Gene Page: SLC12A8
Summary ?
| GeneID | 84561 |
| Symbol | SLC12A8 |
| Synonyms | CCC9 |
| Description | solute carrier family 12 member 8 |
| Reference | MIM:611316|HGNC:HGNC:15595|Ensembl:ENSG00000221955|HPRD:11563|Vega:OTTHUMG00000159483 |
| Gene type | protein-coding |
| Map location | 3q21.2 |
| Pascal p-value | 0.001 |
| eGene | Anterior cingulate cortex BA24 Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2945116 | 3 | 124840136 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 91572 | gtex_brain_ba24 |
| rs2948805 | 3 | 124841013 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 90695 | gtex_brain_ba24 |
| rs2037236 | 3 | 124841350 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 90358 | gtex_brain_ba24 |
| rs2037235 | 3 | 124841577 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 90131 | gtex_brain_ba24 |
| rs2333043 | 3 | 124842400 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 89308 | gtex_brain_ba24 |
| rs2945120 | 3 | 124842456 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 89252 | gtex_brain_ba24 |
| rs2948806 | 3 | 124842591 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 89117 | gtex_brain_ba24 |
| rs2948807 | 3 | 124842596 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 89112 | gtex_brain_ba24 |
| rs2942811 | 3 | 124842736 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 88972 | gtex_brain_ba24 |
| rs2942812 | 3 | 124842991 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 88717 | gtex_brain_ba24 |
| rs2945119 | 3 | 124843393 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 88315 | gtex_brain_ba24 |
| rs2945118 | 3 | 124843489 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 88219 | gtex_brain_ba24 |
| rs2942813 | 3 | 124843647 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 88061 | gtex_brain_ba24 |
| rs2948796 | 3 | 124843860 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 87848 | gtex_brain_ba24 |
| rs2948795 | 3 | 124843991 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 87717 | gtex_brain_ba24 |
| rs2981515 | 3 | 124844069 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 87639 | gtex_brain_ba24 |
| rs2948794 | 3 | 124844183 | SLC12A8 | ENSG00000221955.6 | 3.149E-7 | 0.01 | 87525 | gtex_brain_ba24 |
| rs2945113 | 3 | 124844757 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 86951 | gtex_brain_ba24 |
| rs2981514 | 3 | 124844922 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 86786 | gtex_brain_ba24 |
| rs2948793 | 3 | 124845139 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 86569 | gtex_brain_ba24 |
| rs1890407 | 3 | 124845944 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 85764 | gtex_brain_ba24 |
| rs2945114 | 3 | 124846408 | SLC12A8 | ENSG00000221955.6 | 2.159E-7 | 0.01 | 85300 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP | 182 | 110 | All SZGR 2.0 genes in this pathway |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP | 157 | 91 | All SZGR 2.0 genes in this pathway |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP | 175 | 108 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS UP | 501 | 327 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | All SZGR 2.0 genes in this pathway |
| PASQUALUCCI LYMPHOMA BY GC STAGE UP | 283 | 177 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 2 DN | 464 | 276 | All SZGR 2.0 genes in this pathway |
| ROETH TERT TARGETS UP | 14 | 11 | All SZGR 2.0 genes in this pathway |
| WANG SMARCE1 TARGETS UP | 280 | 183 | All SZGR 2.0 genes in this pathway |
| BILD MYC ONCOGENIC SIGNATURE | 206 | 117 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS SILENCED BY METHYLATION UP | 461 | 298 | All SZGR 2.0 genes in this pathway |
| RIGGI EWING SARCOMA PROGENITOR DN | 191 | 123 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K9ME3 DN | 120 | 71 | All SZGR 2.0 genes in this pathway |
| BOHN PRIMARY IMMUNODEFICIENCY SYNDROM DN | 40 | 31 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO CSF2RB AND IL4 UP | 338 | 225 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF UP | 418 | 282 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP | 408 | 276 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS LCP WITH H3K4ME3 | 174 | 100 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA MF DN | 41 | 28 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES LCP WITH H3K4ME3 | 142 | 80 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| ROESSLER LIVER CANCER METASTASIS DN | 53 | 29 | All SZGR 2.0 genes in this pathway |