Summary ?
GeneID84417
SymbolC2orf40
SynonymsECRG4
Descriptionchromosome 2 open reading frame 40
ReferenceMIM:611752|HGNC:HGNC:24642|Ensembl:ENSG00000119147|HPRD:13261|Vega:OTTHUMG00000130921
Gene typeprotein-coding
Map location2q12.2
Pascal p-value0.295
Sherlock p-value8.406E-5
Fetal beta0.246
eGeneCaudate basal ganglia
Cerebellum
Cortex
Frontal Cortex BA9
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.0004 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00755 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17131472chr191962966C2orf40844170.18trans
rs17535450chr239900012C2orf40844170.09trans
rs2922180chr3125280472C2orf40844172.552E-4trans
rs2976809chr3125451738C2orf40844170trans
rs17005214chr482845432C2orf40844170.07trans
rs16894149chr561013724C2orf40844170.09trans
rs17056435chr5158453782C2orf40844170.12trans
rs283058chr6118625224C2orf40844170.18trans
rs2739708chr817992280C2orf40844170.19trans
rs2739726chr817998576C2orf40844170.13trans
rs2919377chr832573740C2orf40844170.15trans
rs16908622chr8139231604C2orf40844170.07trans
rs9423711chr102574802C2orf40844170.17trans
rs17134872chr1176139845C2orf40844170.09trans
rs11236774chr1176234952C2orf40844170.09trans
rs11112163chr12105072508C2orf40844170.19trans
rs7358856chr1341931609C2orf40844170.16trans
rs7358853chr1341931685C2orf40844170.19trans
rs4349050chr1341958722C2orf40844170.09trans
rs7982172chr1341969697C2orf40844170.17trans
rs4942043chr1341978218C2orf40844170.08trans
rs17073665chr1381541961C2orf40844170.16trans
rs8043029chr1555486010C2orf40844170.07trans
rs3809540chr1555489411C2orf40844170.08trans
rs7165491chr1555500454C2orf40844170.18trans
rs7164640chr1580661303C2orf40844170.18trans
rs11660674chr1810202806C2orf40844170.15trans
rs11873703chr1861448702C2orf40844172.116E-4trans
rs6095741chr2048666589C2orf40844170trans
rs17789442chr2121289474C2orf40844170.02trans
rs5991662chrX43335796C2orf40844178.082E-4trans
rs130145212106687456C2orf40ENSG00000119147.51.268E-607754gtex_brain_putamen_basal
rs669896382106689736C2orf40ENSG00000119147.56.1E-7010034gtex_brain_putamen_basal
rs709535572106700964C2orf40ENSG00000119147.55.337E-7021262gtex_brain_putamen_basal
rs126218362106705747C2orf40ENSG00000119147.55.398E-7026045gtex_brain_putamen_basal
rs3684929792106705929C2orf40ENSG00000119147.55.409E-7026227gtex_brain_putamen_basal
rs130013982106706640C2orf40ENSG00000119147.55.45E-7026938gtex_brain_putamen_basal
rs130240762106706647C2orf40ENSG00000119147.58.459E-8026945gtex_brain_putamen_basal
rs38208932106707977C2orf40ENSG00000119147.56.401E-7028275gtex_brain_putamen_basal
rs347959492106711400C2orf40ENSG00000119147.52.44E-7031698gtex_brain_putamen_basal
rs130173822106720110C2orf40ENSG00000119147.52.44E-7040408gtex_brain_putamen_basal
rs38208922106728795C2orf40ENSG00000119147.58.504E-7049093gtex_brain_putamen_basal
rs129963452106730576C2orf40ENSG00000119147.52.44E-7050874gtex_brain_putamen_basal
rs130188162106740632C2orf40ENSG00000119147.55.152E-7060930gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIDA18029348 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
LIU PROSTATE CANCER DN 481290All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349157All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198110All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL DN 6943All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291176All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170114All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS DN 6441All SZGR 2.0 genes in this pathway
LEIN CHOROID PLEXUS MARKERS 10361All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250168All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221150All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS UP 10878All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306191All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 14280All SZGR 2.0 genes in this pathway
MIKKELSEN NPC LCP WITH H3K4ME3 5834All SZGR 2.0 genes in this pathway
STAMBOLSKY BOUND BY MUTATED TP53 1812All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway