Gene Page: CCDC77
Summary ?
| GeneID | 84318 |
| Symbol | CCDC77 |
| Synonyms | - |
| Description | coiled-coil domain containing 77 |
| Reference | HGNC:HGNC:28203|Ensembl:ENSG00000120647|HPRD:17485|Vega:OTTHUMG00000129214 |
| Gene type | protein-coding |
| Map location | 12p13.33 |
| Pascal p-value | 0.789 |
| Sherlock p-value | 0.119 |
| Fetal beta | 1.614 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg07165616 | 12 | 498868 | CCDC77 | 6.9E-10 | -0.009 | 9.72E-7 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs486098 | 12 | 388657 | CCDC77 | ENSG00000120647.5 | 2.758E-7 | 0.01 | -110481 | gtex_brain_ba24 |
| rs189482670 | 12 | 402955 | CCDC77 | ENSG00000120647.5 | 2.129E-6 | 0.01 | -96183 | gtex_brain_ba24 |
| rs495316 | 12 | 383842 | CCDC77 | ENSG00000120647.5 | 2.629E-6 | 0.01 | -115296 | gtex_brain_putamen_basal |
| rs1207322 | 12 | 387132 | CCDC77 | ENSG00000120647.5 | 1.628E-6 | 0.01 | -112006 | gtex_brain_putamen_basal |
| rs507597 | 12 | 397404 | CCDC77 | ENSG00000120647.5 | 1.721E-7 | 0.01 | -101734 | gtex_brain_putamen_basal |
| rs17800744 | 12 | 400466 | CCDC77 | ENSG00000120647.5 | 1.717E-7 | 0.01 | -98672 | gtex_brain_putamen_basal |
| rs57022939 | 12 | 402647 | CCDC77 | ENSG00000120647.5 | 1.838E-6 | 0.01 | -96491 | gtex_brain_putamen_basal |
| rs201806016 | 12 | 404455 | CCDC77 | ENSG00000120647.5 | 8.432E-7 | 0.01 | -94683 | gtex_brain_putamen_basal |
| rs77854644 | 12 | 405043 | CCDC77 | ENSG00000120647.5 | 1.717E-7 | 0.01 | -94095 | gtex_brain_putamen_basal |
| rs4980875 | 12 | 407504 | CCDC77 | ENSG00000120647.5 | 1.838E-6 | 0.01 | -91634 | gtex_brain_putamen_basal |
| rs61906995 | 12 | 408770 | CCDC77 | ENSG00000120647.5 | 1.838E-6 | 0.01 | -90368 | gtex_brain_putamen_basal |
| rs4980813 | 12 | 414287 | CCDC77 | ENSG00000120647.5 | 1.628E-6 | 0.01 | -84851 | gtex_brain_putamen_basal |
| rs4980876 | 12 | 418777 | CCDC77 | ENSG00000120647.5 | 1.628E-6 | 0.01 | -80361 | gtex_brain_putamen_basal |
| rs12582850 | 12 | 421234 | CCDC77 | ENSG00000120647.5 | 1.835E-6 | 0.01 | -77904 | gtex_brain_putamen_basal |
| rs61906996 | 12 | 425473 | CCDC77 | ENSG00000120647.5 | 1.628E-6 | 0.01 | -73665 | gtex_brain_putamen_basal |
| rs4980878 | 12 | 427077 | CCDC77 | ENSG00000120647.5 | 1.835E-6 | 0.01 | -72061 | gtex_brain_putamen_basal |
| rs11608938 | 12 | 428693 | CCDC77 | ENSG00000120647.5 | 1.789E-7 | 0.01 | -70445 | gtex_brain_putamen_basal |
| rs3213751 | 12 | 432666 | CCDC77 | ENSG00000120647.5 | 1.892E-6 | 0.01 | -66472 | gtex_brain_putamen_basal |
| rs3815558 | 12 | 433151 | CCDC77 | ENSG00000120647.5 | 2.046E-6 | 0.01 | -65987 | gtex_brain_putamen_basal |
| rs61907026 | 12 | 433900 | CCDC77 | ENSG00000120647.5 | 2.07E-7 | 0.01 | -65238 | gtex_brain_putamen_basal |
| rs78998485 | 12 | 434755 | CCDC77 | ENSG00000120647.5 | 2.046E-6 | 0.01 | -64383 | gtex_brain_putamen_basal |
| rs79839498 | 12 | 440257 | CCDC77 | ENSG00000120647.5 | 1.378E-7 | 0.01 | -58881 | gtex_brain_putamen_basal |
| rs4980884 | 12 | 442354 | CCDC77 | ENSG00000120647.5 | 2.049E-6 | 0.01 | -56784 | gtex_brain_putamen_basal |
| rs4980814 | 12 | 443795 | CCDC77 | ENSG00000120647.5 | 1.628E-6 | 0.01 | -55343 | gtex_brain_putamen_basal |
| rs61907030 | 12 | 452232 | CCDC77 | ENSG00000120647.5 | 2.056E-7 | 0.01 | -46906 | gtex_brain_putamen_basal |
| rs61907031 | 12 | 452325 | CCDC77 | ENSG00000120647.5 | 2.056E-7 | 0.01 | -46813 | gtex_brain_putamen_basal |
| rs11615564 | 12 | 457843 | CCDC77 | ENSG00000120647.5 | 1.73E-7 | 0.01 | -41295 | gtex_brain_putamen_basal |
| rs7135768 | 12 | 460226 | CCDC77 | ENSG00000120647.5 | 2.046E-6 | 0.01 | -38912 | gtex_brain_putamen_basal |
| rs7965038 | 12 | 466176 | CCDC77 | ENSG00000120647.5 | 1.714E-7 | 0.01 | -32962 | gtex_brain_putamen_basal |
| rs2041299 | 12 | 468019 | CCDC77 | ENSG00000120647.5 | 1.704E-7 | 0.01 | -31119 | gtex_brain_putamen_basal |
| rs6489450 | 12 | 470428 | CCDC77 | ENSG00000120647.5 | 2.042E-6 | 0.01 | -28710 | gtex_brain_putamen_basal |
| rs6489452 | 12 | 471476 | CCDC77 | ENSG00000120647.5 | 1.991E-7 | 0.01 | -27662 | gtex_brain_putamen_basal |
| rs2098094 | 12 | 485095 | CCDC77 | ENSG00000120647.5 | 2.492E-6 | 0.01 | -14043 | gtex_brain_putamen_basal |
| rs2159364 | 12 | 485608 | CCDC77 | ENSG00000120647.5 | 1.819E-6 | 0.01 | -13530 | gtex_brain_putamen_basal |
| rs7977462 | 12 | 485791 | CCDC77 | ENSG00000120647.5 | 1.284E-6 | 0.01 | -13347 | gtex_brain_putamen_basal |
| rs397743980 | 12 | 488640 | CCDC77 | ENSG00000120647.5 | 1.714E-7 | 0.01 | -10498 | gtex_brain_putamen_basal |
| rs10744616 | 12 | 489205 | CCDC77 | ENSG00000120647.5 | 1.716E-6 | 0.01 | -9933 | gtex_brain_putamen_basal |
| rs10774150 | 12 | 493443 | CCDC77 | ENSG00000120647.5 | 1.626E-6 | 0.01 | -5695 | gtex_brain_putamen_basal |
| rs1860360 | 12 | 493900 | CCDC77 | ENSG00000120647.5 | 1.835E-6 | 0.01 | -5238 | gtex_brain_putamen_basal |
| rs1011699 | 12 | 494186 | CCDC77 | ENSG00000120647.5 | 2.24E-7 | 0.01 | -4952 | gtex_brain_putamen_basal |
| rs6489475 | 12 | 495558 | CCDC77 | ENSG00000120647.5 | 1.714E-7 | 0.01 | -3580 | gtex_brain_putamen_basal |
