Summary ?
GeneID84466
SymbolMEGF10
SynonymsEMARDD
Descriptionmultiple EGF like domains 10
ReferenceMIM:612453|HGNC:HGNC:29634|Ensembl:ENSG00000145794|HPRD:14384|Vega:OTTHUMG00000128984
Gene typeprotein-coding
Map location5q33
Pascal p-value0.018
Sherlock p-value0.509
Fetal beta-0.177
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_IGenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0086 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg264656115126626719MEGF102.147E-4-0.4640.036DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs9875049chr356457469MEGF10844660.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionIEA-
GO:0006909phagocytosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0016323basolateral plasma membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AARS2AARSL | KIAA1270 | MT-ALARS | MTALARS | bA444E17.1alanyl-tRNA synthetase 2, mitochondrial (putative)-HPRD12421765 
ALMS1ALSS | DKFZp686A118 | DKFZp686D1828 | KIAA0328Alstrom syndrome 1-HPRD12421765 
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunit-HPRD12421765 
BAHD1KIAA0945bromo adjacent homology domain containing 1-HPRD12421765 
CADPS2FLJ40851 | KIAA1591Ca++-dependent secretion activator 2-HPRD12421765 
CEP57KIAA0092 | PIG8 | TSP57centrosomal protein 57kDa-HPRD12421765 
CUL7KIAA0076 | dJ20C7.5cullin 7-HPRD12421765 
DHX16DBP2 | DDX16 | PRO2014 | PRP8DEAH (Asp-Glu-Ala-His) box polypeptide 16-HPRD12421765 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10-HPRD12421765 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4-HPRD12421765 
ITSN2KIAA1256 | PRO2015 | SH3D1B | SH3P18 | SWA | SWAPintersectin 2-HPRD12421765 
KIAA0564FLJ21779KIAA0564-HPRD12421765 
KIAA1598DKFZp686A0439 | MGC40476 | shootin-1KIAA1598-HPRD12421765 
MCF2L2DKFZp686K0690 | FLJ42509 | KIAA0861MCF.2 cell line derived transforming sequence-like 2-HPRD12421765 
RANBP10FLJ31165 | KIAA1464RAN binding protein 10-HPRD12421765 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD12421765 
SART3DSAP1 | KIAA0156 | MGC138188 | P100 | RP11-13G14 | TIP110 | p110 | p110(nrb)squamous cell carcinoma antigen recognized by T cells 3-HPRD12421765 
SCAPERFLJ31533 | FLJ31953 | KIAA1454 | MSTP063 | ZNF291 | Zfp291S phase cyclin A-associated protein in the ER-HPRD12421765 
SNRNP200ASCC3L1 | BRR2 | HELIC2 | U5-200KDsmall nuclear ribonucleoprotein 200kDa (U5)-HPRD12421765 
TAOK2KIAA0881 | MAP3K17 | PSK | PSK1 | TAO1 | TAO2TAO kinase 2-HPRD12421765 
TMEM132ADKFZp547E212 | FLJ20539 | GBP | HSPA5BP1 | MGC138669transmembrane protein 132A-HPRD12421765 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238144All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP 11466All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G DN 3518All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS DN 6441All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266171All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469239All SZGR 2.0 genes in this pathway
MCCABE HOXC6 TARGETS DN 2115All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 12683All SZGR 2.0 genes in this pathway
PYEON CANCER HEAD AND NECK VS CERVICAL DN 2911All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199143All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway