Gene Page: CUL2
Summary ?
| GeneID | 8453 |
| Symbol | CUL2 |
| Synonyms | - |
| Description | cullin 2 |
| Reference | MIM:603135|HGNC:HGNC:2552|Ensembl:ENSG00000108094|HPRD:06786|Vega:OTTHUMG00000017950 |
| Gene type | protein-coding |
| Map location | 10p11.21 |
| Pascal p-value | 0.092 |
| Sherlock p-value | 0.382 |
| Fetal beta | -0.347 |
| DMG | 1 (# studies) |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0312 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg18426487 | 10 | 35379348 | CUL2 | 3.772E-4 | -0.307 | 0.043 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| IFI35 | 0.94 | 0.90 |
| OASL | 0.94 | 0.82 |
| OAS1 | 0.93 | 0.78 |
| IFI6 | 0.92 | 0.80 |
| ISG15 | 0.90 | 0.78 |
| BST2 | 0.90 | 0.87 |
| PSMB8 | 0.89 | 0.88 |
| IFITM3 | 0.86 | 0.93 |
| TAP1 | 0.84 | 0.77 |
| MT1E | 0.84 | 0.88 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DDX42 | -0.59 | -0.76 |
| ABCF1 | -0.58 | -0.75 |
| ARFGAP1 | -0.58 | -0.66 |
| GGNBP2 | -0.58 | -0.76 |
| USP7 | -0.58 | -0.76 |
| SFRS14 | -0.58 | -0.81 |
| CCDC49 | -0.58 | -0.83 |
| C14orf102 | -0.57 | -0.74 |
| SF3B2 | -0.57 | -0.81 |
| PELP1 | -0.57 | -0.78 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12609982 |17353931 | |
| GO:0031625 | ubiquitin protein ligase binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | 8681378 | |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | - | |
| GO:0007050 | cell cycle arrest | TAS | 8681378 | |
| GO:0008285 | negative regulation of cell proliferation | TAS | 8681378 | |
| GO:0008629 | induction of apoptosis by intracellular signals | TAS | 8681378 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0031461 | cullin-RING ubiquitin ligase complex | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CAB39 | CGI-66 | FLJ22682 | MO25 | calcium binding protein 39 | Affinity Capture-MS | BioGRID | 17353931 |
| CAND1 | DKFZp434M1414 | FLJ10114 | FLJ10929 | FLJ38691 | FLJ90441 | KIAA0829 | TIP120 | TIP120A | cullin-associated and neddylation-dissociated 1 | Affinity Capture-MS Affinity Capture-Western | BioGRID | 12609982 |
| CMBL | FLJ23617 | carboxymethylenebutenolidase homolog (Pseudomonas) | Affinity Capture-MS | BioGRID | 17353931 |
| DLG3 | KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102 | discs, large homolog 3 (neuroendocrine-dlg, Drosophila) | Affinity Capture-MS | BioGRID | 17353931 |
| GPS1 | COPS1 | CSN1 | MGC71287 | G protein pathway suppressor 1 | - | HPRD | 11337588 |
| KCTD5 | FLJ20040 | potassium channel tetramerisation domain containing 5 | Affinity Capture-MS | BioGRID | 17353931 |
| P4HB | DSI | ERBA2L | GIT | PDI | PDIA1 | PHDB | PO4DB | PO4HB | PROHB | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | Affinity Capture-MS | BioGRID | 17353931 |
| PFKFB3 | IPFK2 | PFK2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Affinity Capture-MS | BioGRID | 17353931 |
| RBX1 | BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1 | ring-box 1 | Affinity Capture-MS | BioGRID | 12481031 |
| RNF7 | CKBBP1 | ROC2 | SAG | ring finger protein 7 | - | HPRD,BioGRID | 10230407 |
| RNMTL1 | FLJ10581 | HC90 | RNA methyltransferase like 1 | Affinity Capture-MS | BioGRID | 17353931 |
| STOM | BND7 | EPB7 | EPB72 | stomatin | Affinity Capture-MS | BioGRID | 17353931 |
| TCEB1 | SIII | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) | Reconstituted Complex | BioGRID | 11384984 |
| TCEB2 | ELOB | SIII | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) | Reconstituted Complex | BioGRID | 11384984 |
| TFE3 | RCCP2 | TFEA | bHLHe33 | transcription factor binding to IGHM enhancer 3 | Affinity Capture-MS | BioGRID | 17353931 |
| TIMM13 | TIM13 | TIM13B | TIMM13A | TIMM13B | ppv1 | translocase of inner mitochondrial membrane 13 homolog (yeast) | Affinity Capture-MS | BioGRID | 17353931 |
| VHL | HRCA1 | RCA1 | VHL1 | von Hippel-Lindau tumor suppressor | Affinity Capture-MS Affinity Capture-Western Reconstituted Complex | BioGRID | 10587522 |11384984 |17353931 |
| hCG_1983332 | LOC441246 | hCG1983332 | Affinity Capture-MS | BioGRID | 17353931 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG UBIQUITIN MEDIATED PROTEOLYSIS | 138 | 98 | All SZGR 2.0 genes in this pathway |
| KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG RENAL CELL CARCINOMA | 70 | 60 | All SZGR 2.0 genes in this pathway |
| PID HIF1A PATHWAY | 19 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | 25 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | 18 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 251 | 156 | All SZGR 2.0 genes in this pathway |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 212 | 129 | All SZGR 2.0 genes in this pathway |
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP | 206 | 111 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS DN | 431 | 263 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN | 320 | 184 | All SZGR 2.0 genes in this pathway |
| TIEN INTESTINE PROBIOTICS 24HR UP | 557 | 331 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 XPCS DN | 88 | 71 | All SZGR 2.0 genes in this pathway |
| MIDORIKAWA AMPLIFIED IN LIVER CANCER | 55 | 38 | All SZGR 2.0 genes in this pathway |
| RASHI RESPONSE TO IONIZING RADIATION 6 | 84 | 54 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
| LIANG HEMATOPOIESIS STEM CELL NUMBER LARGE VS TINY DN | 45 | 24 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| LOCKWOOD AMPLIFIED IN LUNG CANCER | 214 | 139 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS UP | 424 | 268 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| KAMMINGA EZH2 TARGETS | 41 | 26 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| YAMAZAKI TCEB3 TARGETS DN | 215 | 132 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT DN | 165 | 106 | All SZGR 2.0 genes in this pathway |
| HEDENFALK BREAST CANCER BRCA1 VS BRCA2 | 163 | 113 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP | 83 | 63 | All SZGR 2.0 genes in this pathway |
| KYNG WERNER SYNDROM AND NORMAL AGING DN | 225 | 124 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
| miRNA family | Target position | miRNA ID | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-142-5p | 210 | 216 | m8 | hsa-miR-142-5p | CAUAAAGUAGAAAGCACUAC |
| miR-15/16/195/424/497 | 417 | 423 | m8 | hsa-miR-15abrain | UAGCAGCACAUAAUGGUUUGUG |
| hsa-miR-16brain | UAGCAGCACGUAAAUAUUGGCG | ||||
| hsa-miR-15bbrain | UAGCAGCACAUCAUGGUUUACA | ||||
| hsa-miR-195SZ | UAGCAGCACAGAAAUAUUGGC | ||||
| hsa-miR-424 | CAGCAGCAAUUCAUGUUUUGAA | ||||
| hsa-miR-497 | CAGCAGCACACUGUGGUUUGU | ||||
| miR-30-5p | 121 | 128 | 1A,m8 | hsa-miR-30a-5p | UGUAAACAUCCUCGACUGGAAG |
| hsa-miR-30cbrain | UGUAAACAUCCUACACUCUCAGC | ||||
| hsa-miR-30dSZ | UGUAAACAUCCCCGACUGGAAG | ||||
| hsa-miR-30bSZ | UGUAAACAUCCUACACUCAGCU | ||||
| hsa-miR-30e-5p | UGUAAACAUCCUUGACUGGA | ||||
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.