Gene Page: AXIN1

Summary
GeneID  8312
Symbol  AXIN1
Synonyms  AXIN|MGC52315
Description  axin 1
See related  HGNC:903|MIM:603816|Ensembl:ENSG00000103126|HPRD:04819|
Locus tag  LA16c-314G4.3
Gene type  protein-coding
Map location  16p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0179 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityNAS9230313 
GO:0005515protein bindingIPI9601641 |12192039 
GO:0042803protein homodimerization activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007605sensory perception of soundIEA-
GO:0006915apoptosisIEA-
GO:0007309oocyte axis specificationTAS9230313 
GO:0007275multicellular organismal developmentIEA-
GO:0030178negative regulation of Wnt receptor signaling pathwayIEA-
GO:0030163protein catabolic processIEA-
GO:0045786negative regulation of cell cycleIEA-
GO:0046330positive regulation of JNK cascadeISS-
GO:0060070Wnt receptor signaling pathway through beta-cateninIC9601641 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP11955436 |12000790 |12820959 
|15327769 |16753179 
GO:0005622intracellularIEA-
GO:0005634nucleusIDA12072559 
GO:0005737cytoplasmIDA12072559 
GO:0016023cytoplasmic membrane-bounded vesicleIEA-
GO:0016328lateral plasma membraneIDA12072559 
GO:0030877beta-catenin destruction complexIDA9601641 |16188939 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANP32AC15orf1 | I1PP2A | LANP | MAPM | MGC119787 | MGC150373 | PHAP1 | PHAPI | PP32acidic (leucine-rich) nuclear phosphoprotein 32 family, member ATwo-hybridBioGRID16169070 
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coliReconstituted Complex
Two-hybrid		BioGRID9734785 
-HPRD11297546 
AXIN1AXIN | MGC52315axin 1Affinity Capture-Western
Two-hybrid		BioGRID11884395 |16169070 
CRMP1DPYSL1 | DRP-1 | DRP1collapsin response mediator protein 1Two-hybridBioGRID16169070 
CSNK1A1CK1 | HLCDGP1 | PRO2975casein kinase 1, alpha 1-HPRD,BioGRID11884395 
CSNK1EHCKIE | MGC10398casein kinase 1, epsilonAffinity Capture-Western
Phenotypic Suppression		BioGRID11884395 
-HPRD11487578 |12000790 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9734785 |12805222 
-HPRD12000790 
DAB2DOC-2 | DOC2 | FLJ26626disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)Reconstituted ComplexBioGRID12805222 
DIXDC1CCD1 | KIAA1735DIX domain containing 1-HPRD15262978 
DVL1DVL | MGC54245dishevelled, dsh homolog 1 (Drosophila)Affinity Capture-WesternBioGRID10428961 
-HPRD9482734 |10330403 
DVL2-dishevelled, dsh homolog 2 (Drosophila)-HPRD,BioGRID10829020 
DVL3KIAA0208dishevelled, dsh homolog 3 (Drosophila)Affinity Capture-WesternBioGRID12805222 
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1Two-hybridBioGRID16169070 
GAKFLJ16629 | FLJ40395 | MGC99654cyclin G associated kinaseTwo-hybridBioGRID16169070 
GSK3B-glycogen synthase kinase 3 betaAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9734785 |12511557 
LRP5BMND1 | EVR1 | EVR4 | HBM | LR3 | LRP7 | OPPG | OPS | OPTA1 | VBCH2low density lipoprotein receptor-related protein 5-HPRD,BioGRID11336703 
MAP3K1MAPKKK1 | MEKK | MEKK1mitogen-activated protein kinase kinase kinase 1Affinity Capture-WesternBioGRID10829020 |11884395 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD11557983 
PIAS1DDXBP1 | GBP | GU/RH-II | MGC141878 | MGC141879 | ZMIZ3protein inhibitor of activated STAT, 1-HPRD12223491 
PPP2R5AB56A | MGC131915 | PR61Aprotein phosphatase 2, regulatory subunit B', alpha isoformAffinity Capture-Western
Reconstituted Complex		BioGRID11297546 
SENP2AXAM2 | DKFZp762A2316 | KIAA1331 | SMT3IP2SUMO1/sentrin/SMT3 specific peptidase 2-HPRD11997515 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD11438668 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD11438668 
SMYD2HSKM-B | KMT3C | MGC119305 | ZMYND14SET and MYND domain containing 2Affinity Capture-MSBioGRID17353931 
TSC1KIAA0243 | LAM | MGC86987 | TSCtuberous sclerosis 1Affinity Capture-WesternBioGRID12511557 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Affinity Capture-WesternBioGRID12511557 
UTP14AKIAA0266 | NY-CO-16 | SDCCAG16 | dJ537K23.3UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA 5544All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_GSK3_PATHWAY 2726All SZGR genes in this pathway
BIOCARTA_PITX2_PATHWAY 1515All SZGR genes in this pathway
BIOCARTA_PS1_PATHWAY 1414All SZGR genes in this pathway
BIOCARTA_WNT_PATHWAY 2624All SZGR genes in this pathway
WNT_SIGNALING 8971All SZGR genes in this pathway
ST_WNT_BETA_CATENIN_PATHWAY 3428All SZGR genes in this pathway
PID_BETA_CATENIN_DEG_PATHWAY 1817All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_WNT_CANONICAL_PATHWAY 2018All SZGR genes in this pathway
PID_MYC_PATHWAY 2522All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY 3332All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_SIGNALING_BY_WNT 6541All SZGR genes in this pathway
REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE 1611All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_DN 8748All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 12049All SZGR genes in this pathway
LAMB_CCND1_TARGETS 1914All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_DN 3825All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_DN 8759All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
SWEET_KRAS_ONCOGENIC_SIGNATURE 8956All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/506433439m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-128464470m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-203.1558564m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-31454460m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-493-5p554560m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-5395605671A,m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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