SZGR2

Summary ?

GeneID	841
Symbol	CASP8
Synonyms	ALPS2B\|CAP4\|Casp-8\|FLICE\|MACH\|MCH5
Description	caspase 8
Reference	MIM:601763\|HGNC:HGNC:1509\|Ensembl:ENSG00000064012\|HPRD:03459\|Vega:OTTHUMG00000132821
Gene type	protein-coding
Map location	2q33-q34
Pascal p-value	0.033
Fetal beta	0.114
eGene	Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	TSS distance	eQTL type
rs59308963	2	202123479	CASP8	ENSG00000064012.17	3.101E-8	25313	gtex_brain_ba24
rs55971105	2	202123717	CASP8	ENSG00000064012.17	3.137E-6	25551	gtex_brain_ba24
rs6735656	2	202124502	CASP8	ENSG00000064012.17	3.32E-8	26336	gtex_brain_ba24
rs6754084	2	202124997	CASP8	ENSG00000064012.17	3.111E-8	26831	gtex_brain_ba24
rs1861270	2	202126615	CASP8	ENSG00000064012.17	3.111E-8	28449	gtex_brain_ba24
rs6435074	2	202127947	CASP8	ENSG00000064012.17	3.105E-8	29781	gtex_brain_ba24
rs2349070	2	202130308	CASP8	ENSG00000064012.17	3.099E-8	32142	gtex_brain_ba24
rs10931936	2	202143928	CASP8	ENSG00000064012.17	8.612E-8	45762	gtex_brain_ba24
rs3769818	2	202151163	CASP8	ENSG00000064012.17	8.612E-8	52997	gtex_brain_ba24
rs700635	2	202153225	CASP8	ENSG00000064012.17	8.612E-8	55059	gtex_brain_ba24
rs6714430	2	202153684	CASP8	ENSG00000064012.17	8.612E-8	55518	gtex_brain_ba24
rs6743068	2	202153920	CASP8	ENSG00000064012.17	8.612E-8	55754	gtex_brain_ba24
rs10200279	2	202170655	CASP8	ENSG00000064012.17	8.713E-8	72489	gtex_brain_ba24
rs6719014	2	202176024	CASP8	ENSG00000064012.17	8.982E-8	77858	gtex_brain_ba24
rs7582362	2	202176294	CASP8	ENSG00000064012.17	8.99E-8	78128	gtex_brain_ba24
rs6731171	2	202179011	CASP8	ENSG00000064012.17	1.381E-6	80845	gtex_brain_ba24
rs1830298	2	202181247	CASP8	ENSG00000064012.17	2.584E-7	83081	gtex_brain_ba24
rs9677180	2	202184331	CASP8	ENSG00000064012.17	9.479E-8	86165	gtex_brain_ba24
rs2349073	2	202186986	CASP8	ENSG00000064012.17	1.36E-7	88820	gtex_brain_ba24
rs10197246	2	202204741	CASP8	ENSG00000064012.17	6.761E-7	106575	gtex_brain_ba24
rs2110687	2	202223403	CASP8	ENSG00000064012.17	2.188E-6	125237	gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
NEXN	0.87	0.51
CARD11	0.86	0.58
FAM19A4	0.84	0.64
SUSD2	0.83	0.75
SMPX	0.83	0.52
DPYS	0.82	0.45
RGS16	0.81	0.18
AL133445.2	0.80	0.34
FAM20A	0.80	0.02
ABHD12B	0.79	0.71

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
PLEKHO1	-0.34	-0.67
NR2C2AP	-0.32	-0.67
SHF	-0.30	-0.62
MPP3	-0.30	-0.60
C19orf57	-0.30	-0.59
TUBB2B	-0.29	-0.58
SAMD14	-0.29	-0.62
KIAA1949	-0.29	-0.56
MARCKSL1	-0.29	-0.59
STAG3	-0.29	-0.57

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APAF1	CED4 \| DKFZp781B1145	apoptotic peptidase activating factor 1	-	HPRD,BioGRID	9539746
APP	AAA \| ABETA \| ABPP \| AD1 \| APPI \| CTFgamma \| CVAP \| PN2	amyloid beta (A4) precursor protein	-	HPRD	10911620
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Androgen Receptor interacts with caspase 8.	BIND	9535906
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	Co-purification	BioGRID	15659383
ATN1	B37 \| D12S755E \| DRPLA \| NOD	atrophin 1	Atrophin-1 interacts with caspase 8.	BIND	9535906
BCAP31	6C6-AG \| BAP31 \| CDM \| DXS1357E	B-cell receptor-associated protein 31	-	HPRD,BioGRID	9334338
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD,BioGRID	11406564
BCL2L1	BCL-XL/S \| BCL2L \| BCLX \| Bcl-X \| DKFZp781P2092 \| bcl-xL \| bcl-xS	BCL2-like 1	-	HPRD	11733517
BCL2L1	BCL-XL/S \| BCL2L \| BCLX \| Bcl-X \| DKFZp781P2092 \| bcl-xL \| bcl-xS	BCL2-like 1	Phenotypic Suppression	BioGRID	11832478
BFAR	BAR \| RNF47	bifunctional apoptosis regulator	-	HPRD	10716992
BID	FP497 \| MGC15319 \| MGC42355	BH3 interacting domain death agonist	Biochemical Activity Co-purification	BioGRID	11832478 \|15659383
BIRC2	API1 \| HIAP2 \| Hiap-2 \| MIHB \| RNF48 \| cIAP1	baculoviral IAP repeat-containing 2	Affinity Capture-Western	BioGRID	12887920
CASP1	ICE \| IL1BC \| P45	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	Biochemical Activity	BioGRID	8962078
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	Affinity Capture-Western Biochemical Activity Co-purification	BioGRID	8962078 \|11832478 \|12887920 \|15659383
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	-	HPRD	9325248
CASP14	MGC119078 \| MGC119079	caspase 14, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	9792675
CASP2	CASP-2 \| ICH-1L \| ICH-1L/1S \| ICH1 \| NEDD2	caspase 2, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8962078 \|11832478
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8962078 \|11832478
CASP4	ICE(rel)II \| ICEREL-II \| ICH-2 \| Mih1/TX \| TX	caspase 4, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8962078
CASP6	MCH2	caspase 6, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	12232792
CASP7	CMH-1 \| ICE-LAP3 \| MCH3	caspase 7, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8962078 \|11832478
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	10964557
CASP8AP2	CED-4 \| FLASH \| FLJ11208 \| KIAA1315 \| RIP25	caspase 8 associated protein 2	-	HPRD,BioGRID	10235259 \|11340079
CASP9	APAF-3 \| APAF3 \| CASPASE-9c \| ICE-LAP6 \| MCH6	caspase 9, apoptosis-related cysteine peptidase	Biochemical Activity Phenotypic Suppression	BioGRID	8962078 \|11832478
CDC2L2	CDC2L3 \| CDK11-p110 \| CDK11-p46 \| CDK11-p58 \| MGC131975 \| PITSLRE \| p58GTA	cell division cycle 2-like 2 (PITSLRE proteins)	-	HPRD	9632733
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	-	HPRD	12189238
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	MRIT-beta-1 interacts with FLICE. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and FLICE from an unspecified species.	BIND	9326610
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9208847 \|9228018 \|9289491 \|9326610 \|11741985 \|12215447 \|12887920
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	-	HPRD	9208847 \|9289491 \|12215447
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	MRIT-alpha-1 interacts with FLICE. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and FLICE from an unspecified species.	BIND	9326610
CHD3	Mi-2a \| Mi2-ALPHA \| ZFH	chromodomain helicase DNA binding protein 3	Two-hybrid	BioGRID	16169070
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	-	HPRD,BioGRID	11002417
CRADD	MGC9163 \| RAIDD	CASP2 and RIPK1 domain containing adaptor with death domain	-	HPRD	11002417
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD	12189238
DEDD	CASP8IP1 \| DEDD1 \| DEFT \| FLDED1 \| KE05	death effector domain containing	-	HPRD,BioGRID	12527898
DEDD2	FLAME-3	death effector domain containing 2	-	HPRD,BioGRID	11965497 \|12527898\|12527898
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	Co-purification	BioGRID	15659383
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	CASP8 (caspase-8) interacts with FADD.	BIND	15782135
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	-	HPRD,BioGRID	12107169
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	-	HPRD	11717445 \|12107169\|12107169
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	caspase-8 interacts with FADD.	BIND	12220669
FAF1	CGI-03 \| FLJ37524 \| HFAF1s \| UBXD12 \| UBXN3A \| hFAF1	Fas (TNFRSF6) associated factor 1	-	HPRD	12702723
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	-	HPRD	11101867
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	Affinity Capture-Western Co-purification	BioGRID	9208847 \|9325248 \|15659383
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	Affinity Capture-Western Co-purification	BioGRID	12887920 \|15659383
HIP1	ILWEQ \| MGC126506	huntingtin interacting protein 1	-	HPRD,BioGRID	11788820
HTT	HD \| IT15	huntingtin	Htt interacts with caspase 8.	BIND	14713958
IFT57	ESRRBL1 \| FLJ10147 \| HIPPI \| MHS4R2	intraflagellar transport 57 homolog (Chlamydomonas)	-	HPRD,BioGRID	11788820
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	-	HPRD,BioGRID	11002417
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	-	HPRD,BioGRID	11002417
MAP4K4	FLH21957 \| FLJ10410 \| FLJ20373 \| FLJ90111 \| HGK \| KIAA0687 \| NIK	mitogen-activated protein kinase kinase kinase kinase 4	-	HPRD	11002417
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	Co-purification	BioGRID	15659383
MSN	-	moesin	Co-purification	BioGRID	15659383
NOD1	CARD4 \| CLR7.1 \| NLRC1	nucleotide-binding oligomerization domain containing 1	-	HPRD,BioGRID	10329646
NOL3	ARC \| CARD2 \| MYC \| MYP \| NOP \| NOP30	nucleolar protein 3 (apoptosis repressor with CARD domain)	ARC interacts with procaspase-8.	BIND	15383280
NOL3	ARC \| CARD2 \| MYC \| MYP \| NOP \| NOP30	nucleolar protein 3 (apoptosis repressor with CARD domain)	-	HPRD,BioGRID	9560245
NR1H4	BAR \| FXR \| HRR-1 \| HRR1 \| MGC163445 \| RIP14	nuclear receptor subfamily 1, group H, member 4	-	HPRD,BioGRID	11733517
PEA15	HMAT1 \| HUMMAT1H \| MAT1 \| MAT1H \| PEA-15 \| PED	phosphoprotein enriched in astrocytes 15	-	HPRD,BioGRID	10442631 \|10493725
PIAS1	DDXBP1 \| GBP \| GU/RH-II \| MGC141878 \| MGC141879 \| ZMIZ3	protein inhibitor of activated STAT, 1	CASP8 (caspase-8) interacts with PIAS-1.	BIND	15782135
PICALM	CALM \| CLTH \| LAP	phosphatidylinositol binding clathrin assembly protein	-	HPRD	10926122
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	Affinity Capture-Western	BioGRID	12887920
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	CASP8 (caspase-8) cleaves RB-1 (hRB) into the p68 form and to a lesser extent the p61 form.	BIND	15735701
RHOA	ARH12 \| ARHA \| RHO12 \| RHOH12	ras homolog gene family, member A	Co-purification	BioGRID	15659383
RIPK1	FLJ39204 \| RIP \| RIP1	receptor (TNFRSF)-interacting serine-threonine kinase 1	-	HPRD,BioGRID	11002417
RIPK2	CARD3 \| CARDIAK \| CCK \| GIG30 \| RICK \| RIP2	receptor-interacting serine-threonine kinase 2	-	HPRD	9575181
RYBP	AAP1 \| DEDAF \| YEAF1	RING1 and YY1 binding protein	-	HPRD	11395500
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	CASP8 (caspase-8) interacts with SUMO1.	BIND	15782135
TFCP2	CP2 \| LBP-1C \| LSF \| SEF \| TFCP2C	transcription factor CP2	Two-hybrid	BioGRID	16169070
TNFRSF10A	APO2 \| CD261 \| DR4 \| MGC9365 \| TRAILR-1 \| TRAILR1	tumor necrosis factor receptor superfamily, member 10a	Affinity Capture-Western	BioGRID	9325248
TNFRSF10A	APO2 \| CD261 \| DR4 \| MGC9365 \| TRAILR-1 \| TRAILR1	tumor necrosis factor receptor superfamily, member 10a	-	HPRD	12218097
TNFRSF10B	CD262 \| DR5 \| KILLER \| KILLER/DR5 \| TRAIL-R2 \| TRAILR2 \| TRICK2 \| TRICK2A \| TRICK2B \| TRICKB \| ZTNFR9	tumor necrosis factor receptor superfamily, member 10b	Affinity Capture-Western Co-purification	BioGRID	9325248 \|15659383
TNFRSF10B	CD262 \| DR5 \| KILLER \| KILLER/DR5 \| TRAIL-R2 \| TRAILR2 \| TRICK2 \| TRICK2A \| TRICK2B \| TRICKB \| ZTNFR9	tumor necrosis factor receptor superfamily, member 10b	-	HPRD	12218097
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	tumor necrosis factor receptor superfamily, member 1A	Co-purification	BioGRID	15659383
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	-	HPRD,BioGRID	12887920
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	Affinity Capture-Western Biochemical Activity	BioGRID	11098060 \|12887920
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	Affinity Capture-Western	BioGRID	12887920
VIM	FLJ36605	vimentin	Two-hybrid	BioGRID	16169070
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	Phenotypic Suppression	BioGRID	11832478

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG P53 SIGNALING PATHWAY	69	45	All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS	88	62	All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY	62	47	All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY	71	51	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
BIOCARTA CASPASE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA CERAMIDE PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA D4GDI PATHWAY	13	8	All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY	30	22	All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY	33	24	All SZGR 2.0 genes in this pathway
BIOCARTA MITOCHONDRIA PATHWAY	21	15	All SZGR 2.0 genes in this pathway
BIOCARTA SODD PATHWAY	10	7	All SZGR 2.0 genes in this pathway
BIOCARTA TNFR1 PATHWAY	29	21	All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY	29	20	All SZGR 2.0 genes in this pathway
SA CASPASE CASCADE	19	13	All SZGR 2.0 genes in this pathway
SA FAS SIGNALING	9	5	All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY	65	54	All SZGR 2.0 genes in this pathway
PID AR PATHWAY	61	46	All SZGR 2.0 genes in this pathway
PID TRAIL PATHWAY	28	20	All SZGR 2.0 genes in this pathway
PID FAS PATHWAY	38	29	All SZGR 2.0 genes in this pathway
PID TNF PATHWAY	46	33	All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY	48	37	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY	35	26	All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY	52	39	All SZGR 2.0 genes in this pathway
REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	13	8	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	40	26	All SZGR 2.0 genes in this pathway
REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	13	11	All SZGR 2.0 genes in this pathway
REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	12	9	All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	73	57	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY	30	22	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	46	33	All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	30	21	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE	54	37	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN	275	168	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE DN	61	35	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE DN	54	38	All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP	55	40	All SZGR 2.0 genes in this pathway
MARKS HDAC TARGETS UP	23	15	All SZGR 2.0 genes in this pathway
DUTTA APOPTOSIS VIA NFKB	33	25	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5	147	89	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
LA MEN1 TARGETS	24	15	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN	169	102	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP	197	110	All SZGR 2.0 genes in this pathway
DER IFN ALPHA RESPONSE UP	74	48	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP	205	126	All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP	102	67	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE UP	71	45	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70	67	33	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN	123	86	All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN	64	44	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D7	40	21	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6	153	112	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN	314	188	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN	373	196	All SZGR 2.0 genes in this pathway
GALI TP53 TARGETS APOPTOTIC UP	8	7	All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002	429	260	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
MIKKELSEN PLURIPOTENT STATE DN	8	7	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED	536	296	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 12	79	54	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL	216	130	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR	152	88	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway

Gene Page: CASP8