Gene Page: PIP4K2B

Summary ?
GeneID8396
SymbolPIP4K2B
SynonymsPI5P4KB|PIP5K2B|PIP5KIIB|PIP5KIIbeta|PIP5P4KB
Descriptionphosphatidylinositol-5-phosphate 4-kinase, type II, beta
ReferenceMIM:603261|HGNC:HGNC:8998|Ensembl:ENSG00000276293|HPRD:04463|Vega:OTTHUMG00000188504
Gene typeprotein-coding
Map location17q12
Pascal p-value1.269E-4
Sherlock p-value0.985
Fetal beta-0.387
DMG1 (# studies)
eGeneMyers' cis & trans
Meta
SupportCELL METABOLISM
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg181235961736956264PIP4K2B3.8E-8-0.0111.09E-5DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17435426chr118509215PIP4K2B83960.06trans
rs17488361chr118510984PIP4K2B83960.11trans
rs3893319chr124506048PIP4K2B83960.09trans
rs12748731chr130301307PIP4K2B83960.13trans
snp_a-42182180PIP4K2B83960.01trans
rs17449278chr157437250PIP4K2B83960.03trans
rs6701615chr157466884PIP4K2B83960.06trans
rs17416642chr157471620PIP4K2B83960.01trans
rs17598972chr176487107PIP4K2B83960.03trans
snp_a-42002380PIP4K2B83960trans
rs6662186chr1165264732PIP4K2B83960.15trans
rs2025890chr1167014086PIP4K2B83960.11trans
rs12063716chr1175760751PIP4K2B83960.02trans
rs10913081chr1175765788PIP4K2B83960.02trans
rs16849522chr1176016131PIP4K2B83968.918E-6trans
rs16857239chr1181377528PIP4K2B83960.18trans
rs4120839chr1181816818PIP4K2B83960.03trans
snp_a-42318340PIP4K2B83969.432E-4trans
rs6682594chr1241105470PIP4K2B83960.08trans
rs2500493chr1244253768PIP4K2B83960.04trans
rs2500495chr1244253848PIP4K2B83960.03trans
rs2454232chr1244257326PIP4K2B83960.04trans
rs16982026chr220994717PIP4K2B83960.09trans
rs4971530chr221044591PIP4K2B83960.02trans
rs13424969chr240569887PIP4K2B83960trans
rs7581498chr265860797PIP4K2B83960.06trans
rs10865470chr284105958PIP4K2B83960.06trans
rs904441chr289598360PIP4K2B83960.13trans
rs17353243chr2100819383PIP4K2B83960.03trans
rs6754538chr2113777392PIP4K2B83960.14trans
rs1562303chr2113782391PIP4K2B83960.1trans
rs6708535chr2113833838PIP4K2B83960.12trans
rs11122818chr2121568890PIP4K2B83960trans
rs1809024chr2121570087PIP4K2B83960trans
rs7591937chr2121590686PIP4K2B83960.01trans
rs16847588chr2133847479PIP4K2B83960.08trans
rs10928642chr2138805485PIP4K2B83960.11trans
rs17477437chr2141088964PIP4K2B83960.05trans
rs16843881chr2141144193PIP4K2B83960.15trans
rs222827chr2146878441PIP4K2B83960.02trans
rs222826chr2146878531PIP4K2B83960trans
rs10168656chr2146923444PIP4K2B83960trans
rs7608936chr2146933933PIP4K2B83960trans
rs2572085chr2146961837PIP4K2B83968.515E-4trans
rs987214chr2147004926PIP4K2B83960trans
snp_a-18715880PIP4K2B83960.14trans
snp_a-19221190PIP4K2B83960trans
rs12612749chr2217303634PIP4K2B83960trans
rs3770480chr2217304239PIP4K2B83960trans
rs560025chr2217307571PIP4K2B83960.05trans
rs6714334chr2231841525PIP4K2B83960.11trans
rs6776786chr36424578PIP4K2B83960.03trans
rs1356268chr37021094PIP4K2B83960.02trans
rs9813119chr345230566PIP4K2B83960trans
rs6807877chr360531241PIP4K2B83960.15trans
rs2885872chr367421487PIP4K2B83962.965E-5trans
rs2363714chr367421845PIP4K2B83961.788E-4trans
rs16837171chr3125871772PIP4K2B83960.05trans
rs4276141chr3126832798PIP4K2B83960.01trans
rs11569214chr3141711503PIP4K2B83960.14trans
rs6773121chr3169662410PIP4K2B83960.12trans
rs1498657chr3192812472PIP4K2B83968.754E-5trans
rs13127396chr411397471PIP4K2B83960.01trans
rs11934067chr496441555PIP4K2B83960.1trans
rs4699680chr499759131PIP4K2B83960.01trans
rs10021819chr4106895613PIP4K2B83960trans
rs17038770chr4109200359PIP4K2B83960.01trans
rs17062227chr4176828538PIP4K2B83960.02trans
rs12505648chr4189724063PIP4K2B83960.1trans
rs268474chr59492721PIP4K2B83960.02trans
rs13357458chr510935006PIP4K2B83960.01trans
rs931809chr531909662PIP4K2B83960.04trans
rs749169chr577161057PIP4K2B83960.06trans
rs1862599chr582095088PIP4K2B83960.01trans
rs17431689chr5115778851PIP4K2B83960.1trans
rs1846664chr5157154517PIP4K2B83960.15trans
rs936813chr5178895398PIP4K2B83960.02trans
rs6920921chr68884160PIP4K2B83966.868E-5trans
rs498753chr676346145PIP4K2B83960.07trans
rs16886827chr676408984PIP4K2B83960.07trans
rs12215385chr6110053455PIP4K2B83960.18trans
rs2295837chr6110064927PIP4K2B83960.18trans
rs752292chr6126129255PIP4K2B83960.06trans
rs9497950chr6148493689PIP4K2B83960.14trans
rs2106899chr719908667PIP4K2B83960.01trans
rs17172130chr742906658PIP4K2B83960.06trans
rs2268315chr744705292PIP4K2B83960.15trans
rs740040chr744713690PIP4K2B83960.18trans
rs868269chr776007808PIP4K2B83960.03trans
rs7798366chr7112582172PIP4K2B83960.15trans
rs7791922chr7125130234PIP4K2B83960.1trans
rs2524879chr7125222439PIP4K2B83960.09trans
rs2524880chr7125222519PIP4K2B83960.09trans
rs7779787chr7147368735PIP4K2B83960.01trans
rs3008254chr8227580PIP4K2B83960.05trans
rs7818615chr81151433PIP4K2B83960.03trans
rs352768chr815644926PIP4K2B83960.08trans
rs2461327chr838373923PIP4K2B83960.01trans
rs6997050chr854780173PIP4K2B83960.01trans
rs16925577chr97204761PIP4K2B83960.09trans
rs7048998chr97382194PIP4K2B83960.08trans
rs10816182chr99795184PIP4K2B83960.02trans
rs13300718chr913595328PIP4K2B83960.03trans
rs6475123chr917244615PIP4K2B83960.05trans
rs3808782chr917340863PIP4K2B83960trans
rs4554574chr917379848PIP4K2B83960.01trans
rs2780203chr917432631PIP4K2B83960.12trans
rs2254722chr917485787PIP4K2B83960.03trans
rs17835770chr927484574PIP4K2B83960.02trans
rs7047415chr998541231PIP4K2B83960.12trans
rs16910240chr998544974PIP4K2B83960.1trans
rs10986330chr9127152781PIP4K2B83960.15trans
rs7025082chr9137502994PIP4K2B83960.02trans
rs11103433chr9137510143PIP4K2B83960.02trans
rs4397792chr1060794634PIP4K2B83965.434E-4trans
rs7092935chr1060804206PIP4K2B83960.03trans
rs7914543chr1060815805PIP4K2B83960.02trans
rs16913019chr1060821455PIP4K2B83962.805E-7trans
rs16913020chr1060821630PIP4K2B83960trans
rs16913024chr1060822278PIP4K2B83961.624E-5trans
rs10491010chr1060826510PIP4K2B83960.01trans
rs7897406chr1060829143PIP4K2B83968.532E-4trans
rs10159472chr1060831660PIP4K2B83960trans
rs7911331chr1060832581PIP4K2B83960.13trans
rs7911611chr1060832790PIP4K2B83960.01trans
rs7084763chr1060836132PIP4K2B83960.01trans
rs16913076chr1060839930PIP4K2B83969.331E-4trans
rs12245159chr1060896208PIP4K2B83962.805E-7trans
rs16913289chr1060956903PIP4K2B83961.536E-4trans
rs11006425chr1061041181PIP4K2B83961.536E-4trans
rs16914850chr1063412638PIP4K2B83960.03trans
rs10997325chr1068469236PIP4K2B83960trans
rs3750776chr1071716077PIP4K2B83960.08trans
rs17712988chr1083589133PIP4K2B83960.08trans
rs1326830chr1096495792PIP4K2B83960.1trans
rs1413714chr10106405934PIP4K2B83960trans
rs12271990chr1126001260PIP4K2B83960.05trans
rs12272179chr1126001407PIP4K2B83960.02trans
rs17136959chr1178373036PIP4K2B83960.09trans
rs4944213chr1178395188PIP4K2B83960.09trans
rs10501658chr1187788891PIP4K2B83969.159E-5trans
rs2220303chr1187791435PIP4K2B83960trans
rs10831205chr1187801856PIP4K2B83960.01trans
rs497776chr1195957663PIP4K2B83960.05trans
rs17126243chr11122049674PIP4K2B83960.01trans
rs2370698chr11122059979PIP4K2B83963.225E-6trans
rs17174558chr1232994828PIP4K2B83960.04trans
rs4768365chr1242161392PIP4K2B83960.04trans
rs7299055chr1242161661PIP4K2B83960.02trans
rs11170391chr1253455852PIP4K2B83960trans
rs2293060chr1253459001PIP4K2B83960.01trans
rs2293059chr1253459100PIP4K2B83961.785E-4trans
rs11170394chr1253463971PIP4K2B83960.08trans
rs7971816chr1295217854PIP4K2B83960trans
rs6538558chr1295238216PIP4K2B83960trans
rs10859776chr1295259192PIP4K2B83960.01trans
rs7309593chr12114257207PIP4K2B83960.07trans
rs11068670chr12118182168PIP4K2B83960.11trans
rs10850897chr12118196074PIP4K2B83960.11trans
rs11059871chr12129234810PIP4K2B83960.18trans
rs470444chr12129377353PIP4K2B83969.032E-4trans
rs9570793chr1331749362PIP4K2B83960.02trans
rs17295858chr1345696071PIP4K2B83960.03trans
rs9596110chr1350039507PIP4K2B83960.02trans
rs9569467chr1357024913PIP4K2B83961.422E-15trans
rs9538387chr1359897244PIP4K2B83961.046E-4trans
rs7996910chr1372723313PIP4K2B83963.509E-7trans
rs4575403chr1393430256PIP4K2B83960.17trans
rs9561208chr1393603786PIP4K2B83960.01trans
rs3955211chr13114914803PIP4K2B83960.01trans
rs453784chr13114928103PIP4K2B83960.06trans
rs7142052chr1433475597PIP4K2B83960.03trans
rs4982031chr1433478164PIP4K2B83960.02trans
rs10483422chr1433478504PIP4K2B83960.02trans
rs6572777chr1452051741PIP4K2B83960.01trans
rs1958657chr1454262933PIP4K2B83963.883E-4trans
rs12589216chr1454263431PIP4K2B83963.883E-4trans
rs17126953chr1454277988PIP4K2B83963.883E-4trans
rs10498462chr1454281468PIP4K2B83960.01trans
rs8005401chr1456297368PIP4K2B83960.05trans
rs17093231chr1457848289PIP4K2B83961.259E-4trans
rs7143284chr1458320614PIP4K2B83960.01trans
rs927248chr1458321206PIP4K2B83960.01trans
rs17836777chr1467948747PIP4K2B83960.01trans
rs2402136chr1492876464PIP4K2B83960trans
rs2402137chr1492876510PIP4K2B83960trans
rs11844578chr1498752139PIP4K2B83960.14trans
rs8025963chr1523705543PIP4K2B83960.04trans
rs2114484chr1526754275PIP4K2B83960.08trans
rs7176970chr1529443313PIP4K2B83960.19trans
rs17647707chr1551568019PIP4K2B83960.15trans
rs8023670chr1558041821PIP4K2B83960.15trans
rs1562404chr1576129641PIP4K2B83960.15trans
rs4595769chr1587987591PIP4K2B83964.865E-5trans
rs6497089chr1594163348PIP4K2B83960.06trans
rs1036529chr1597071598PIP4K2B83960.14trans
rs9934288chr16716286PIP4K2B83960.05trans
rs1469111chr1622171661PIP4K2B83960trans
rs735701chr176194436PIP4K2B83960.01trans
rs16961516chr1717208231PIP4K2B83960.2trans
rs16971746chr1734292938PIP4K2B83960.18trans
rs16941771chr1745340356PIP4K2B83960.1trans
rs12051795chr1745413383PIP4K2B83960trans
rs11871031chr1745416537PIP4K2B83960trans
rs7217610chr1749961963PIP4K2B83960.01trans
rs9675273chr1749979364PIP4K2B83960.04trans
rs9675183chr1749982512PIP4K2B83960.01trans
rs15944chr1755198247PIP4K2B83963.447E-8trans
rs8078002chr1765230990PIP4K2B83960.01trans
rs9911952chr1765256893PIP4K2B83960.01trans
rs4510078chr1780205712PIP4K2B83960.14trans
rs3016594chr183000856PIP4K2B83960.05trans
rs500876chr184388536PIP4K2B83960trans
rs2155765chr1825705138PIP4K2B83960.17trans
rs10853423chr1830409843PIP4K2B83960.01trans
rs1941282chr1830410688PIP4K2B83960.01trans
rs1941283chr1830410848PIP4K2B83960.01trans
rs1893246chr1830414983PIP4K2B83960.01trans
rs4799668chr1830416899PIP4K2B83960.01trans
rs948373chr1830428048PIP4K2B83960.01trans
rs16966921chr1833205896PIP4K2B83960.08trans
rs16966973chr1833236066PIP4K2B83960.19trans
rs16967009chr1833270246PIP4K2B83960.07trans
rs16967010chr1833270294PIP4K2B83960.08trans
rs8097644chr1857866383PIP4K2B83960.01trans
rs10513931chr1861569462PIP4K2B83960.01trans
rs17079940chr1866612584PIP4K2B83960.17trans
rs17080874chr1867015071PIP4K2B83963.691E-5trans
rs11875354chr1867017884PIP4K2B83963.691E-5trans
rs17082636chr1868098567PIP4K2B83960trans
rs1821449chr1873285949PIP4K2B83960trans
rs216279chr193005230PIP4K2B83960.04trans
rs2285669chr1958119763PIP4K2B83960.11trans
rs2885007chr1958134271PIP4K2B83960.07trans
rs3790267chr2019565692PIP4K2B83960.03trans
rs6515028chr2019576068PIP4K2B83967.203E-4trans
rs6081676chr2019583373PIP4K2B83960.17trans
rs4141780chr2040297792PIP4K2B83960trans
rs1523533chr2051329866PIP4K2B83960.02trans
rs2226440chr2118066174PIP4K2B83965.695E-4trans
rs4818674chr2123697152PIP4K2B83965.736E-5trans
rs9968025chr2232321588PIP4K2B83969.646E-4trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG INOSITOL PHOSPHATE METABOLISM 5442All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 7656All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 3123All SZGR 2.0 genes in this pathway
REACTOME PI METABOLISM 4834All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
MIDORIKAWA AMPLIFIED IN LIVER CANCER 5538All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380213All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE NORMAL DN 3327All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON 13378All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214133All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249170All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6 153112All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 10968All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 VIA ERCC6 UP 4030All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221120All SZGR 2.0 genes in this pathway