Gene Page: NR0B2

Summary ?
GeneID8431
SymbolNR0B2
SynonymsSHP|SHP1
Descriptionnuclear receptor subfamily 0 group B member 2
ReferenceMIM:604630|HGNC:HGNC:7961|Ensembl:ENSG00000131910|HPRD:05219|Vega:OTTHUMG00000004231
Gene typeprotein-coding
Map location1p36.1
Pascal p-value0.005
Fetal beta0.068
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
NR0B2chr127240176GANM_021969p.86R>WmissenseSchizophreniaDNM:Fromer_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ADAM110.880.88
HISPPD2A0.880.87
AC005277.10.870.89
RNF1570.870.89
TOM1L20.870.85
SYNGR10.870.87
PCNXL20.870.88
SNPH0.870.85
IQSEC30.870.87
STXBP10.870.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BCL7C-0.46-0.53
C9orf46-0.45-0.43
GNG11-0.44-0.46
MYL12A-0.43-0.52
RPL35-0.43-0.48
CLEC3B-0.43-0.54
RPS20-0.43-0.50
RPL31-0.42-0.43
RAB13-0.42-0.47
RAMP2-0.41-0.47

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID11735420 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID9773978 |11861507 
ESR2ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2estrogen receptor 2 (ER beta)-HPRD,BioGRID9773978 |10648597 
HNF4AFLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14hepatocyte nuclear factor 4, alphaReconstituted Complex
Two-hybrid		BioGRID10594021 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3Two-hybridBioGRID11668176 
NR1H2LXR-b | LXRB | NER | NER-I | RIP15 | UNRnuclear receptor subfamily 1, group H, member 2-HPRD,BioGRID12198243 
NR1H3LXR-a | LXRA | RLD-1nuclear receptor subfamily 1, group H, member 3Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12198243 
NR1I3CAR | CAR1 | MB67 | MGC150433 | MGC97144 | MGC97209nuclear receptor subfamily 1, group I, member 3-HPRD8650544|9773978 
NR5A2B1F | B1F2 | CPF | FTF | FTZ-F1 | FTZ-F1beta | LRH-1 | hB1F | hB1F-2nuclear receptor subfamily 5, group A, member 2-HPRD,BioGRID11668176 
NR5A2B1F | B1F2 | CPF | FTF | FTZ-F1 | FTZ-F1beta | LRH-1 | hB1F | hB1F-2nuclear receptor subfamily 5, group A, member 2hLRH-1 interacts with hSHP. This interaction was modelled on a demonstrated interaction between mouse LRH-1 and human SHP.BIND15707893 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaReconstituted ComplexBioGRID12198243 
PPARGNR1C3 | PPARG1 | PPARG2 | PPARgammaperoxisome proliferator-activated receptor gamma-HPRD,BioGRID11696534 
RARANR1B1 | RARretinoic acid receptor, alpha-HPRD,BioGRID9773978 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alpha-HPRD,BioGRID10594021 
RXRBDAUDI6 | H-2RIIBP | MGC1831 | NR2B2 | RCoR-1retinoid X receptor, beta-HPRD10594021 
RXRGNR2B3 | RXRCretinoid X receptor, gammaReconstituted ComplexBioGRID8650544 
THRAAR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)Reconstituted ComplexBioGRID8650544 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA PPARA PATHWAY 5843All SZGR 2.0 genes in this pathway
BIOCARTA NUCLEARRS PATHWAY 1512All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN B LYMPHOCYTES 3631All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY 4638All SZGR 2.0 genes in this pathway
ST INTERLEUKIN 4 PATHWAY 2618All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 6554All SZGR 2.0 genes in this pathway
PID ERB GENOMIC PATHWAY 158All SZGR 2.0 genes in this pathway
PID ERA GENOMIC PATHWAY 6537All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352181All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 4936All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS AND ESOPHAGUS CANCER UP 2612All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION HEMGN 3121All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN 200112All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249170All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K27ME3 7035All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 14280All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway