Summary ?
GeneID8403
SymbolSOX14
SynonymsSOX28
DescriptionSRY-box 14
ReferenceMIM:604747|HGNC:HGNC:11193|Ensembl:ENSG00000168875|HPRD:16067|Vega:OTTHUMG00000159757
Gene typeprotein-coding
Map location3q22-q23
Pascal p-value0.396
Fetal beta-0.152

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 0
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TMEFF10.860.86
GSPT20.860.85
GTF2E10.850.84
BFAR0.850.85
METAP20.850.83
C9orf300.850.86
TARS0.850.84
FAF10.850.86
MSH20.840.86
THUMPD30.840.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.69-0.79
AF347015.27-0.69-0.79
AF347015.31-0.69-0.79
AF347015.33-0.69-0.79
AF347015.8-0.68-0.79
MT-CYB-0.67-0.77
AF347015.15-0.67-0.79
AF347015.2-0.66-0.78
HLA-F-0.65-0.70
TINAGL1-0.64-0.70

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityNAS-
GO:0003700transcription factor activityTAS9925951 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)9925951 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006355regulation of transcription, DNA-dependentNAS-
GO:0006350transcriptionIEA-
GO:0006325establishment or maintenance of chromatin architectureNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000785chromatinIEA-
GO:0005634nucleusIEA-
GO:0005634nucleusNAS-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
GAZIN EPIGENETIC SILENCING BY KRAS 2616All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246152All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway