Summary ?
GeneID834
SymbolCASP1
SynonymsICE|IL1BC|P45
Descriptioncaspase 1
ReferenceMIM:147678|HGNC:HGNC:1499|Ensembl:ENSG00000137752|HPRD:00977|Vega:OTTHUMG00000048072
Gene typeprotein-coding
Map location11q23
Pascal p-value0.046
DEG p-valueDEG:Sanders_2014:DS1_p=0.143:DS1_beta=0.049100:DS2_p=4.63e-02:DS2_beta=-0.097:DS2_FDR=1.89e-01
Fetal beta-0.289

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DEG:Sanders_2013MicroarrayWhole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
GSMA_IGenome scan meta-analysisPsr: 0.006 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 2.5585 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI12888622 |15107016 
GO:0004197cysteine-type endopeptidase activityIEA-
GO:0004197cysteine-type endopeptidase activityTAS10353249 
GO:0008656caspase activator activityTAS10799503 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001666response to hypoxiaIEA-
GO:0006508proteolysisIDA12888622 
GO:0006508proteolysisIEA-
GO:0008219cell deathIEA-
GO:0006917induction of apoptosisIEA-
GO:0007165signal transductionTAS1373520 
GO:0042981regulation of apoptosisIEA-
GO:0016485protein processingIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005622intracellularIEA-
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAndrogen Receptor interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human androgen receptor and caspase 1 from an unspecified species.BIND9535906 
ATN1B37 | D12S755E | DRPLA | NODatrophin 1Atrophin-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human atrophin-1 and caspase 1 from an unspecified species.BIND9535906 
ATXN3AT3 | ATX3 | JOS | MJD | MJD1 | SCA3ataxin 3Ataxin-3 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human ataxin-3 and caspase 1 from an unspecified species.BIND9535906 
ATXN3AT3 | ATX3 | JOS | MJD | MJD1 | SCA3ataxin 3-HPRD9535906 
BCAP316C6-AG | BAP31 | CDM | DXS1357EB-cell receptor-associated protein 31-HPRD,BioGRID9334338 
CARD16COP | COP1 | PSEUDO-ICEcaspase recruitment domain family, member 16-HPRD11432859 |11536016 
CARD17INCAcaspase recruitment domain family, member 17-HPRD15383541 
CARD8CARDINAL | DACAR | DKFZp779L0366 | Dakar | FLJ18119 | FLJ18121 | KIAA0955 | MGC57162 | NDPP | NDPP1 | TUCANcaspase recruitment domain family, member 8-HPRD11821383 
CARD8CARDINAL | DACAR | DKFZp779L0366 | Dakar | FLJ18119 | FLJ18121 | KIAA0955 | MGC57162 | NDPP | NDPP1 | TUCANcaspase recruitment domain family, member 8CARD-8 interacts with Casp-1BIND11821383 
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)-HPRD9190289 
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)Affinity Capture-WesternBioGRID11432859 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID8962078 
CASP14MGC119078 | MGC119079caspase 14, apoptosis-related cysteine peptidase-HPRD,BioGRID9792675 
CASP4ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TXcaspase 4, apoptosis-related cysteine peptidaseReconstituted ComplexBioGRID10477277 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID8962078 
COPCLTOclathrin-ordered proteinAffinity Capture-WesternBioGRID11432859 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID11226410 
HTTHD | IT15huntingtinHuntingtin interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human huntingtin and caspase 1 from an unspecified species.BIND9535906 
HTTHD | IT15huntingtin-HPRD9535906 
IL18IGIF | IL-18 | IL-1g | IL1F4 | MGC12320interleukin 18 (interferon-gamma-inducing factor)Biochemical ActivityBioGRID12096920 
IL1F7FIL1 | FIL1(ZETA) | FIL1Z | IL-1F7 | IL-1H4 | IL-1RP1 | IL1H4 | IL1RP1interleukin 1 family, member 7 (zeta)Biochemical ActivityBioGRID12096920 
NANACneurocanthocytosisAffinity Capture-WesternBioGRID15107016 
NFE2L2NRF2nuclear factor (erythroid-derived 2)-like 2-HPRD,BioGRID10510468 
NLRC4CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAFNLR family, CARD domain containing 4-HPRD,BioGRID11472070 
NLRC4CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAFNLR family, CARD domain containing 4CARD12 (CLAN) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD12 and CASP1 from an unspecified species.BIND15107016 
NLRC4CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAFNLR family, CARD domain containing 4-HPRD11390368 |11472070|11472070 
NLRP1CARD7 | CLR17.1 | DEFCAP | DEFCAP-L/S | DKFZp586O1822 | KIAA0926 | NAC | NALP1 | PP1044 | SLEV1 | VAMAS1NLR family, pyrin domain containing 1NALP1 (NAC) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human NALP1 and CASP1 from an unspecified species.BIND15107016 
NOD1CARD4 | CLR7.1 | NLRC1nucleotide-binding oligomerization domain containing 1-HPRD,BioGRID10329646 
NOD2ACUG | BLAU | CARD15 | CD | CLR16.3 | IBD1 | NLRC2 | NOD2B | PSORAS1nucleotide-binding oligomerization domain containing 2Affinity Capture-WesternBioGRID15107016 
NOD2ACUG | BLAU | CARD15 | CD | CLR16.3 | IBD1 | NLRC2 | NOD2B | PSORAS1nucleotide-binding oligomerization domain containing 2CARD15 (Nod2) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD15 and CASP1 from an unspecified species.BIND15107016 
PARK2AR-JP | LPRS2 | PDJ | PRKNParkinson disease (autosomal recessive, juvenile) 2, parkin-HPRD12692130 
PSEN1AD3 | FAD | PS1 | S182presenilin 1PS-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 1.BIND10069390 
PYCARDASC | CARD5 | MGC10332 | TMS | TMS-1 | TMS1PYD and CARD domain containing-HPRD11967258 |12019269 
|12191486 
RIPK2CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2receptor-interacting serine-threonine kinase 2-HPRD,BioGRID9705938 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 6247All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY 5644All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 5343All SZGR 2.0 genes in this pathway
BIOCARTA CASPASE PATHWAY 2315All SZGR 2.0 genes in this pathway
BIOCARTA D4GDI PATHWAY 138All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY 3428All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 13794All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY 4034All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY 5239All SZGR 2.0 genes in this pathway
PID ANTHRAX PATHWAY 1715All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY 3022All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
REACTOME THE NLRP3 INFLAMMASOME 129All SZGR 2.0 genes in this pathway
REACTOME INFLAMMASOMES 1712All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 4633All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481290All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351230All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL DN 6039All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320184All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460312All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306188All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244153All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269146All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN 7351All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR DN 12984All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177113All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 11784All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP 5540All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP 12171All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229142All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT1 TARGETS 109All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP 8858All SZGR 2.0 genes in this pathway
SCHAVOLT TARGETS OF TP53 AND TP63 1612All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
XU HGF TARGETS REPRESSED BY AKT1 DN 9558All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149101All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229137All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP 4738All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 8860All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT DN 2619All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261155All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 7652All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
ZEILSTRA CD44 TARGETS DN 75All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 7850All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 8356All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 11Q23 DELETION 2318All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA UP 6446All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 10267All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191131All SZGR 2.0 genes in this pathway
SCHURINGA STAT5A TARGETS DN 1810All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
HU GENOTOXIC DAMAGE 24HR 3522All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES 6844All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH UP 7456All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261166All SZGR 2.0 genes in this pathway
BILD SRC ONCOGENIC SIGNATURE 6238All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION UP 7440All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING DN 3624All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469239All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP 12692All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D DN 7834All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346192All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 13179All SZGR 2.0 genes in this pathway
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL UP 5838All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235144All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395249All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP 8961All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS DN 4223All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 4430All SZGR 2.0 genes in this pathway
GYORFFY DOXORUBICIN RESISTANCE 5634All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP 8363All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 DN 6938All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 9 7645All SZGR 2.0 genes in this pathway
NIELSEN GIST VS SYNOVIAL SARCOMA DN 2017All SZGR 2.0 genes in this pathway
NIELSEN SYNOVIAL SARCOMA DN 2013All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307182All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216130All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN 9974All SZGR 2.0 genes in this pathway