Gene Page: DYDC2
Summary ?
| GeneID | 84332 |
| Symbol | DYDC2 |
| Synonyms | - |
| Description | DPY30 domain containing 2 |
| Reference | HGNC:HGNC:23468|Ensembl:ENSG00000133665|HPRD:11311|Vega:OTTHUMG00000018610 |
| Gene type | protein-coding |
| Map location | 10q23.1 |
| Pascal p-value | 0.042 |
| Fetal beta | 0.184 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg11700985 | 10 | 82127205 | DYDC2 | 2.225E-4 | 0.29 | 0.036 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10788562 | chr10 | 82072309 | DYDC2 | 84332 | 0.11 | cis | ||
| rs10466235 | chr10 | 82149654 | DYDC2 | 84332 | 0 | cis | ||
| rs4934134 | chr10 | 82160581 | DYDC2 | 84332 | 0.1 | cis | ||
| rs10887933 | chr10 | 82223766 | DYDC2 | 84332 | 0.2 | cis | ||
| rs1766249 | chr10 | 120343776 | DYDC2 | 84332 | 0.08 | trans | ||
| rs71482774 | 10 | 82074883 | DYDC2 | ENSG00000133665.8 | 9.91E-7 | 0 | -29618 | gtex_brain_putamen_basal |
| rs7099331 | 10 | 82086406 | DYDC2 | ENSG00000133665.8 | 2.937E-6 | 0 | -18095 | gtex_brain_putamen_basal |
| rs10887761 | 10 | 82088572 | DYDC2 | ENSG00000133665.8 | 1.649E-6 | 0 | -15929 | gtex_brain_putamen_basal |
| rs55901776 | 10 | 82089493 | DYDC2 | ENSG00000133665.8 | 1.154E-6 | 0 | -15008 | gtex_brain_putamen_basal |
| rs1340381 | 10 | 82100754 | DYDC2 | ENSG00000133665.8 | 1.612E-6 | 0 | -3747 | gtex_brain_putamen_basal |
| rs10749561 | 10 | 82107061 | DYDC2 | ENSG00000133665.8 | 1.466E-6 | 0 | 2560 | gtex_brain_putamen_basal |
| rs1934697 | 10 | 82112873 | DYDC2 | ENSG00000133665.8 | 1.652E-6 | 0 | 8372 | gtex_brain_putamen_basal |
| rs4146515 | 10 | 82116602 | DYDC2 | ENSG00000133665.8 | 1.492E-10 | 0 | 12101 | gtex_brain_putamen_basal |
| rs10788586 | 10 | 82117435 | DYDC2 | ENSG00000133665.8 | 3.148E-6 | 0 | 12934 | gtex_brain_putamen_basal |
| rs6585946 | 10 | 82118292 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 13791 | gtex_brain_putamen_basal |
| rs7909792 | 10 | 82118870 | DYDC2 | ENSG00000133665.8 | 1.219E-6 | 0 | 14369 | gtex_brain_putamen_basal |
| rs4536152 | 10 | 82119242 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 14741 | gtex_brain_putamen_basal |
| rs4468295 | 10 | 82119276 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 14775 | gtex_brain_putamen_basal |
| rs4601708 | 10 | 82119583 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 15082 | gtex_brain_putamen_basal |
| rs1538822 | 10 | 82120104 | DYDC2 | ENSG00000133665.8 | 8.743E-7 | 0 | 15603 | gtex_brain_putamen_basal |
| rs1340379 | 10 | 82121455 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 16954 | gtex_brain_putamen_basal |
| rs1538819 | 10 | 82122523 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 18022 | gtex_brain_putamen_basal |
| rs113803551 | 10 | 82123268 | DYDC2 | ENSG00000133665.8 | 1.991E-6 | 0 | 18767 | gtex_brain_putamen_basal |
| rs2050824 | 10 | 82123563 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 19062 | gtex_brain_putamen_basal |
| rs7098045 | 10 | 82123856 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 19355 | gtex_brain_putamen_basal |
