Summary ?
GeneID8453
SymbolCUL2
Synonyms-
Descriptioncullin 2
ReferenceMIM:603135|HGNC:HGNC:2552|Ensembl:ENSG00000108094|HPRD:06786|Vega:OTTHUMG00000017950
Gene typeprotein-coding
Map location10p11.21
Pascal p-value0.092
Sherlock p-value0.382
Fetal beta-0.347
DMG1 (# studies)
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0312 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg184264871035379348CUL23.772E-4-0.3070.043DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
IFI350.940.90
OASL0.940.82
OAS10.930.78
IFI60.920.80
ISG150.900.78
BST20.900.87
PSMB80.890.88
IFITM30.860.93
TAP10.840.77
MT1E0.840.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DDX42-0.59-0.76
ABCF1-0.58-0.75
ARFGAP1-0.58-0.66
GGNBP2-0.58-0.76
USP7-0.58-0.76
SFRS14-0.58-0.81
CCDC49-0.58-0.83
C14orf102-0.57-0.74
SF3B2-0.57-0.81
PELP1-0.57-0.78

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12609982 |17353931 
GO:0031625ubiquitin protein ligase bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000082G1/S transition of mitotic cell cycleTAS8681378 
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0007050cell cycle arrestTAS8681378 
GO:0008285negative regulation of cell proliferationTAS8681378 
GO:0008629induction of apoptosis by intracellular signalsTAS8681378 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0031461cullin-RING ubiquitin ligase complexIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAB39CGI-66 | FLJ22682 | MO25calcium binding protein 39Affinity Capture-MSBioGRID17353931 
CAND1DKFZp434M1414 | FLJ10114 | FLJ10929 | FLJ38691 | FLJ90441 | KIAA0829 | TIP120 | TIP120Acullin-associated and neddylation-dissociated 1Affinity Capture-MS
Affinity Capture-Western
BioGRID12609982 
CMBLFLJ23617carboxymethylenebutenolidase homolog (Pseudomonas)Affinity Capture-MSBioGRID17353931 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)Affinity Capture-MSBioGRID17353931 
GPS1COPS1 | CSN1 | MGC71287G protein pathway suppressor 1-HPRD11337588 
KCTD5FLJ20040potassium channel tetramerisation domain containing 5Affinity Capture-MSBioGRID17353931 
P4HBDSI | ERBA2L | GIT | PDI | PDIA1 | PHDB | PO4DB | PO4HB | PROHBprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideAffinity Capture-MSBioGRID17353931 
PFKFB3IPFK2 | PFK26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3Affinity Capture-MSBioGRID17353931 
RBX1BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1ring-box 1Affinity Capture-MSBioGRID12481031 
RNF7CKBBP1 | ROC2 | SAGring finger protein 7-HPRD,BioGRID10230407 
RNMTL1FLJ10581 | HC90RNA methyltransferase like 1Affinity Capture-MSBioGRID17353931 
STOMBND7 | EPB7 | EPB72stomatinAffinity Capture-MSBioGRID17353931 
TCEB1SIIItranscription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)Reconstituted ComplexBioGRID11384984 
TCEB2ELOB | SIIItranscription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)Reconstituted ComplexBioGRID11384984 
TFE3RCCP2 | TFEA | bHLHe33transcription factor binding to IGHM enhancer 3Affinity Capture-MSBioGRID17353931 
TIMM13TIM13 | TIM13B | TIMM13A | TIMM13B | ppv1translocase of inner mitochondrial membrane 13 homolog (yeast)Affinity Capture-MSBioGRID17353931 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
BioGRID10587522 |11384984 
|17353931 
hCG_1983332LOC441246hCG1983332Affinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 13898All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 7060All SZGR 2.0 genes in this pathway
PID HIF1A PATHWAY 1912All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN 2517All SZGR 2.0 genes in this pathway
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA 1812All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206111All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320184All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 XPCS DN 8871All SZGR 2.0 genes in this pathway
MIDORIKAWA AMPLIFIED IN LIVER CANCER 5538All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 6 8454All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER LARGE VS TINY DN 4524All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
KAMMINGA EZH2 TARGETS 4126All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215132All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165106All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163113All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP 8363All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225124All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-142-5p210216m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-15/16/195/424/497417423m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-30-5p1211281A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA