SZGR2

Summary ?

GeneID	834
Symbol	CASP1
Synonyms	ICE\|IL1BC\|P45
Description	caspase 1
Reference	MIM:147678\|HGNC:HGNC:1499\|Ensembl:ENSG00000137752\|HPRD:00977\|Vega:OTTHUMG00000048072
Gene type	protein-coding
Map location	11q23
Pascal p-value	0.046
DEG p-value	DEG:Sanders_2014:DS1_p=0.143:DS1_beta=0.049100:DS2_p=4.63e-02:DS2_beta=-0.097:DS2_FDR=1.89e-01
Fetal beta	-0.289

Gene in Data Sources

Gene set name	Method of gene set	Description
DEG:Sanders_2013	Microarray	Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
GSMA_I	Genome scan meta-analysis	Psr: 0.006
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 2.5585

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		12888622 \|15107016
GO:0004197	cysteine-type endopeptidase activity	IEA		-
GO:0004197	cysteine-type endopeptidase activity	TAS		10353249
GO:0008656	caspase activator activity	TAS		10799503
GO:0008233	peptidase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001666	response to hypoxia	IEA		-
GO:0006508	proteolysis	IDA		12888622
GO:0006508	proteolysis	IEA		-
GO:0008219	cell death	IEA		-
GO:0006917	induction of apoptosis	IEA		-
GO:0007165	signal transduction	TAS		1373520
GO:0042981	regulation of apoptosis	IEA		-
GO:0016485	protein processing	IEA		-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP		12761501
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005576	extracellular region	IEA		-
GO:0005622	intracellular	IEA		-
GO:0005634	nucleus	IDA		18029348
GO:0005730	nucleolus	IDA		18029348
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Androgen Receptor interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human androgen receptor and caspase 1 from an unspecified species.	BIND	9535906
ATN1	B37 \| D12S755E \| DRPLA \| NOD	atrophin 1	Atrophin-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human atrophin-1 and caspase 1 from an unspecified species.	BIND	9535906
ATXN3	AT3 \| ATX3 \| JOS \| MJD \| MJD1 \| SCA3	ataxin 3	Ataxin-3 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human ataxin-3 and caspase 1 from an unspecified species.	BIND	9535906
ATXN3	AT3 \| ATX3 \| JOS \| MJD \| MJD1 \| SCA3	ataxin 3	-	HPRD	9535906
BCAP31	6C6-AG \| BAP31 \| CDM \| DXS1357E	B-cell receptor-associated protein 31	-	HPRD,BioGRID	9334338
CARD16	COP \| COP1 \| PSEUDO-ICE	caspase recruitment domain family, member 16	-	HPRD	11432859 \|11536016
CARD17	INCA	caspase recruitment domain family, member 17	-	HPRD	15383541
CARD8	CARDINAL \| DACAR \| DKFZp779L0366 \| Dakar \| FLJ18119 \| FLJ18121 \| KIAA0955 \| MGC57162 \| NDPP \| NDPP1 \| TUCAN	caspase recruitment domain family, member 8	-	HPRD	11821383
CARD8	CARDINAL \| DACAR \| DKFZp779L0366 \| Dakar \| FLJ18119 \| FLJ18121 \| KIAA0955 \| MGC57162 \| NDPP \| NDPP1 \| TUCAN	caspase recruitment domain family, member 8	CARD-8 interacts with Casp-1	BIND	11821383
CASP1	ICE \| IL1BC \| P45	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	-	HPRD	9190289
CASP1	ICE \| IL1BC \| P45	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	Affinity Capture-Western	BioGRID	11432859
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8962078
CASP14	MGC119078 \| MGC119079	caspase 14, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	9792675
CASP4	ICE(rel)II \| ICEREL-II \| ICH-2 \| Mih1/TX \| TX	caspase 4, apoptosis-related cysteine peptidase	Reconstituted Complex	BioGRID	10477277
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8962078
COP	CLTO	clathrin-ordered protein	Affinity Capture-Western	BioGRID	11432859
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	11226410
HTT	HD \| IT15	huntingtin	Huntingtin interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human huntingtin and caspase 1 from an unspecified species.	BIND	9535906
HTT	HD \| IT15	huntingtin	-	HPRD	9535906
IL18	IGIF \| IL-18 \| IL-1g \| IL1F4 \| MGC12320	interleukin 18 (interferon-gamma-inducing factor)	Biochemical Activity	BioGRID	12096920
IL1F7	FIL1 \| FIL1(ZETA) \| FIL1Z \| IL-1F7 \| IL-1H4 \| IL-1RP1 \| IL1H4 \| IL1RP1	interleukin 1 family, member 7 (zeta)	Biochemical Activity	BioGRID	12096920
NA	NAC	neurocanthocytosis	Affinity Capture-Western	BioGRID	15107016
NFE2L2	NRF2	nuclear factor (erythroid-derived 2)-like 2	-	HPRD,BioGRID	10510468
NLRC4	CARD12 \| CLAN \| CLAN1 \| CLANA \| CLANB \| CLANC \| CLAND \| CLR2.1 \| IPAF	NLR family, CARD domain containing 4	-	HPRD,BioGRID	11472070
NLRC4	CARD12 \| CLAN \| CLAN1 \| CLANA \| CLANB \| CLANC \| CLAND \| CLR2.1 \| IPAF	NLR family, CARD domain containing 4	CARD12 (CLAN) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD12 and CASP1 from an unspecified species.	BIND	15107016
NLRC4	CARD12 \| CLAN \| CLAN1 \| CLANA \| CLANB \| CLANC \| CLAND \| CLR2.1 \| IPAF	NLR family, CARD domain containing 4	-	HPRD	11390368 \|11472070\|11472070
NLRP1	CARD7 \| CLR17.1 \| DEFCAP \| DEFCAP-L/S \| DKFZp586O1822 \| KIAA0926 \| NAC \| NALP1 \| PP1044 \| SLEV1 \| VAMAS1	NLR family, pyrin domain containing 1	NALP1 (NAC) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human NALP1 and CASP1 from an unspecified species.	BIND	15107016
NOD1	CARD4 \| CLR7.1 \| NLRC1	nucleotide-binding oligomerization domain containing 1	-	HPRD,BioGRID	10329646
NOD2	ACUG \| BLAU \| CARD15 \| CD \| CLR16.3 \| IBD1 \| NLRC2 \| NOD2B \| PSORAS1	nucleotide-binding oligomerization domain containing 2	Affinity Capture-Western	BioGRID	15107016
NOD2	ACUG \| BLAU \| CARD15 \| CD \| CLR16.3 \| IBD1 \| NLRC2 \| NOD2B \| PSORAS1	nucleotide-binding oligomerization domain containing 2	CARD15 (Nod2) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD15 and CASP1 from an unspecified species.	BIND	15107016
PARK2	AR-JP \| LPRS2 \| PDJ \| PRKN	Parkinson disease (autosomal recessive, juvenile) 2, parkin	-	HPRD	12692130
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	PS-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 1.	BIND	10069390
PYCARD	ASC \| CARD5 \| MGC10332 \| TMS \| TMS-1 \| TMS1	PYD and CARD domain containing	-	HPRD	11967258 \|12019269 \|12191486
RIPK2	CARD3 \| CARDIAK \| CCK \| GIG30 \| RICK \| RIP2	receptor-interacting serine-threonine kinase 2	-	HPRD,BioGRID	9705938

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY	62	47	All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY	56	44	All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS	53	43	All SZGR 2.0 genes in this pathway
BIOCARTA CASPASE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA D4GDI PATHWAY	13	8	All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY	34	28	All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY	40	34	All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY	52	39	All SZGR 2.0 genes in this pathway
PID ANTHRAX PATHWAY	17	15	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY	30	22	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME THE NLRP3 INFLAMMASOME	12	9	All SZGR 2.0 genes in this pathway
REACTOME INFLAMMASOMES	17	12	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	46	33	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN	267	178	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP	351	230	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL DN	60	39	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP	306	188	All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN	244	153	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP	269	146	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP	380	236	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN	73	51	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR DN	129	84	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP	177	113	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP	117	84	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP	55	40	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP	121	71	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN	229	142	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT1 TARGETS	10	9	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
SCHAVOLT TARGETS OF TP53 AND TP63	16	12	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
XU HGF TARGETS REPRESSED BY AKT1 DN	95	58	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1	229	137	All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP	47	38	All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS	88	60	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT DN	26	19	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN	261	155	All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN	76	52	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
ZEILSTRA CD44 TARGETS DN	7	5	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP	78	50	All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP	83	56	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN	366	238	All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 11Q23 DELETION	23	18	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA UP	64	46	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP	183	111	All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN	102	67	All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS	191	131	All SZGR 2.0 genes in this pathway
SCHURINGA STAT5A TARGETS DN	18	10	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR	544	307	All SZGR 2.0 genes in this pathway
HU GENOTOXIC DAMAGE 24HR	35	22	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN	298	200	All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES	68	44	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH UP	74	56	All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE	261	166	All SZGR 2.0 genes in this pathway
BILD SRC ONCOGENIC SIGNATURE	62	38	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION UP	74	40	All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING DN	36	24	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6	469	239	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP	476	285	All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP	126	92	All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP	259	185	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D DN	78	34	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP	131	79	All SZGR 2.0 genes in this pathway
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL UP	58	38	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN	315	201	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN	235	144	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP	408	276	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP	395	249	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN	442	275	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP	89	61	All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS DN	42	23	All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS	44	30	All SZGR 2.0 genes in this pathway
GYORFFY DOXORUBICIN RESISTANCE	56	34	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 DN	69	38	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 9	76	45	All SZGR 2.0 genes in this pathway
NIELSEN GIST VS SYNOVIAL SARCOMA DN	20	17	All SZGR 2.0 genes in this pathway
NIELSEN SYNOVIAL SARCOMA DN	20	13	All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP	307	182	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL	216	130	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP	397	206	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP	387	225	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN	99	74	All SZGR 2.0 genes in this pathway

Gene Page: CASP1