| rs10774154 | 12 | 496695 | CCDC77 | ENSG00000120647.5 | 2.43E-6 | 0.01 | -2443 | gtex_brain_putamen_basal |
| rs2253565 | 12 | 497910 | CCDC77 | ENSG00000120647.5 | 1.778E-6 | 0.01 | -1228 | gtex_brain_putamen_basal |
| rs1155942 | 12 | 501076 | CCDC77 | ENSG00000120647.5 | 3.7E-7 | 0.01 | 1938 | gtex_brain_putamen_basal |
| rs7133796 | 12 | 502025 | CCDC77 | ENSG00000120647.5 | 3.071E-7 | 0.01 | 2887 | gtex_brain_putamen_basal |
| rs201670349 | 12 | 502184 | CCDC77 | ENSG00000120647.5 | 8.306E-7 | 0.01 | 3046 | gtex_brain_putamen_basal |
| rs2369277 | 12 | 502472 | CCDC77 | ENSG00000120647.5 | 8.39E-7 | 0.01 | 3334 | gtex_brain_putamen_basal |
| rs9805067 | 12 | 505333 | CCDC77 | ENSG00000120647.5 | 9.973E-7 | 0.01 | 6195 | gtex_brain_putamen_basal |
| rs1541464 | 12 | 505839 | CCDC77 | ENSG00000120647.5 | 6.39E-7 | 0.01 | 6701 | gtex_brain_putamen_basal |
| rs1541465 | 12 | 505920 | CCDC77 | ENSG00000120647.5 | 7.155E-7 | 0.01 | 6782 | gtex_brain_putamen_basal |
| rs4980817 | 12 | 506893 | CCDC77 | ENSG00000120647.5 | 1.117E-6 | 0.01 | 7755 | gtex_brain_putamen_basal |
| rs7972566 | 12 | 517059 | CCDC77 | ENSG00000120647.5 | 4.241E-7 | 0.01 | 17921 | gtex_brain_putamen_basal |
| rs10774170 | 12 | 517521 | CCDC77 | ENSG00000120647.5 | 2.916E-7 | 0.01 | 18383 | gtex_brain_putamen_basal |
| rs11062803 | 12 | 518303 | CCDC77 | ENSG00000120647.5 | 5.87E-7 | 0.01 | 19165 | gtex_brain_putamen_basal |
| rs10744627 | 12 | 518795 | CCDC77 | ENSG00000120647.5 | 6.206E-7 | 0.01 | 19657 | gtex_brain_putamen_basal |
| rs11062813 | 12 | 518986 | CCDC77 | ENSG00000120647.5 | 5.188E-7 | 0.01 | 19848 | gtex_brain_putamen_basal |
| rs7136116 | 12 | 522975 | CCDC77 | ENSG00000120647.5 | 1.723E-6 | 0.01 | 23837 | gtex_brain_putamen_basal |
| rs11610457 | 12 | 523350 | CCDC77 | ENSG00000120647.5 | 1.403E-6 | 0.01 | 24212 | gtex_brain_putamen_basal |
| rs11613357 | 12 | 557394 | CCDC77 | ENSG00000120647.5 | 4.42E-7 | 0.01 | 58256 | gtex_brain_putamen_basal |
| rs2191159 | 12 | 558019 | CCDC77 | ENSG00000120647.5 | 1.888E-6 | 0.01 | 58881 | gtex_brain_putamen_basal |
| rs12372234 | 12 | 558423 | CCDC77 | ENSG00000120647.5 | 2.459E-6 | 0.01 | 59285 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN | 180 | 101 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC ICP WITH H3K4ME3 | 445 | 257 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION UP | 570 | 339 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS UP | 279 | 155 | All SZGR 2.0 genes in this pathway |