| rs7077854 | 10 | 82124070 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 19569 | gtex_brain_putamen_basal |
| rs7089003 | 10 | 82124155 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 19654 | gtex_brain_putamen_basal |
| rs1934696 | 10 | 82124966 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 20465 | gtex_brain_putamen_basal |
| rs1934694 | 10 | 82125325 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 20824 | gtex_brain_putamen_basal |
| rs1934693 | 10 | 82125650 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 21149 | gtex_brain_putamen_basal |
| rs1934692 | 10 | 82125734 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 21233 | gtex_brain_putamen_basal |
| rs1047952 | 10 | 82126808 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 22307 | gtex_brain_putamen_basal |
| rs1972371 | 10 | 82127111 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 22610 | gtex_brain_putamen_basal |
| rs946892 | 10 | 82127551 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 23050 | gtex_brain_putamen_basal |
| rs2095994 | 10 | 82127956 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 23455 | gtex_brain_putamen_basal |
| rs397731386 | 10 | 82128395 | DYDC2 | ENSG00000133665.8 | 3.478E-6 | 0 | 23894 | gtex_brain_putamen_basal |
| rs1340376 | 10 | 82128963 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 24462 | gtex_brain_putamen_basal |
| rs1340375 | 10 | 82129039 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 24538 | gtex_brain_putamen_basal |
| rs1340374 | 10 | 82129114 | DYDC2 | ENSG00000133665.8 | 3.142E-6 | 0 | 24613 | gtex_brain_putamen_basal |
| rs1340373 | 10 | 82129250 | DYDC2 | ENSG00000133665.8 | 2.938E-6 | 0 | 24749 | gtex_brain_putamen_basal |
| rs7903701 | 10 | 82129268 | DYDC2 | ENSG00000133665.8 | 3.139E-6 | 0 | 24767 | gtex_brain_putamen_basal |
| rs10749569 | 10 | 82129892 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 25391 | gtex_brain_putamen_basal |
| rs4357632 | 10 | 82131783 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 27282 | gtex_brain_putamen_basal |
| rs10736343 | 10 | 82132152 | DYDC2 | ENSG00000133665.8 | 8.743E-7 | 0 | 27651 | gtex_brain_putamen_basal |
| rs72515585 | 10 | 82132585 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 28084 | gtex_brain_putamen_basal |
| rs7897994 | 10 | 82133304 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 28803 | gtex_brain_putamen_basal |
| rs7919380 | 10 | 82133380 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 28879 | gtex_brain_putamen_basal |
| rs10736344 | 10 | 82133955 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 29454 | gtex_brain_putamen_basal |
| rs10736345 | 10 | 82134140 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 29639 | gtex_brain_putamen_basal |
| rs10736346 | 10 | 82134281 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 29780 | gtex_brain_putamen_basal |
| rs10736347 | 10 | 82134465 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 29964 | gtex_brain_putamen_basal |
