Summary ?
GeneID838
SymbolCASP5
SynonymsICE(rel)III|ICEREL-III|ICH-3
Descriptioncaspase 5
ReferenceMIM:602665|HGNC:HGNC:1506|Ensembl:ENSG00000137757|HPRD:04048|Vega:OTTHUMG00000048073
Gene typeprotein-coding
Map location11q22.2-q22.3
Pascal p-value0.026

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.006 
ExpressionMeta-analysis of gene expressionP value: 1.724 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PYCR20.760.77
FAM73B0.750.76
SRPR0.750.77
ABHD120.750.77
PNPO0.750.78
TMEM2140.740.74
CRELD10.740.76
RHPN10.740.78
PIGV0.730.74
ICMT0.730.73
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FAM159B-0.42-0.50
DOK5-0.37-0.11
AF347015.21-0.37-0.10
FABP7-0.37-0.45
RP9P-0.36-0.37
RBMX2-0.36-0.39
SATB2-0.36-0.10
AF347015.18-0.35-0.12
AC010300.1-0.35-0.27
AC087071.1-0.34-0.26

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI17418785 
GO:0004197cysteine-type endopeptidase activityIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006508proteolysisTAS7797592 
GO:0042981regulation of apoptosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 6247All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER 4930All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216130All SZGR 2.0 genes in this pathway