SZGR2

Summary ?

GeneID	836
Symbol	CASP3
Synonyms	CPP32\|CPP32B\|SCA-1
Description	caspase 3
Reference	MIM:600636\|HGNC:HGNC:1504\|Ensembl:ENSG00000164305\|HPRD:02799\|Vega:OTTHUMG00000133681
Gene type	protein-coding
Map location	4q34
Pascal p-value	0.101
Sherlock p-value	0.107
Fetal beta	2.137
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.3923

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg14471096	4	185570637	CCDC111;CASP3	1.58E-4	-0.389	0.032	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs16955618	chr15	29937543	CASP3	836		0.02		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SEPT2	0.75	0.70
ITGA6	0.75	0.69
CDC14A	0.74	0.71
HSDL2	0.74	0.70
SNX5	0.73	0.72
SUCLG2	0.72	0.73
PPAP2B	0.72	0.76
MSI2	0.72	0.66
PSAT1	0.72	0.77
PLOD2	0.71	0.69

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RTN4RL1	-0.37	-0.32
LRFN2	-0.36	-0.32
MPPED1	-0.35	-0.31
ARHGAP20	-0.35	-0.28
SLC26A4	-0.34	-0.34
RASGEF1C	-0.34	-0.29
AC093307.1	-0.34	-0.28
MYT1L	-0.34	-0.27
CECR6	-0.34	-0.29
MEF2C	-0.34	-0.30

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		9736630
GO:0004861	cyclin-dependent protein kinase inhibitor activity	IEA		-
GO:0004197	cysteine-type endopeptidase activity	IEA		-
GO:0004197	cysteine-type endopeptidase activity	TAS		10942389
GO:0008233	peptidase activity	IDA		9353287
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0051402	neuron apoptosis	IEA	neuron, axon, dendrite (GO term level: 7)	-
GO:0001836	release of cytochrome c from mitochondria	IEA		-
GO:0001782	B cell homeostasis	IEA		-
GO:0006309	DNA fragmentation during apoptosis	IEA		-
GO:0030264	nuclear fragmentation during apoptosis	IMP		11350920
GO:0008625	induction of apoptosis via death domain receptors	IEA		-
GO:0006508	proteolysis	IDA		12888622
GO:0006508	proteolysis	IEA		-
GO:0006917	induction of apoptosis	TAS		7983002
GO:0008631	induction of apoptosis by oxidative stress	IEA		-
GO:0009611	response to wounding	IEA		-
GO:0007507	heart development	IEA		-
GO:0007605	sensory perception of sound	IEA		-
GO:0009411	response to UV	IEA		-
GO:0006915	apoptosis	IEA		-
GO:0043066	negative regulation of apoptosis	IGI		9353287
GO:0030216	keratinocyte differentiation	IEA		-
GO:0030889	negative regulation of B cell proliferation	IEA		-
GO:0043029	T cell homeostasis	IEA		-
GO:0045165	cell fate commitment	IEA		-
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	IEA		-
GO:0046007	negative regulation of activated T cell proliferation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		8976194 \|9624143 \|10490026 \|10748026 \|10823823 \|11106668 \|11313965 \|11500511 \|11689006 \|16983089
GO:0005829	cytosol	IDA		17823127
GO:0005634	nucleus	IDA		18029348
GO:0005654	nucleoplasm	EXP		9108473
GO:0005730	nucleolus	IDA		18029348
GO:0005737	cytoplasm	IDA		18029348
GO:0005737	cytoplasm	IEA		-
GO:0005739	mitochondrion	IDA		18029348
GO:0005886	plasma membrane	EXP		11076937 \|16286477

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Androgen Receptor interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human androgen receptor and caspase 3 from an unspecified species.	BIND	9535906
ATN1	B37 \| D12S755E \| DRPLA \| NOD	atrophin 1	Atrophin-1 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human atrophin-1 and caspase 3 from an unspecified species.	BIND	9535906
ATXN3	AT3 \| ATX3 \| JOS \| MJD \| MJD1 \| SCA3	ataxin 3	Ataxin-3 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human ataxin-3 and caspase 3 from an unspecified species.	BIND	9535906
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD,BioGRID	11948397
BID	FP497 \| MGC15319 \| MGC42355	BH3 interacting domain death agonist	Biochemical Activity	BioGRID	11399776
BIRC2	API1 \| HIAP2 \| Hiap-2 \| MIHB \| RNF48 \| cIAP1	baculoviral IAP repeat-containing 2	-	HPRD,BioGRID	9384571
BIRC3	AIP1 \| API2 \| CIAP2 \| HAIP1 \| HIAP1 \| MALT2 \| MIHC \| RNF49	baculoviral IAP repeat-containing 3	cIAP2 exhibits E3 ubiquitin ligase activity towards Casp3.	BIND	10862606
BIRC3	AIP1 \| API2 \| CIAP2 \| HAIP1 \| HIAP1 \| MALT2 \| MIHC \| RNF49	baculoviral IAP repeat-containing 3	-	HPRD,BioGRID	9384571
BIRC5	API4 \| EPR-1	baculoviral IAP repeat-containing 5	-	HPRD,BioGRID	9850056
BIRC6	APOLLON \| BRUCE \| FLJ13726 \| FLJ13786 \| KIAA1289	baculoviral IAP repeat-containing 6	BRUCE interacts with Casp-3. This interaction was modeled on a demonstrated interaction between mouse BRUCE and human Casp-3.	BIND	15200957
BIRC7	KIAP \| LIVIN \| ML-IAP \| MLIAP \| RNF50	baculoviral IAP repeat-containing 7	-	HPRD,BioGRID	11024045
BLM	BS \| MGC126616 \| MGC131618 \| MGC131620 \| RECQ2 \| RECQL2 \| RECQL3	Bloom syndrome	Biochemical Activity	BioGRID	11470874
BMX	ETK \| PSCTK2 \| PSCTK3	BMX non-receptor tyrosine kinase	-	HPRD,BioGRID	11278797
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8962078
CASP2	CASP-2 \| ICH-1L \| ICH-1L/1S \| ICH1 \| NEDD2	caspase 2, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	11399776
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	11257232
CASP6	MCH2	caspase 6, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8900201
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8962078 \|11832478
CASP9	APAF-3 \| APAF3 \| CASPASE-9c \| ICE-LAP6 \| MCH6	caspase 9, apoptosis-related cysteine peptidase	-	HPRD	11230124
CDC2L2	CDC2L3 \| CDK11-p110 \| CDK11-p46 \| CDK11-p58 \| MGC131975 \| PITSLRE \| p58GTA	cell division cycle 2-like 2 (PITSLRE proteins)	-	HPRD	9632733
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	-	HPRD,BioGRID	9208847
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	MRIT-beta-1 interacts with YAMA. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and YAMA from an unspecified species.	BIND	9326610
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	MRIT-alpha-1 interacts with YAMA. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and YAMA from an unspecified species.	BIND	9326610
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD	9348292
CTTN	EMS1 \| FLJ34459	cortactin	Biochemical Activity	BioGRID	11689006
DBNL	ABP1 \| HIP-55 \| SH3P7	drebrin-like	Biochemical Activity	BioGRID	11689006
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	-	HPRD,BioGRID	11248093
DCTN1	DAP-150 \| DP-150 \| HMN7B \| P135	dynactin 1 (p150, glued homolog, Drosophila)	-	HPRD	11425872
DEDD	CASP8IP1 \| DEDD1 \| DEFT \| FLDED1 \| KE05	death effector domain containing	-	HPRD	12235123
DFFA	DFF-45 \| DFF1 \| ICAD	DNA fragmentation factor, 45kDa, alpha polypeptide	-	HPRD	11752060
EIF4B	EIF-4B \| PRO1843	eukaryotic translation initiation factor 4B	-	HPRD	11274152
GORASP1	FLJ23443 \| GOLPH5 \| GRASP65 \| MGC118894 \| MGC118897 \| P65	golgi reassembly stacking protein 1, 65kDa	-	HPRD,BioGRID	11815631
HCLS1	CTTNL \| HS1	hematopoietic cell-specific Lyn substrate 1	-	HPRD,BioGRID	11689006 \|11988074
HSPD1	CPN60 \| GROEL \| HSP60 \| HSP65 \| HuCHA60 \| SPG13	heat shock 60kDa protein 1 (chaperonin)	-	HPRD,BioGRID	10205158 \|10205159
HSPE1	CPN10 \| GROES \| HSP10	heat shock 10kDa protein 1 (chaperonin 10)	-	HPRD,BioGRID	10205158
HTT	HD \| IT15	huntingtin	Huntingtin interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human Huntingtin and caspase 3 from an unspecified species.	BIND	9535906
KCNIP3	CSEN \| DREAM \| KCHIP3 \| MGC18289	Kv channel interacting protein 3, calsenilin	-	HPRD	11278424
LMNB1	ADLD \| LMN \| LMN2 \| LMNB \| MGC111419	lamin B1	-	HPRD	11901153
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	Affinity Capture-Western	BioGRID	11002417
MCL1	BCL2L3 \| EAT \| MCL1L \| MCL1S \| MGC104264 \| MGC1839 \| TM	myeloid cell leukemia sequence 1 (BCL2-related)	Biochemical Activity	BioGRID	15637055
NDUFS1	CI-75Kd \| MGC26839 \| PRO1304	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	NDUFS1 interacts with caspase-3. This interaction was modeled on a demonstrated interaction between human NDUSF1 and caspase-3 from an unspecified source.	BIND	15186778
NEO1	DKFZp547A066 \| DKFZp547B146 \| HsT17534 \| NGN	neogenin homolog 1 (chicken)	Neogenin interacts with Caspase 3. This interaction was modelled on a demonstrated interaction between human Neogenin and Caspase 3 from an unspecified species.	BIND	15258591
NFE2L2	NRF2	nuclear factor (erythroid-derived 2)-like 2	-	HPRD,BioGRID	10510468
PARG	PARG99	poly (ADP-ribose) glycohydrolase	-	HPRD,BioGRID	11053413
PARP1	ADPRT \| ADPRT1 \| PARP \| PARP-1 \| PPOL \| pADPRT-1	poly (ADP-ribose) polymerase 1	PARP interacts with Caspase-3. This interaction was modeled on a demonstrated interaction between human PARP and caspase-3 from an unspecified source.	BIND	15186778
PDE10A	FLJ11894 \| FLJ25677 \| HSPDE10A	phosphodiesterase 10A	-	HPRD	11602184
PICALM	CALM \| CLTH \| LAP	phosphatidylinositol binding clathrin assembly protein	-	HPRD	10926122
PLEKHO1	CKIP-1 \| OC120	pleckstrin homology domain containing, family O member 1	CKIP-1 is cleaved by CASP3 during the initiation of apoptosis.	BIND	15706351
PPP3CA	CALN \| CALNA \| CALNA1 \| CCN1 \| CNA1 \| PPP2B	protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform	-	HPRD	11478781
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	PS1 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 3.	BIND	10069390
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	CASP3 (caspase-3) cleaves RB-1 (hRB) at the DEAD and DSID consensus sites to produce the p100, p68, p61 and p48 forms.	BIND	15735701
SARS2	FLJ20450 \| SARS \| SARSM \| SERS \| SYS \| SerRSmt \| mtSerRS	seryl-tRNA synthetase 2, mitochondrial	-	HPRD	11331419
SLK	KIAA0204 \| LOSK \| MGC133067 \| STK2 \| bA16H23.1 \| se20-9	STE20-like kinase (yeast)	-	HPRD	10611247
SREBF2	SREBP2 \| bHLHd2	sterol regulatory element binding transcription factor 2	-	HPRD,BioGRID	8605870
SRP72	-	signal recognition particle 72kDa	-	HPRD	9857079
TGM2	G-ALPHA-h \| GNAH \| TG2 \| TGC	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	-	HPRD	10556977
TNS4	CTEN \| FLJ14950 \| PP14434	tensin 4	Caspase-3 interacts with and cleaves cten.	BIND	15806167
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	-	HPRD	11098060
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	-	HPRD,BioGRID	11261798
USO1	P115 \| TAP \| VDP	USO1 homolog, vesicle docking protein (yeast)	-	HPRD,BioGRID	12438416
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	-	HPRD	9230442 \|11447297 \|11927604
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	XIAP interacts with Casp-3.	BIND	15200957
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	Affinity Capture-Western Co-crystal Structure in vitro in vivo Reconstituted Complex	BioGRID	9230442 \|9384571 \|11257232 \|11447297 \|11927604
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	Caspase-3 interacts with XIAP.	BIND	15650747