| rs9804233 | 10 | 82134667 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 30166 | gtex_brain_putamen_basal |
| rs7077712 | 10 | 82134894 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 30393 | gtex_brain_putamen_basal |
| rs7077847 | 10 | 82134952 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 30451 | gtex_brain_putamen_basal |
| rs7082093 | 10 | 82134954 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 30453 | gtex_brain_putamen_basal |
| rs35353819 | 10 | 82135737 | DYDC2 | ENSG00000133665.8 | 3.161E-6 | 0 | 31236 | gtex_brain_putamen_basal |
| rs11202721 | 10 | 82135762 | DYDC2 | ENSG00000133665.8 | 1.803E-6 | 0 | 31261 | gtex_brain_putamen_basal |
| rs11202724 | 10 | 82136190 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 31689 | gtex_brain_putamen_basal |
| rs11202725 | 10 | 82136276 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 31775 | gtex_brain_putamen_basal |
| rs10749572 | 10 | 82136664 | DYDC2 | ENSG00000133665.8 | 5.693E-10 | 0 | 32163 | gtex_brain_putamen_basal |
| rs10749573 | 10 | 82136839 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 32338 | gtex_brain_putamen_basal |
| rs10749575 | 10 | 82136921 | DYDC2 | ENSG00000133665.8 | 5.683E-10 | 0 | 32420 | gtex_brain_putamen_basal |
| rs10887808 | 10 | 82137367 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 32866 | gtex_brain_putamen_basal |
| rs1538815 | 10 | 82137670 | DYDC2 | ENSG00000133665.8 | 3.132E-6 | 0 | 33169 | gtex_brain_putamen_basal |
| rs398075349 | 10 | 82138736 | DYDC2 | ENSG00000133665.8 | 3.267E-6 | 0 | 34235 | gtex_brain_putamen_basal |
| rs10736348 | 10 | 82139244 | DYDC2 | ENSG00000133665.8 | 3.032E-6 | 0 | 34743 | gtex_brain_putamen_basal |
| rs6585967 | 10 | 82139791 | DYDC2 | ENSG00000133665.8 | 3.188E-6 | 0 | 35290 | gtex_brain_putamen_basal |
| rs7905891 | 10 | 82139813 | DYDC2 | ENSG00000133665.8 | 2.333E-6 | 0 | 35312 | gtex_brain_putamen_basal |
| rs7906131 | 10 | 82139955 | DYDC2 | ENSG00000133665.8 | 1.033E-6 | 0 | 35454 | gtex_brain_putamen_basal |
| rs10749579 | 10 | 82140959 | DYDC2 | ENSG00000133665.8 | 3.211E-6 | 0 | 36458 | gtex_brain_putamen_basal |
| rs10749581 | 10 | 82141651 | DYDC2 | ENSG00000133665.8 | 3.223E-6 | 0 | 37150 | gtex_brain_putamen_basal |
| rs7090351 | 10 | 82142047 | DYDC2 | ENSG00000133665.8 | 3.266E-6 | 0 | 37546 | gtex_brain_putamen_basal |
| rs1953970 | 10 | 82142176 | DYDC2 | ENSG00000133665.8 | 1.676E-6 | 0 | 37675 | gtex_brain_putamen_basal |
| rs5786447 | 10 | 82143025 | DYDC2 | ENSG00000133665.8 | 2.526E-6 | 0 | 38524 | gtex_brain_putamen_basal |
| rs1815653 | 10 | 82143259 | DYDC2 | ENSG00000133665.8 | 1.949E-6 | 0 | 38758 | gtex_brain_putamen_basal |
| rs10788603 | 10 | 82148137 | DYDC2 | ENSG00000133665.8 | 2.023E-9 | 0 | 43636 | gtex_brain_putamen_basal |
| rs10466236 | 10 | 82149717 | DYDC2 | ENSG00000133665.8 | 6.359E-9 | 0 | 45216 | gtex_brain_putamen_basal |
| rs7914621 | 10 | 82150306 | DYDC2 | ENSG00000133665.8 | 7.671E-9 | 0 | 45805 | gtex_brain_putamen_basal |
| rs7896073 | 10 | 82150351 | DYDC2 | ENSG00000133665.8 | 2.26E-7 | 0 | 45850 | gtex_brain_putamen_basal |
