Summary ?
GeneID8358
SymbolHIST1H3B
SynonymsH3/l|H3FL
Descriptionhistone cluster 1, H3b
ReferenceMIM:602819|HGNC:HGNC:4776|Ensembl:ENSG00000274267|HPRD:11913|Vega:OTTHUMG00000014415
Gene typeprotein-coding
Map location6p22.2
Pascal p-value1.564E-11
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.033 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16869851chr420690056HIST1H3B83580.09trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MATR30.960.96
FYTTD10.960.97
RAB100.960.97
SRP720.950.95
KLHL90.950.96
ACTR30.950.96
CAND10.950.96
NRAS0.940.96
MARCH70.940.95
MAPK60.940.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.70-0.88
AC018755.7-0.70-0.78
MT-CO2-0.70-0.86
AF347015.33-0.69-0.84
HLA-F-0.69-0.78
AF347015.31-0.68-0.84
IFI27-0.68-0.85
AIFM3-0.67-0.77
TSC22D4-0.67-0.79
MT-CYB-0.67-0.82

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 140100All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 11681All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION 8964All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210127All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 12280All SZGR 2.0 genes in this pathway
REACTOME RNA POL I PROMOTER OPENING 6249All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132101All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION 8662All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS 8363All SZGR 2.0 genes in this pathway
TURASHVILI BREAST CARCINOMA DUCTAL VS LOBULAR UP 2114All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244153All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP 197110All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway