:ENSG00000127022|HPRD:00252|
Locus tag  -
Gene type  protein-coding
Map location  5q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.0276 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GJB10.950.90
KLK60.940.90
SLC5A110.930.93
MOG0.930.91
TF0.920.92
SLC31A20.920.82
PLA2G160.920.91
DBNDD20.920.90
PPAP2C0.910.85
SGK20.910.92
Top 10 negatively co-expressed genes
NKIRAS2-0.55-0.71
CRMP1-0.53-0.69
TUBB2B-0.53-0.78
HN1-0.52-0.71
HMGB3-0.52-0.72
KIAA1949-0.52-0.71
TUBB-0.52-0.72
YBX1-0.52-0.78
PCDHB18-0.51-0.70
CD24-0.51-0.71
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005529sugar bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0005509calcium ion bindingTAS8136357 
GO:0051082unfolded protein bindingIEA-
GO:0051082unfolded protein bindingNAS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001525angiogenesisIDA15467828 
GO:0006457protein foldingIEA-
GO:0009306protein secretionTAS8055875 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005737cytoplasmIDA15467828 
GO:0005783endoplasmic reticulumIDA14966132 |15467828 
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0042470melanosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABCC2ABC30 | CMOAT | DJS | KIAA1010 | MRP2 | cMRPATP-binding cassette, sub-family C (CFTR/MRP), member 2-HPRD12222674 
APOBFLDBapolipoprotein B (including Ag(x) antigen)Affinity Capture-WesternBioGRID14498830 
BCAP316C6-AG | BAP31 | CDM | DXS1357EB-cell receptor-associated protein 31-HPRD11851433 
CALRCRT | FLJ26680 | RO | SSA | cC1qRcalreticulinAffinity Capture-WesternBioGRID10436013 
CD1DCD1A | MGC34622 | R3CD1d molecule-HPRD,BioGRID12239218 
CD3DCD3-DELTA | T3DCD3d molecule, delta (CD3-TCR complex)-HPRD,BioGRID8278814 |8621641 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 molecule-HPRD11350933 
CFTRABC35 | ABCC7 | CF | CFTR/MRP | MRP7 | TNR-CFTR | dJ760C5.1cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)CFTR interacts with CANX. This interaction was modeled on a demonstrated interaction between human CFTR and hamster CANX.BIND15105504 
CFTR interacts with CANX.BIND7513695 
EBI3IL27BEpstein-Barr virus induced 3-HPRD,BioGRID8551575 
EDEM1EDEM | FLJ51559 | FLJ51560 | KIAA0212ER degradation enhancer, mannosidase alpha-like 1-HPRD,BioGRID12610305 
F8AHF | DXS1253E | F8B | F8C | FVIII | HEMAcoagulation factor VIII, procoagulant component-HPRD,BioGRID9525969 
GRIA1GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252glutamate receptor, ionotropic, AMPA 1-HPRD10461883 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD11506858 |14732708 
HTR3A5-HT-3 | 5-HT3A | 5-HT3R | 5HT3R | HTR35-hydroxytryptamine (serotonin) receptor 3A-HPRD12359150 
ITGA6CD49f | DKFZp686J01244 | FLJ18737 | ITGA6B | VLA-6integrin, alpha 6-HPRD8163531 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)-HPRD,BioGRID8163531 
LCTLAC | LPH | LPH1lactase-HPRD,BioGRID11751874 
LPAAK38 | APOA | LPlipoprotein, Lp(a)-HPRD,BioGRID9717723 |12562843 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD,BioGRID14980518 
MBTPS1KIAA0091 | MGC138711 | MGC138712 | PCSK8 | S1P | SKI-1membrane-bound transcription factor peptidase, site 1-HPRD11756446 
PDIA3ER60 | ERp57 | ERp60 | ERp61 | GRP57 | GRP58 | HsT17083 | P58 | PI-PLCprotein disulfide isomerase family A, member 3ERp57 interacts with CNX. This interaction was modeled on a demonstrated interaction between dog CNX and ERp57 from an unspecified source.BIND12052826 
-HPRD10436013 
PIGKGPI8 | MGC22559phosphatidylinositol glycan anchor biosynthesis, class KAffinity Capture-MSBioGRID12582175 
PRKCSHAGE-R2 | G19P1 | PCLD | PLD1protein kinase C substrate 80K-H-HPRD8910335 
SERP1MGC117327 | MGC133321 | MGC133322 | RAMP4stress-associated endoplasmic reticulum protein 1-HPRD10601334 
SLC2A1DYT17 | DYT18 | GLUT | GLUT1 | MGC141895 | MGC141896 | PEDsolute carrier family 2 (facilitated glucose transporter), member 1-HPRD,BioGRID8662691 
SLC4A1AE1 | BND3 | CD233 | DI | EMPB3 | EPB3 | FR | MGC116750 | MGC116753 | MGC126619 | MGC126623 | RTA1A | SW | WD | WD1 | WRsolute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)-HPRD,BioGRID10364201 