| rs7899513 | 10 | 82150559 | DYDC2 | ENSG00000133665.8 | 7.467E-9 | 0 | 46058 | gtex_brain_putamen_basal |
| rs7899545 | 10 | 82150635 | DYDC2 | ENSG00000133665.8 | 7.534E-9 | 0 | 46134 | gtex_brain_putamen_basal |
| rs10749592 | 10 | 82150891 | DYDC2 | ENSG00000133665.8 | 8.539E-9 | 0 | 46390 | gtex_brain_putamen_basal |
| rs397702335 | 10 | 82151225 | DYDC2 | ENSG00000133665.8 | 4.792E-8 | 0 | 46724 | gtex_brain_putamen_basal |
| rs10887826 | 10 | 82151380 | DYDC2 | ENSG00000133665.8 | 4.843E-8 | 0 | 46879 | gtex_brain_putamen_basal |
| rs10887828 | 10 | 82151470 | DYDC2 | ENSG00000133665.8 | 4.864E-8 | 0 | 46969 | gtex_brain_putamen_basal |
| rs4934126 | 10 | 82151598 | DYDC2 | ENSG00000133665.8 | 4.892E-8 | 0 | 47097 | gtex_brain_putamen_basal |
| rs7916349 | 10 | 82152638 | DYDC2 | ENSG00000133665.8 | 5.085E-8 | 0 | 48137 | gtex_brain_putamen_basal |
| rs7907575 | 10 | 82152675 | DYDC2 | ENSG00000133665.8 | 5.092E-8 | 0 | 48174 | gtex_brain_putamen_basal |
| rs7907969 | 10 | 82153005 | DYDC2 | ENSG00000133665.8 | 3.85E-7 | 0 | 48504 | gtex_brain_putamen_basal |
| rs7898124 | 10 | 82153167 | DYDC2 | ENSG00000133665.8 | 9.705E-7 | 0 | 48666 | gtex_brain_putamen_basal |
| rs7912008 | 10 | 82153717 | DYDC2 | ENSG00000133665.8 | 2.879E-8 | 0 | 49216 | gtex_brain_putamen_basal |
| rs7902071 | 10 | 82153816 | DYDC2 | ENSG00000133665.8 | 1.006E-7 | 0 | 49315 | gtex_brain_putamen_basal |
| rs7898787 | 10 | 82156042 | DYDC2 | ENSG00000133665.8 | 5.623E-8 | 0 | 51541 | gtex_brain_putamen_basal |
| rs2050823 | 10 | 82156471 | DYDC2 | ENSG00000133665.8 | 7.322E-7 | 0 | 51970 | gtex_brain_putamen_basal |
| rs2050822 | 10 | 82156475 | DYDC2 | ENSG00000133665.8 | 7.174E-8 | 0 | 51974 | gtex_brain_putamen_basal |
| rs946890 | 10 | 82157402 | DYDC2 | ENSG00000133665.8 | 9.999E-8 | 0 | 52901 | gtex_brain_putamen_basal |
| rs59890890 | 10 | 82157721 | DYDC2 | ENSG00000133665.8 | 9.22E-8 | 0 | 53220 | gtex_brain_putamen_basal |
| rs12260866 | 10 | 82158261 | DYDC2 | ENSG00000133665.8 | 1.181E-7 | 0 | 53760 | gtex_brain_putamen_basal |
| rs12262748 | 10 | 82158300 | DYDC2 | ENSG00000133665.8 | 7.951E-8 | 0 | 53799 | gtex_brain_putamen_basal |
| rs7067612 | 10 | 82159037 | DYDC2 | ENSG00000133665.8 | 1.461E-8 | 0 | 54536 | gtex_brain_putamen_basal |
| rs7088400 | 10 | 82159093 | DYDC2 | ENSG00000133665.8 | 1.747E-8 | 0 | 54592 | gtex_brain_putamen_basal |
| rs7071752 | 10 | 82159539 | DYDC2 | ENSG00000133665.8 | 6.3E-8 | 0 | 55038 | gtex_brain_putamen_basal |
| rs12262228 | 10 | 82160425 | DYDC2 | ENSG00000133665.8 | 6.488E-8 | 0 | 55924 | gtex_brain_putamen_basal |
| rs4934134 | 10 | 82160582 | DYDC2 | ENSG00000133665.8 | 4.344E-8 | 0 | 56081 | gtex_brain_putamen_basal |
| rs7088374 | 10 | 82161088 | DYDC2 | ENSG00000133665.8 | 7.053E-8 | 0 | 56587 | gtex_brain_putamen_basal |
| rs6585994 | 10 | 82191643 | DYDC2 | ENSG00000133665.8 | 1.21E-6 | 0 | 87142 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| HATADA METHYLATED IN LUNG CANCER UP | 390 | 236 | All SZGR 2.0 genes in this pathway |