Gene Page: CASP1

Summary
GeneID  834
Symbol  CASP1
Synonyms  ICE|IL1BC|P45
Description  caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
See related  HGNC:1499|MIM:147678|Ensembl:ENSG00000137752|HPRD:00977|
Locus tag  -
Gene type  protein-coding
Map location  11q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 2.5585 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI12888622 |15107016 
GO:0004197cysteine-type endopeptidase activityIEA-
GO:0004197cysteine-type endopeptidase activityTAS10353249 
GO:0008656caspase activator activityTAS10799503 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001666response to hypoxiaIEA-
GO:0006508proteolysisIDA12888622 
GO:0006508proteolysisIEA-
GO:0008219cell deathIEA-
GO:0006917induction of apoptosisIEA-
GO:0007165signal transductionTAS1373520 
GO:0042981regulation of apoptosisIEA-
GO:0016485protein processingIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005622intracellularIEA-
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAndrogen Receptor interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human androgen receptor and caspase 1 from an unspecified species.BIND9535906 
ATN1B37 | D12S755E | DRPLA | NODatrophin 1Atrophin-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human atrophin-1 and caspase 1 from an unspecified species.BIND9535906 
ATXN3AT3 | ATX3 | JOS | MJD | MJD1 | SCA3ataxin 3Ataxin-3 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human ataxin-3 and caspase 1 from an unspecified species.BIND9535906 
-HPRD9535906 
BCAP316C6-AG | BAP31 | CDM | DXS1357EB-cell receptor-associated protein 31-HPRD,BioGRID9334338 
CARD16COP | COP1 | PSEUDO-ICEcaspase recruitment domain family, member 16-HPRD11432859 |11536016 
CARD17INCAcaspase recruitment domain family, member 17-HPRD15383541 
CARD8CARDINAL | DACAR | DKFZp779L0366 | Dakar | FLJ18119 | FLJ18121 | KIAA0955 | MGC57162 | NDPP | NDPP1 | TUCANcaspase recruitment domain family, member 8-HPRD11821383 
CARD-8 interacts with Casp-1BIND11821383 
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)-HPRD9190289 
Affinity Capture-WesternBioGRID11432859 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID8962078 
CASP14MGC119078 | MGC119079caspase 14, apoptosis-related cysteine peptidase-HPRD,BioGRID9792675 
CASP4ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TXcaspase 4, apoptosis-related cysteine peptidaseReconstituted ComplexBioGRID10477277 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID8962078 
COPCLTOclathrin-ordered proteinAffinity Capture-WesternBioGRID11432859 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID11226410 
HTTHD | IT15huntingtinHuntingtin interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human huntingtin and caspase 1 from an unspecified species.BIND9535906 
-HPRD9535906 
IL18IGIF | IL-18 | IL-1g | IL1F4 | MGC12320interleukin 18 (interferon-gamma-inducing factor)Biochemical ActivityBioGRID12096920 
IL1F7FIL1 | FIL1(ZETA) | FIL1Z | IL-1F7 | IL-1H4 | IL-1RP1 | IL1H4 | IL1RP1interleukin 1 family, member 7 (zeta)Biochemical ActivityBioGRID12096920 
NANACneurocanthocytosisAffinity Capture-WesternBioGRID15107016 
NFE2L2NRF2nuclear factor (erythroid-derived 2)-like 2-HPRD,BioGRID10510468 
NLRC4CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAFNLR family, CARD domain containing 4-HPRD,BioGRID11472070 
CARD12 (CLAN) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD12 and CASP1 from an unspecified species.BIND15107016 
-HPRD11390368 |11472070|11472070 
NLRP1CARD7 | CLR17.1 | DEFCAP | DEFCAP-L/S | DKFZp586O1822 | KIAA0926 | NAC | NALP1 | PP1044 | SLEV1 | VAMAS1NLR family, pyrin domain containing 1NALP1 (NAC) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human NALP1 and CASP1 from an unspecified species.BIND15107016 
NOD1CARD4 | CLR7.1 | NLRC1nucleotide-binding oligomerization domain containing 1-HPRD,BioGRID10329646 
NOD2ACUG | BLAU | CARD15 | CD | CLR16.3 | IBD1 | NLRC2 | NOD2B | PSORAS1nucleotide-binding oligomerization domain containing 2Affinity Capture-WesternBioGRID15107016 
CARD15 (Nod2) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD15 and CASP1 from an unspecified species.BIND15107016 
PARK2AR-JP | LPRS2 | PDJ | PRKNParkinson disease (autosomal recessive, juvenile) 2, parkin-HPRD12692130 
PSEN1AD3 | FAD | PS1 | S182presenilin 1PS-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 1.BIND10069390 
PYCARDASC | CARD5 | MGC10332 | TMS | TMS-1 | TMS1PYD and CARD domain containing-HPRD11967258 |12019269 
|12191486 
RIPK2CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2receptor-interacting serine-threonine kinase 2-HPRD,BioGRID9705938 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 5644All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
BIOCARTA_CASPASE_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_D4GDI_PATHWAY 138All SZGR genes in this pathway
PID_IL1_PATHWAY 3428All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_IFNG_PATHWAY 4034All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
PID_ANTHRAX_PATHWAY 1715All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_NOD1_2_SIGNALING_PATHWAY 3022All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_THE_NLRP3_INFLAMMASOME 129All SZGR genes in this pathway
REACTOME_INFLAMMASOMES 1712All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 4633All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_DN 6039All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_DN 7351All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_DN 12984All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_UP 12171All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
BAKER_HEMATOPOESIS_STAT1_TARGETS 109All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_UP 8858All SZGR genes in this pathway
SCHAVOLT_TARGETS_OF_TP53_AND_TP63 1612All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN 9558All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
KHETCHOUMIAN_TRIM24_TARGETS_UP 4738All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
GUENTHER_GROWTH_SPHERICAL_VS_ADHERENT_DN 2619All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_DN 7652All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ZEILSTRA_CD44_TARGETS_DN 75All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
SANA_RESPONSE_TO_IFNG_UP 7850All SZGR genes in this pathway
SANA_TNF_SIGNALING_UP 8356All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_11Q23_DELETION 2318All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_UP 6446All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
SCHURINGA_STAT5A_TARGETS_DN 1810All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
HU_GENOTOXIC_DAMAGE_24HR 3522All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
BROWNE_INTERFERON_RESPONSIVE_GENES 6844All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_UP 7456All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
BILD_SRC_ONCOGENIC_SIGNATURE 6238All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_UP 7440All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_DN 3624All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP 12692All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_DN 7834All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_UP 5838All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
ONO_FOXP3_TARGETS_DN 4223All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS 4430All SZGR genes in this pathway
GYORFFY_DOXORUBICIN_RESISTANCE 5634All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_DN 6938All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_9 7645All SZGR genes in this pathway
NIELSEN_GIST_VS_SYNOVIAL_SARCOMA_DN 2017All SZGR genes in this pathway
NIELSEN_SYNOVIAL_SARCOMA_DN 2013All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway


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