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG P53 SIGNALING PATHWAY	69	45	All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS	88	62	All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY	137	92	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG PARKINSONS DISEASE	133	78	All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS	53	43	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION	68	44	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
BIOCARTA DNAFRAGMENT PATHWAY	10	6	All SZGR 2.0 genes in this pathway
BIOCARTA CHEMICAL PATHWAY	22	15	All SZGR 2.0 genes in this pathway
BIOCARTA BCELLSURVIVAL PATHWAY	16	10	All SZGR 2.0 genes in this pathway
BIOCARTA CASPASE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA D4GDI PATHWAY	13	8	All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY	30	22	All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY	33	24	All SZGR 2.0 genes in this pathway
BIOCARTA MITOCHONDRIA PATHWAY	21	15	All SZGR 2.0 genes in this pathway
BIOCARTA HSP27 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
BIOCARTA TNFR1 PATHWAY	29	21	All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY	29	20	All SZGR 2.0 genes in this pathway
SA CASPASE CASCADE	19	13	All SZGR 2.0 genes in this pathway
ST GRANULE CELL SURVIVAL PATHWAY	27	23	All SZGR 2.0 genes in this pathway
SA FAS SIGNALING	9	5	All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY	65	54	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID NFAT TFPATHWAY	47	39	All SZGR 2.0 genes in this pathway
PID FAS PATHWAY	38	29	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY	48	38	All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY	69	51	All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY	35	26	All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY	52	39	All SZGR 2.0 genes in this pathway
PID SYNDECAN 2 PATHWAY	33	27	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	40	26	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY HIPPO	22	15	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	13	10	All SZGR 2.0 genes in this pathway
REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	13	11	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	12	6	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF APOPTOSIS	58	34	All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	60	43	All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	81	61	All SZGR 2.0 genes in this pathway
REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	10	5	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	30	21	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE	54	37	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP	136	80	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP	456	228	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT UP	87	45	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP	117	84	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 UP	58	39	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
MARKS HDAC TARGETS UP	23	15	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 XPCS UP	28	16	All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT1 TARGETS	10	9	All SZGR 2.0 genes in this pathway
GALLUZZI PERMEABILIZE MITOCHONDRIA	43	31	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP	309	199	All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP	108	69	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN	103	71	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
COLLIS PRKDC REGULATORS	15	10	All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP	52	40	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN	366	238	All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA DN	19	14	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN	228	146	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT	51	41	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN	60	42	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D1	18	13	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN	96	71	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5	482	296	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3	160	103	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN	108	64	All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP	223	132	All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP	259	185	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION C	69	49	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN	245	150	All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES	148	83	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP	163	102	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 MULTIPLE MYELOMA PROGRAM	36	25	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE	101	76	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE	67	51	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE	81	66	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED DENDRITIC CELL	65	49	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2	182	102	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
ABDELMOHSEN ELAVL4 TARGETS	16	13	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B	517	302	All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE	151	86	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	153	160	1A,m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-138	759	765	1A	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-30-5p	1188	1194	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CASP3