SLC6A45-HTT | 5HTT | HTT | OCD1 | SERT | hSERTsolute carrier family 6 (neurotransmitter transporter, serotonin), member 4Reconstituted ComplexBioGRID10364189 
TFDKFZp781D0156 | PRO1557 | PRO2086transferrin-HPRD,BioGRID9312001 
TGAITD3 | TGNthyroglobulin-HPRD10636893 
TRA@FLJ22602 | MGC117436 | MGC22624 | MGC23964 | MGC71411 | TCRA | TCRD | TRAT cell receptor alpha locus-HPRD11566319 
TSHRCHNG1 | LGR3 | MGC75129 | hTSHR-Ithyroid stimulating hormone receptorThyroid-Stimulating Hormone Receptor interacts with the molecular chaperone calnexin. This interaction was modeled on a demonstrated interaction between human TSHR and dog calnexin.BIND12383251 
-HPRD,BioGRID12383251 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 9161All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 188116All SZGR genes in this pathway
REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION 8154All SZGR genes in this pathway
REACTOME_CALNEXIN_CALRETICULIN_CYCLE 117All SZGR genes in this pathway
REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE 139All SZGR genes in this pathway
REACTOME_INFLUENZA_LIFE_CYCLE 20372All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 2117All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_DN 5135All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_DN 1610All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
TOMLINS_PROSTATE_CANCER_UP 4027All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX4_DN 3222All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_DN 169102All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_UP 7851All SZGR genes in this pathway
GOLDRATH_HOMEOSTATIC_PROLIFERATION 171102All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN 4130All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN 12179All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 6348All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_UP 2923All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_UP 8152All SZGR genes in this pathway
RHODES_CANCER_META_SIGNATURE 6447All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_DN 4031All SZGR genes in this pathway
JIANG_VHL_TARGETS 13891All SZGR genes in this pathway
PAL_PRMT5_TARGETS_DN 2916All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
RAMASWAMY_METASTASIS_UP 6643All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN 4938All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
GRADE_COLON_VS_RECTAL_CANCER_UP 3821All SZGR genes in this pathway
CUI_GLUCOSE_DEPRIVATION 6044All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_UP 4730All SZGR genes in this pathway
SHAFFER_IRF4_MULTIPLE_MYELOMA_PROGRAM 3625All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE 10176All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE 6751All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_ACTIVATED_B_LYMPHOCYTE 8166All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_ACTIVATED_DENDRITIC_CELL 6549All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
GUTIERREZ_MULTIPLE_MYELOMA_UP 3524All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_10 6938All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_UP 4030All SZGR genes in this pathway
JIANG_HYPOXIA_VIA_VHL 3424All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128858864m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-130/30115431549m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1392042101Ahsa-miR-139brainUCUACAGUGCACGUGUCU
miR-148/152154415511A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-153918924m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-20516161622m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-29140314091Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-30-3p14611467m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-3749659711Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-49410091015m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-49612801286m8hsa-miR-496AUUACAUGGCCAAUCUC
miR-505864870m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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